2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxytic acid ethyl ester

2-%284-Hydroxyphenyl%29-4-methylthiazole-5-carboxytic + acid + ethyl + ester is 2- (4-hydroxyphenyl) -4-methylthiazole-5-carboxylic acid ethyl ester. Its chemical structure is described as follows:
The core structure of this compound is a thiazole ring, which is a five-membered heterocyclic ring containing sulfur and nitrogen atoms. A phenyl group is connected at position 2 of the thiazole ring, and there is a hydroxyl group at position 4 of the phenyl group, that is, an OH group. This hydroxyl group endows the compound with certain hydrophilicity and special chemical activity, and can participate in a variety of chemical reactions, such as forming coordination bonds with metal ions or esterification reactions under appropriate conditions.
At position 4 of the thiazole ring, a methyl group is connected, and the methyl group is the electron-supplying group, which will affect the electron cloud distribution of the thiazole ring, thereby changing the chemical properties and reactivity of the whole molecule.
At position 5 of the thiazole ring, a carboxylic acid ethyl ester group, namely -COOCH ² CH, is connected. This ester group structure makes the compound have a certain lipid solubility. In the fields of organic synthesis and drug development, ester groups are often used as modifiable check points to change the physical and chemical properties and biological activities of the compound through hydrolysis or ester exchange reactions with other alcohols.
Overall, the chemical structure of 2 - (4-hydroxyphenyl) -4-methylthiazole-5-carboxylic acid ethyl ester fuses aromatic rings, heterocycles and different functional groups. These structural characteristics jointly determine the unique physical and chemical properties and potential biological activities of the compound. It has important research value and application potential in many fields such as organic synthesis chemistry and medicinal chemistry.

2-%284-Hydroxyphenyl%29-4-methylthiazole-5-carboxytic+acid+ethyl+ester, this is the name of an organic compound, and its Chinese name is 2- (4-hydroxyphenyl) -4-methylthiazole-5-carboxylic acid ethyl ester. Its physical properties are as follows:
- ** Appearance properties **: This compound usually appears as a white to light yellow crystalline powder. Looking at it, it is like a delicate powder with uniform texture and no obvious impurities and uneven color. This appearance feature is a visual manifestation of its physical properties. In laboratory observation or industrial production, it is an important basis for preliminary identification.
- ** Melting point **: Its melting point is in a specific range, generally speaking, about [X] ℃. The melting point is an important physical constant of the compound. By measuring the melting point, the purity of the substance can be preliminarily judged. If the melting point of the sample matches the standard value and the melting range is narrow, it indicates that the purity is high; conversely, if the melting range is wide, it may contain impurities.
- ** Solubility **: In organic solvents, the compound exhibits specific solubility characteristics. For example, in common organic solvents such as ethanol and acetone, it has a certain solubility. It can be slowly dissolved, so that the solution presents a uniform dispersion state, but the solubility in water is poor. This difference in solubility is closely related to the molecular structure of the compound. The hydrophobic groups it contains make it difficult to disperse in water, while the similar miscibility principle of organic solvents makes it soluble in some organic solvents. This property is of great significance in the separation, purification and preparation of compounds.
- ** Stability **: Under conventional storage conditions, the compound has certain stability. However, if exposed to extreme environments such as high temperature, high humidity or strong light, its structure may change. For example, in high temperature environments, chemical bonds within the molecule may be broken or rearranged, resulting in changes in its chemical properties. Therefore, during storage and use, it is necessary to pay attention to the impact of environmental factors on its stability and choose appropriate storage conditions to ensure its quality and performance.

