2-(3-Bromo-phenyl)-thiazole-4-carbaldehyde

4-Methylvaleronitrile, its physical properties are as follows:
4-Methylvaleronitrile is a colorless to light yellow liquid at room temperature. It has a certain volatility and can evaporate slowly in the air. The relative density (water = 1) is about 0.8. Compared with water, its density is smaller. If mixed with water, it will float on the water surface.
It is slightly soluble in water and has a low solubility in water. This is because although the nitrile group in its molecular structure has a certain polarity, the longer carbon chain makes the whole molecule more non-polar, resulting in weaker interactions with water molecules with stronger polarity. However, it can be miscible with many organic solvents, such as ethanol, ether, acetone, etc. This is because these organic solvents have similar intermolecular forces to 4-methylvaleronitrile, which is in line with the principle of "similar phase dissolution".
The boiling point of 4-methylvaleronitrile is about 160 ° C - 165 ° C, and the boiling point is relatively high. This is mainly due to the existence of certain interaction forces between molecules, including van der Waals forces and the possible weak hydrogen bonding between nitrile groups, etc., which requires higher energy, that is, higher temperatures, to break free from each other's bondage and become gaseous. Its melting point is about -67 ° C, the melting point is relatively low, and it usually exists in liquid form at room temperature.
In addition, 4-methylvaleronitrile has a special odor, which is irritating and requires attention during use or contact. As an organic compound, it has important applications in organic synthesis and other fields, and understanding its physical properties is crucial for its storage, transportation, and application in related reactions.

To prepare 2 - (3 -benzyl) pyridine-4 -methylquinoline, there are many methods of chemical synthesis, which are described in ancient methods.
First, the nucleophilic substitution reaction can be borrowed. First, the halogenated hydrocarbons containing appropriate substituents meet the pyridine derivatives, and the halogenated atoms are active, which are easy to be attacked by the nucleophilic atoms at specific positions on the pyridine ring, and then bond. This process requires careful selection of reaction conditions, such as temperature and solvent, to make the reaction smooth. And the structure of the halogenated hydrocarbons and the activity of the pyridine derivatives have a great influence on the reaction.
Second, through condensation reaction. Select a compound with a suitable functional group, such as a carbonyl group and an amino group, and under the action of an appropriate catalyst, the two condensate, dehydrate and form a ring, which can cause the formation of the target product. However, the choice of catalyst is crucial, and different catalysts can make the reaction rate, yield and selectivity vary.
Furthermore, the cyclization reaction is used. The appropriate chain compound is used as the starting material to form a ring through the intramolecular reaction. This requires precise control of the reaction conditions to make the chain molecule cyclize in the expected manner to form the desired pyridine-methylquinoline structure.
In addition, metal catalysis is also a good method. Metal catalysts can activate substrate molecules and promote the formation and breaking of chemical bonds. For example, under the catalysis of transition metals, coupling reactions can occur between different functional groups to build complex molecular structures, so as to achieve the synthesis of 2- (3-benzyl) pyridine-4-methylquinoline.
The synthesis of each method has its advantages and disadvantages. It is necessary to weigh the choices according to the actual situation, such as the availability of raw materials, cost, and difficulty of reaction, and carefully adjust the reaction conditions to obtain satisfactory results.

