What is the Chinese name of this compound?
This compound is called artemisinin. Artemisinin is a sesquiterpene lactone compound with a peroxide bridge structure extracted from Artemisia annua. It was first discovered by our country's pharmacist Tu Youyou and her team. It is of great significance in the field of malaria treatment, and can kill malaria parasites efficiently and quickly, saving the lives of countless malaria patients.
Although "Tiangong Kaiwu" was written in the Ming Dynasty, at that time artemisinin had not been discovered and named, but it recorded many drug-related contents, or traces of ancient people's exploration of the medicinal value of Artemisia annua. If it is remembered in classical Chinese form, it can be said:
I have heard that there are many medical techniques and many medicinal stones. Today there is a thing called artemisinin. It is derived from Artemisia annua, which is often grown in the wild, with thin and green leaves. In the past, many physicians used it to observe Artemisia annua, but they did not obtain its delicacy.
In recent times, Tu's Youyou led the crowd, and worked hard to study Artemisia annua. After years of exploration and repeated trials, I finally obtained this artemisinin. Its unique nature, with the structure of an oxygen bridge, is sesquiterpene lactone and the like.
In the treatment of malaria, artemisinin has great merit. The harm of malaria has been around for a long time, and the patients are suffering from cold and heat. In the past, the treatment methods were either ineffective, or there were many drawbacks. Artemisinin can quickly eliminate malaria worms and make the sick cured. The god of its effectiveness is sighed by the world, and saving the people from the suffering of malaria is actually a grand event of medicine, benefiting the common people, and the merit is in the thousands of years.
What is the chemical structure of this compound?
This compound is formed by the symmetry of yin and yang, and the five elements are combined. Its structure is exquisite, as if it were crafted by heaven.
Looking at it, its core structure is like a star vaulting to the moon, with the main element in the center, just like the North Star, surrounded by stars. The surrounding auxiliary elements are arranged in an orderly manner, following the principle of the number of heaven and earth, yin and yang. The atoms are connected by chemical bonds, like threads threading through beads, silk is interlocked, rigorous and agile.
The power of chemical bonds combines strength and softness. Covalent bonds are like the intersection of gentlemen, maintained by shared electron pairs, which are intimate but maintain their independent characteristics; ionic bonds are like the combination of monarchs and ministers, and anions and cations are attracted by electric charges to complement each other and build a stable state.
The distribution of the outer electron cloud also follows the laws of nature. It is like flowing clouds and flowing water, smart and elegant but there are traces to follow. Electrons jump between orbits, like the rise and fall of yin and yang, containing endless opportunities for change.
Its spatial configuration is not a simple list of planes, but a delicate three-dimensional construction. Or it is a regular tetrahedron, which is stable in all directions, showing the beauty of balance; or it is like an octahedron, which is comprehensive in all aspects, showing the beauty of symmetry.
The structure of this compound is seamless, which is in line with the way of yin and yang, and obeys the rules of mathematics. It is a masterpiece of natural creation, providing an exquisite example for the composition of all things in the world.
What is the role of 2,2 ', 2' -nitrotriethanol in this compound?
2%2C2%27%2C2%27%27-%E6%AC%A1%E6%B0%AE%E5%9F%BA%E4%B8%89%E4%B9%99%E9%86%87%EF%BC%88TPP%EF%BC%89%E4%B8%80%E7%B1%BB%E5%8C%96%E5%90%88%E7%89%A9%E4%B8%AD%E7%9A%84%E5%9F%BA%E5%91%BD%E5%90%8D%E7%BB%84%E4%BB%BD%EF%BC%8C%E5%85%B6%E5%9C%A8%E8%AF%A5%E5%8C%96%E5%90%88%E7%89%A9%E4%B8%AD%E8%B5%B7%E7%9D%80%E5%85%B3%E9%94%AE%E7%9A%84%E7%BB%93%E6%9E%84%E5%92%8C%E6%80%A7%E8%B4%A8%E4%BD%9C%E7%94%A8%EF%BC%8C%E5%88%97%E8%AF%B4%E5%A6%82%E4%B8%8B%EF%BC%9A
###1. Structure - Holding the Molecules Together
TPP acts as a crucial structural moiety. The three ethyl groups, along with the secondary amino group, contribute to the overall shape and bulk of the molecule. The secondary amino group can participate in intramolecular hydrogen - bonding interactions. These interactions help in maintaining a specific three-dimensional conformation of the molecule. For example, the ethyl groups' steric hindrance and the potential hydrogen - bonding from the secondary amino group work in tandem to keep the molecule in a form that is suitable for its biological or chemical functions. This well - defined structure is essential for the molecules to interact with other substances in a specific and efficient manner, much like how the unique shape of a key is required to fit into a particular lock.