2-% 284 - Hydroxyphenyl% 29 - 4 - methylthiazole - 5 - carboxylic acid ethyl ester is 2 - (4 - hydroxyphenyl) - 4 - methylthiazole - 5 - carboxylic acid ethyl ester. The common synthesis methods are as follows:
First, 4 - hydroxyacetophenone is used as the starting material, and the condensation reaction is carried out with thioacetamide. This step is reacted in a suitable organic solvent, such as ethanol, with the addition of an appropriate amount of basic catalyst, such as potassium carbonate, when heated for a number of refluxes. The carbonyl group of 4-hydroxyacetophenone interacts with the sulfur and nitrogen atoms of thioacetamide to form a thiazole-containing precursor. After the reaction, the preliminary product is obtained by conventional operations such as cooling, filtration, and washing.
Then, the obtained thiazole ring precursor is esterified. It is mixed with anhydrous ethanol, concentrated sulfuric acid is added as a catalyst, and refluxed at a specific temperature. Concentrated sulfuric acid catalyzes the esterification of the carboxyl group in the precursor with the hydroxyl group of ethanol to form the target product 2 - (4-hydroxyphenyl) - 4 - methylthiazole - 5 - ethyl carboxylate. After the reaction is completed, when the system is cooled, the reaction liquid is poured into ice water to neutralize the sulfuric acid, and then the product is extracted with an organic solvent. The solvent is removed by drying with anhydrous sodium sulfate, distillation, and finally purified by column chromatography or recrystallization. Pure 2- (4-hydroxyphenyl) -4-methylthiazole-5-carboxylate ethyl ester can be obtained.
There are also synthetic routes starting from other raw materials. For example, using 4-hydroxybenzoate ethyl ester as the starting material and constructing thiazole ring through multi-step reaction, this route may be more complicated and the reaction conditions are more stringent than the method using 4-hydroxyacetophenone as the raw material. < Br >
The synthesis process must pay attention to the precise control of reaction conditions, such as temperature, time, ratio of reactants and catalyst dosage, which all have a key impact on the reaction yield and product purity. And the separation and purification steps after each step of the reaction should not be underestimated, which is related to the quality of the final product.

2-%284-Hydroxyphenyl%29-4-methylthiazole-5-carboxytic+acid+ethyl+ester ethyl 2- (4-hydroxyphenyl) -4-methylthiazole-5-carboxylate, which is used in medicine, pesticide, material science and other fields.
In the field of medicine, it is a key intermediate for the synthesis of new antibacterial and anti-inflammatory drugs. Modern medical research has shown that many compounds containing thiazole rings have significant biological activities. Using ethyl 2- (4-hydroxyphenyl) -4-methylthiazole-5-carboxylate as the starting material, through a series of chemical modifications and structural optimization, antimicrobial drugs with strong inhibitory effect on specific pathogens can be prepared, providing new ideas for solving the problem of bacterial resistance. In terms of anti-inflammatory, drugs that act on inflammation-related signaling pathways can be developed based on this, providing new ways for the treatment of inflammatory diseases.
In the field of pesticides, it is an important raw material for the synthesis of highly efficient and low-toxicity pesticides. With people's increasing attention to food safety and environmental protection, the development of green pesticides has become a trend. Ethyl 2- (4-hydroxyphenyl) -4-methylthiazole-5-carboxylate has a unique structure. After rational design and synthesis, pesticides with high selectivity to pests and environmental friendliness can be obtained, such as new insecticides that interfere with the growth and development of pests or the nervous system. It can effectively control crop pests and reduce the harm to non-target organisms and the environment.
In the field of materials science, it can be used to prepare functional polymer materials. Because it contains special functional groups, it can polymerize with other monomers, giving the material special properties. For example, smart materials with light, electricity, magnetism, and other responsiveness can be prepared for use in sensors, information storage, and other fields. They can also enhance the thermal stability and mechanical properties of materials, and expand the application of materials in high-end fields such as aerospace and automobile manufacturing.

2-% 284 - Hydroxyphenyl% 29 - 4 - methylthiazole - 5 - carboxytic acid ethyl ester is 2 - (4 - hydroxyphenyl) - 4 - methylthiazole - 5 - carboxylic acid ethyl ester. Many matters need to be paid attention to when storing and transporting this compound.
First of all, store this compound in a cool, dry and well ventilated place. Because it may be quite sensitive to humidity and temperature, high temperature and humid environment can easily cause its properties to change, or cause degradation. Therefore, where it is stored, the temperature should be stable and the humidity should be controlled within a reasonable range. And it should be stored separately from oxidizing agents, acids, alkalis and other substances. Because of its active chemical properties, if it is mixed with the above-mentioned substances, or has a chemical reaction, it will cause safety problems. When storing, it is also necessary to make a label, detailing the name, characteristics, hazard warnings and other information of the compound, so that it can be used and managed.
As for transportation, it is necessary to ensure that the packaging is intact. Packaging materials need to be able to effectively resist vibration, collision and environmental factors. During transportation, temperature and humidity should also be controlled, and appropriate temperature control equipment and moisture-proof measures can be used. And transportation vehicles need to be clean, and no substances that can react with them should be retained. Transportation personnel should know the characteristics of this thing and emergency treatment methods. In case of emergencies, they can respond in time to avoid major disasters. In this way, Fangbao 2 - (4-hydroxyphenyl) - 4-methylthiazole-5-carboxylate ethyl ester is safe and secure during storage and transportation.