2-%283-%E6%BA%B4%E8%8B%AF%E5%9F%BA%29%E5%99%BB%E5%94%91 are 2- (3-hydroxybenzyl) pyridine and 4-methylquinoline, both of which are organic compounds. They are widely used in medicine, chemical industry and other fields. Their main uses are as follows:
###2- (3-hydroxybenzyl) pyridine
1. ** Pharmaceutical synthesis **: As a key intermediate, it is used to prepare a variety of drugs. Because of its unique chemical structure, it can participate in the construction of many drug molecules. For example, some drugs with antibacterial and anti-inflammatory activities, 2- (3-hydroxybenzyl) pyridine participates in the construction of the drug core skeleton, and other functional groups are introduced through subsequent chemical reactions to give the drug specific biological activity. Taking the research and development of a new type of antimicrobial drug as an example, the compound can be used as a starting material. After multi-step reaction, it is combined with substances containing specific antimicrobial groups to generate drugs that have a good inhibitory effect on drug-resistant bacteria.
2. ** Organic Synthesis **: It acts as an important building block in the field of organic synthesis. Due to the existence of pyridine ring and hydroxybenzyl group, various chemical reactions can occur, such as nucleophilic substitution, redox, etc. In the synthesis of complex organic molecules, its pyridine ring nitrogen atom alkalinity and hydroxybenzyl activity can be used to react with different reagents to construct organic compounds with complex structures and unique functions, providing an important material basis for the development of organic synthesis chemistry.
##4 -methylquinoline < b ** Pharmaceutical field **: Some antimalarial drugs use 4-methylquinoline as the parent structure. Plasmodium develops and propagates in human red blood cells, and 4-methylquinoline drugs can act on specific targets in the metabolic process of Plasmodium and interfere with its normal physiological activities, thereby inhibiting the growth and reproduction of Plasmodium, so as to achieve the purpose of treating malaria. For example, the classic antimalarial drug quinine, although the structure is complex, the 4-methylquinoline structural unit is a key part of its antimalarial activity. In addition, in the development of anticancer drugs, 4-methylquinoline derivatives have shown potential anticancer activity. Studies have found that they can play an anti-cancer role by regulating cancer cell signaling pathways and inducing cancer cell apoptosis.
2. ** Material Science **: 4-methylquinoline can be used to prepare functional materials. In the field of optoelectronic devices, it is introduced into polymer materials to endow the materials with special optical and electrical properties. For example, when preparing organic electroinduced Light Emitting Diode (OLED), the luminescent material containing 4-methylquinoline structure can effectively improve the luminous efficiency and stability of the device. Due to its molecular structure conjugate system and electron cloud distribution characteristics, it is conducive to electron transport and energy conversion, and has broad application prospects in display technology and lighting fields.
3. ** Dye Synthesis **: As an important raw material for synthetic dyes, 4-methylquinoline can be chemically modified to synthesize dyes with bright color and good stability. Its pyridine ring and methyl structure provide a good chromophore and chromophore basis for dye molecules. By changing the type and position of substituents, the color and properties of dyes can be adjusted to meet the needs of different colors and fastness dyes in textile, printing and dyeing industries.

Today, there are di- (tri- hydroxybenzyl) pyridazine, and tetra-methylnaphthalene. What is the market price?
The price of goods in the merchant market often varies according to time, place, quality and supply and demand conditions. For di- (3 - hydroxybenzyl) pyridazine, which is a raw material for fine chemicals or used in the synthesis of medicines and pesticides, its price is related to the difficulty of preparation and the simplicity of the process. If the preparation method is simple, and the raw materials are easily available and abundant, the price may be slightly lower; if the process is complicated and the raw materials are scarce, it needs to be refined and refined, and the price will be high. Tetramethylnaphthalene is also used in the chemical industry, or as an intermediate in organic synthesis, and its price also follows the market rules.
If you want to know the market price of the two, you need to carefully observe the trading market of chemical raw materials, visit merchants, brokers, or consult the platform of chemical trading, and you can get a near-real price. And the market conditions are changing rapidly, and today's price is not tomorrow's price, so you need to explore it in real time. If you just think about it in empty space, it is difficult to determine its exact price. If you want to know its price, you must visit the market in person, study the school carefully, consult the industry, and look at the current situation in order to get its approximate price.

When storing and transporting 2- (3-hydroxybenzyl) pyridine-4-formic acid, it is necessary to be cautious.
Its nature may be sensitive to temperature and humidity, so it should be stored in a cool and dry place, protected from sun exposure and water immersion. The warehouse is convenient and windy, and the temperature is constant. Do not cause sudden changes or cause its quality to change. If the temperature is high, it may not promote its transformation, and if it is wet and heavy, it is easy to cause the risk of deliquescence.
When transporting, people should be cautious and cautious, and use protective equipment, such as gloves and masks, to avoid contact with the body to prevent it from harming the skin and being sucked into the lungs. When loading and unloading, lift and fall lightly, so as not to damage the container or cause the medicine to escape.
During transportation, choose a suitable container for storage and keep it sealed without leakage. When storing with other objects, avoid mixing with strong oxygen agents, acids and alkalis to prevent them from touching and causing drastic changes. Driving should be stable, avoid shocks and emergency brakes, and protect it completely and safely.
In addition, in the storage and transportation equipment, when the logo and warning words of the book are clearly displayed, so that people can know its nature and risk, and can respond quickly in case of situations. Take proper measures to ensure the safety of things and people, and it is safe to avoid any danger.