###2. Reactivity - Participating in Chemical Reactions
The secondary amino group in 2,2 ', 2' - secondary amino triethylamine has lone pairs of electrons. These lone pairs can act as nucleophiles in chemical reactions. For instance, in some organic synthesis reactions, it can attack electrophilic centers. In biological systems, it might be involved in enzyme-catalyzed reactions. The nitrogen atom's ability to donate its lone pair allows the molecule to form new chemical bonds, facilitating reactions such as alkylation or acylation. The presence of the three ethyl groups can also influence the reactivity. They can either enhance or reduce the electron - density around the nitrogen atoms through inductive effects. If the ethyl groups are electron - donating (by + I effect), they can increase the nucleophilicity of the secondary amino group, making it more reactive towards electrophiles.
###3. Solubility and Interaction with Solvents
The combination of the polar secondary amino groups and the non - polar ethyl groups gives 2, 2 ', 2' - secondary amino triethylamine amphiphilic properties to some extent. The polar amino groups can interact with polar solvents like water through hydrogen - bonding, while the non - polar ethyl groups can interact with non - polar solvents or the non - polar regions of other molecules. In a biological context, this property can be significant when the molecule needs to cross cell membranes. The non - polar ethyl groups can help it penetrate the lipid - rich cell membranes, while the polar amino groups can facilitate interactions with polar molecules within the cell or on the cell surface. In industrial applications, this amphiphilic nature can be exploited for solubilizing substances that have both polar and non-polar components, similar to how a surfactant works to make oil and water mix.
What are the main uses of this compound?
This compound has many uses, and the main ones are listed below:
First, it is used in the field of medicine. It can be used as a key ingredient in drugs to help treat many diseases. In the past, doctors used drugs containing this compound to cure people's diseases. Because it can accurately act on human lesions, or regulate physiological functions, or inhibit the growth of bacteria, it is like a good doctor, so that patients can recover.
Second, it also plays an important role in industrial manufacturing. It can be used as an additive for special materials to enhance the properties of materials. For example, when making a tool, adding this material can make the utensil more durable, just like a natural work and clever casting, improve product quality, and meet various industrial needs.
Third, agriculture is also indispensable. It can be made into fertilizers or pesticides to promote crop growth and resist pests and diseases. Farmers use it to make the fields lush and fruitful. It is like a gift from heaven to ensure a bumper agricultural harvest and provide a solid support for the foundation of people's livelihood.
Fourth, in the process of scientific research and exploration, it is an important research object. Scholars use its characteristics to delve into unknown fields and open up the boundaries of science. Or study its reaction mechanism, or explore new application directions, promote scientific and technological progress, such as exploring the mysteries of the sky, and constantly expand the territory of cognition.
What are the physical and chemical properties of this compound?
This compound is a rare wonder in the world, and its physical and chemical properties are very unique.
First of all, its physical properties, looking at its form, under room temperature, it is a crystal clear solid state, just like the flawless jade, with a warm and restrained luster, a delicate and dense texture, and a cool tentacle, as if condensing the cool of heaven and earth. Under the light, the light refraction, as if there is a beautiful and amazing image of flowing brilliance, beautiful and amazing. Its density is moderate, and it feels calm in the hand, but not too heavy, as if it follows a delicate balance. Furthermore, its melting point is quite high, and it needs to be calcined with fire. After a long time, it can be seen slowly melting into a flowing state, just like that tough thing, which can be easily changed by extraordinary power.
As for the chemical properties, this compound is extremely stable, and it is difficult to change it with ordinary acids and bases. Even when placed in strong acids and alkalis, it can be calm and unmoved, as if it is outside the world, and it is alone. However, in case of high temperature and specific catalysts, it will exhibit a wonderful reaction, rearranging the molecular structure and forming a new substance, and this reaction process is precise and orderly, and seems to be guided by laws in the dark. When it met with an active metal, under certain conditions, a displacement reaction could occur, releasing energy. The strength of this energy was beyond imagination, as if it could ignite the mysterious power hidden in the world.