2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylic

2-%284-hydroxyphenyl%29-4-methylthiazole-5-carboxylic is 2- (4-hydroxyphenyl) -4-methylthiazole-5-carboxylic acid, which has a wide range of uses. In the field of medicine, it is often the key intermediate for the synthesis of many drugs. Many drugs with antibacterial, anti-inflammatory and anti-tumor activities are used in the research and development and preparation process of 2- (4-hydroxyphenyl) -4-methylthiazole-5-carboxylic acid as the starting material. Through a series of chemical reactions, complex molecular structures with specific pharmacological activities are constructed. This is because of its unique chemical structure, which can impart specific spatial configurations and electronic properties to drug molecules, interact with specific targets in organisms, and achieve precise therapeutic effect.
In the field of materials science, 2- (4-hydroxyphenyl) -4-methylthiazole-5-carboxylic acid can be used to prepare functional materials. Because it contains active groups such as hydroxyl and carboxyl groups, it can chemically react with other organic or inorganic materials to achieve surface modification of materials or build new composite materials. Materials modified by this substance may have better hydrophilicity, biocompatibility or optical properties, and are widely used in biomedical materials, optical materials and other fields.
In the field of organic synthetic chemistry, 2- (4-hydroxyphenyl) -4-methylthiazole-5-carboxylic acid is an important building block for organic synthesis, participating in the synthesis of many complex organic molecules. Organic chemists can use its thiazole ring and benzene ring structure, as well as the reaction activity of carboxyl and hydroxyl groups, to carry out various organic reactions, such as esterification reaction, amidation reaction, nucleophilic substitution reaction, etc., to expand the structural diversity of organic compounds and provide a rich material basis for the development of organic synthetic chemistry.

2-% 284-Hydroxyphenyl% 29-4-methylthiazole-5-carboxylic acid, an organic compound. It has unique chemical properties related to reactivity, stability and interaction with other substances.
When it comes to reactivity, the carboxyl group in this compound is quite active. Carboxyl groups can participate in many reactions, such as esterification with alcohols to form corresponding esters. Under suitable catalytic conditions, the carboxyl group of 2-% 284-hydroxyphenyl% 29-4-methylthiazole-5-carboxylic acid reacts with ethanol to produce 2-% 284-hydroxyphenyl% 29-4-methylthiazole-5-carboxylic acid ethyl ester, which is commonly used in the field of organic synthesis and preparation of ester compounds.
Furthermore, the hydroxyl group also affects its reactivity. Hydroxyl groups can undergo substitution reactions and react with halogenated hydrocarbons to form ether compounds. When the hydroxyl group of 2-% 284-hydroxyphenyl% 29-4-methylthiazole-5-carboxylic acid reacts with bromoethane under basic conditions, corresponding ether products can be formed.
In terms of stability, the thiazole ring imparts certain stability to the compound. The thiazole ring is aromatic and relatively stable in structure. However, in case of strong oxidants or reducing agents, its structure may change. Strong oxidants such as potassium permanganate, under certain conditions, or oxidize certain groups on the thiazole ring, cause changes in the structure and properties of the compound.
From the interaction with other substances, both carboxyl and hydroxyl groups have polarity, and can form hydrogen bonds with molecules with complementary groups. 2-% 284-Hydroxyphenyl% 29-4-methylthiazole-5-carboxylic acid can interact with water molecules by hydrogen bonding, so the compound has certain solubility in water. And because there are hydrophobic parts such as benzene rings in the molecule, its solubility is not infinite.
In addition, the chemical properties of the compound may be affected by environmental factors such as temperature and pH. In different pH solutions, the ionization state of carboxyl or hydroxyl groups changes, which affects their reactivity and solubility. When the temperature increases, the reaction rate is generally accelerated, and various chemical reactions are more likely to occur.

