2-(4-fluorophenyl)-1,3-benzothiazole

2-% (4-fluorophenyl) -1,3-benzothiazole is one of the organic compounds. Its main application fields are quite wide, and it can be used in many fields such as materials science, medical chemistry, and agricultural chemistry.
In the field of materials science, this compound is often used to prepare functional materials due to its unique structure and photoelectric properties. For example, it can be used as a luminescent material for organic Light Emitting Diodes (OLEDs). For OLEDs, organic compounds are used as luminescent layers, which have the advantages of self-luminescence, wide viewing angle, and fast response speed. Organic compounds such as 2-% (4-fluorophenyl) -1,3-benzothiazole can adjust the molecular structure to optimize the luminous efficiency and color purity of OLEDs, which contributes to the development of display technology.
In the field of medicinal chemistry, such compounds exhibit potential biological activities. Studies have shown that they may have antibacterial, anti-inflammatory, anti-tumor and other pharmacological effects. Due to the special structure of benzothiazole skeleton and fluorophenyl, it can interact with specific targets in organisms and affect the physiological and biochemical processes in organisms, so it is expected to be developed into new drugs. For example, for the specific target of some tumor cells, the rational design and modification of this compound may precisely inhibit the growth and proliferation of tumor cells, providing new ideas for tumor treatment.
In the field of agricultural chemistry, 2-% (4-fluorophenyl) -1,3-benzothiazole can be used as an active ingredient of pesticides. With its inhibitory effect on certain crop pests and pathogens, it can be developed into insecticides, fungicides, etc. Compared with traditional pesticides, pesticides containing this compound with reasonable design may have the advantages of high efficiency, low toxicity and environmental friendliness, which can help the sustainable development of agriculture and ensure the yield and quality of crops.

To prepare 2 - (4 - fluorophenyl) - 1,3 - benzothiazole, you can follow the following ancient method.
First, use 4 - fluorothiophenol and anthranilic acid as starting materials. First take anthranilic acid, put it in an appropriate reactor, add an appropriate amount of dehydrating agent, such as phosphorus pentoxide or phosphorus oxychloride, etc., heat to dehydrate and cyclize to obtain benzothiazole - 2 - carboxylic acid. This step needs to pay attention to the control of temperature. It should be slowly warmed to 180 - 200 ° C, and the reaction should be about 3 - 5 hours. When the reaction solution no longer has obvious bubbles escaping, it is regarded as the reaction is complete. Subsequently, benzothiazole-2-carboxylic acid is mixed with 4-fluorothiophenol, an appropriate amount of acid binding agent, such as potassium carbonate or sodium carbonate, is added to an organic solvent, such as N, N-dimethylformamide or dichloromethane, and the reaction is stirred at 60-80 ° C for 6-8 hours. After the reaction is completed, the reaction solution is washed with a dilute acid solution, the unreacted acid binding agent is removed, and then extracted with an organic solvent. After drying with anhydrous sodium sulfate, the solvent is removed by reduced pressure distillation to obtain the crude product. The crude product is purified by column chromatography or recrystallization to obtain pure 2- (4-fluorophenyl) -1,3-benzothiazole.
Second, use 2-halo-1,3-benzothiazole and 4-fluorophenylboronic acid as raw materials. In the reaction bottle, add 2-halo-1,3-benzothiazole, 4-fluorophenylboronic acid, an appropriate amount of palladium catalyst, such as tetra (triphenylphosphine) palladium, and a base, such as cesium carbonate or potassium phosphate, with an organic solvent, such as toluene or 1,4-dioxane as the reaction medium, pass nitrogen protection, and heat to 80-100 ° C for 8-10 hours. After the reaction, the insoluble matter was filtered off, the filtrate was concentrated, separated and purified by silica gel column chromatography, and 2- (4-fluorophenyl) -1,3-benzothiazole was obtained. These two methods have their own advantages and disadvantages. The former starting material is easy to obtain, but the steps are slightly more complicated; the latter reaction conditions are mild and the yield is high, which can be selected according to actual needs.

2-% 284-fluorophenyl% 29-1% 2C3-benzothiazole, this is an organic compound. Its physical and chemical properties are quite worthy of investigation.
Looking at its physical properties, under normal conditions, it is mostly solid or crystalline powder, due to intermolecular forces and orderly arrangement. Its melting point may have a specific range, because the stability of the molecular structure is related to the lattice energy. The solubility of this compound varies in different solvents. In organic solvents such as ethanol and acetone, it may have a certain solubility, due to the structure of benzene ring and thiazole ring in the molecule, it has a certain lipophilicity; however, the solubility in water may be very small, due to the poor polarity of the whole molecule, the force between water molecules is weak.
In terms of its chemical properties, the benzothiazole ring and the fluorophenyl group endow it with unique reactivity. The nitrogen and sulfur atoms on the benzothiazole ring have solitary pair electrons, which can participate in the coordination reaction and form complexes with metal ions. And this ring system is relatively stable and has certain aromaticity, and can undergo electrophilic substitution reactions, such as halogenation, nitration, sulfonation, etc. The substitution check point or is affected by the electronic and spatial effects of substituents such as fluorophenyl groups. The fluorine atoms in fluorophenyl groups have high electronegativity, which can reduce the electron cloud density of the benzene ring, affecting the activity and selectivity of the electrophilic substitution reaction. At the same time, the compound may participate in the oxidation-reduction reaction. The specific reaction path and conditions depend on the properties of the oxidizing agent or reducing agent in the The physicochemical properties of 2-% 284-fluorophenyl% 29-1% 2C3-benzothiazole are determined by its molecular structure, and may have potential application value in organic synthesis, materials science and other fields.

The prices of various things in the market often change from time to time and vary from situation to situation. This product is no exception for 2- (4-fluorophenyl) -1,3-benzothiazole.
The price of this product in the city is often tied to the state of supply and demand. If the demand for this product is strong and the supply is scarce, the price will be high; if the demand is low and the supply is abundant, the price will become cheaper. And the distance of origin, the difficulty of production, and the quality of quality all have a great impact on its price.
However, I have searched for ancient books all over, but I have not obtained the exact price of this product. Or because of its unusual product, the transaction is not wide, so the price is difficult to determine. Or because each merchant has its own price, there is no fixed rule.
Basically speaking, if in a prosperous city, there are all kinds of conveniences, and there are many seekers, the price may be high; in a remote place, the supply and demand are both small, and the price may be slightly lower. However, it is difficult to determine the range of its price. If you want to know the true price of this thing, you must go to the market in person and consult the merchants before you can get it.
Although I have not been able to specify the range of its price, the market is impermanent, and the price changes at any time. Even if you get it now, it may be different in the future. Only by going through the market and carefully observing the market can you know the price.

2-%284-fluorophenyl%29-1%2C3-benzothiazole, it is one of the organic compounds. In fact, it is necessary to test its safety and toxicity. The safety of this substance is related to many aspects, such as the environment and human contact.
First discuss its impact on the environment. In the natural environment, if this substance is released, its degradation rate and pathway are quite critical. If it is degraded slowly or accumulated in the environment, it may endanger the balance of the ecosystem. If it exists in water bodies, it may affect the survival and reproduction of aquatic organisms, causing disturbance to the food chain.
It is exposed to the human body at times. If it is introduced into the body through breathing, skin contact or accidental ingestion, its metabolism and impact in the body cannot be ignored. However, due to the limitations of current data, it is difficult to determine the specific harm to the human body. However, many organic compounds have latent risks, such as some that can irritate the skin, eyes, or damage the respiratory system.
As for toxicity, experimental data are lacking and it is difficult to determine accurately. However, similar compounds containing benzothiazole structure may have certain toxicity. Or genotoxicity, genetic mutation; or potential carcinogens, long-term exposure to increase the risk of cancer.
The safety and toxicity of Ximing 2-%284-fluorophenyl%29-1%2C3-benzothiazole still need in-depth experimental research. Although it is difficult to determine the details today, according to the general nature of chemical substances, its potential harm should not be ignored, and it should be treated with caution to prevent possible risks.