To prepare 2 - (4 - hydroxyphenyl) - 4 - methylthiazole - 5 - carboxylic acid, you can follow the following ancient method.
First take an appropriate amount of 4 - hydroxyacetophenone, place it in a clean kettle, add an appropriate amount of alkali, dissolve it, stir well. For alkali, it can be an aqueous solution of sodium hydroxide or potassium hydroxide, and its concentration needs to be precisely prepared to facilitate subsequent reactions.
Second dose ethyl bromopyruvate, add it slowly, and pay close attention to the temperature in the kettle to prevent excessive temperature fluctuations to prevent side reactions from breeding. The molar ratio of ethyl bromopyruvate to 4-hydroxyacetophenone, when accurately weighed according to a specific formula, is critical to the effectiveness of the reaction.
When the two are mixed, heat up to a specific temperature range, and continue to stir the reaction for several hours. The control of temperature is related to the reaction rate and product purity, so it should not be careless. When the reaction is completed, the material in the kettle should be heated evenly, and the stirring speed should be moderate.
After the reaction is completed, when the material in the kettle is slightly cold, neutralize it with dilute acid and adjust it to a moderate pH value. For dilute acids, such as dilute solutions of hydrochloric acid or sulfuric acid, slowly add them dropwise, and measure their pH value at the same time until the desired range is reached. < Br >
Then extract with organic solvents, commonly used organic solvents, such as ethyl acetate, dichloromethane, etc. During extraction, it is carried out in multiple installments. After each extraction, carefully separate the organic phase.
The obtained organic phase is dried with anhydrous sodium sulfate to remove any remaining water. The amount of anhydrous sodium sulfate depends on the amount of organic phase, and it is sufficient to dry.
After drying, filter out the anhydrous sodium sulfate, and distill the filtrate under reduced pressure to recover the organic solvent to obtain the crude product. During distillation, pay attention to control the pressure and temperature to ensure the effective recovery of the organic solvent.
The crude product is purified by recrystallization. Select a suitable solvent, such as ethanol, water or a mixture of the two, heat to dissolve the crude product, filter while hot to remove insoluble impurities. The filtrate is allowed to stand and cool, until the crystals precipitate, suction filtration, wash the crystals with cold solvent, and dry to obtain pure 2- (4-hydroxyphenyl) -4-methylthiazole-5-carboxylic acid. During the recrystallization process, the choice of solvent, temperature control, and cooling rate all affect the purity and crystal form of the product, so careful operation is required.

I have not heard the price of 2- (4 -hydroxyphenyl) -4 -methylthiazole-5 -carboxylic in the market. However, looking at the "Tiangong Kaiwu", there are many descriptions of the methods and uses of various things, but the price record is rare. This compound is quite special, and it is not an ordinary product in the market, or it is used for pharmaceutical research and chemical testing.
If you want to know its price, it is appropriate to ask for it in the market of various chemical materials and in the field of pharmaceutical research. Or ask chemical merchants, or ask for scientific research equipment. And the price of such things often varies according to the quality, quantity, and supply and demand of the market. If there is a wide range of quality, purity and quantity, and the market is seeking it, the price will be high; if there is a small quantity of quality, and the number of seekers is thin, the price will be low.
And the way of chemical industry, changing with each passing day, new technologies come out frequently, and the price of this product also moves with the changes of the world. Or due to the issuance of new laws, the production increases and the price drops; or due to the increase in demand and the scarcity of sources, the price rises. Therefore, if you want to get the actual price, you should visit the industry in person and inquire about the current situation in detail, so that you can get a definite number, which can be known without speculation.

2-%284-hydroxyphenyl%29-4-methylthiazole-5-carboxylic is an organic compound, and its storage conditions are very critical, which is related to the stability and quality of this compound. According to the "Tiangong Kaiwu" and the experience of the past Fang family, the preservation of such compounds should follow the following general principles.
The first priority is the dryness of the environment. Humid gas can easily cause compounds to be damp, causing reactions such as hydrolysis, which damage their structure and properties. Therefore, it is appropriate to choose a dry place, such as placing a desiccant such as lime in the storage place to absorb moisture and keep the environment dry.
The second is the control of temperature. Excessive temperature can accelerate the reaction of compounds, or cause volatilization and decomposition; too low temperature, or affect their physical state and chemical activity. Usually it is better to be in a cool place, about 5 to 25 degrees Celsius, to avoid large temperature fluctuations.
Furthermore, it is also important to avoid light. Light can trigger photochemical reactions and cause structural changes in compounds. Therefore, it should be stored in an opaque container or hidden in a dark place, which is affected by light.
In addition, sealed storage is also indispensable. In contact with air, compounds are prone to react with oxygen, carbon dioxide and other components. With a sealed bottle and can, air interference can be reduced and its chemical stability can be maintained.
It should also be noted that this compound may be toxic or dangerous, and the place where it is stored should be kept away from fire sources, heat sources and places frequented by humans and animals, and its characteristics and hazards should be clearly marked, so that it can be used and the custodian is aware of its risks. Follow safety procedures. In this way, the purpose of properly storing 2-%284-hydroxyphenyl%29-4-methylthiazole-5-carboxylic can be achieved, so that it still has good quality and performance when required.