2-[(2S)-1-[(tert-butoxy)carbonyl]pyrrolidin-2-yl]-1,3-thiazole-4-carboxylic acid

This is the chemical name of an organic compound. If the chemical structure is analyzed according to the ancient classical style of "Tiangong Kaiwu", it should be as follows.
First look at "2 - [ (2S) - 1 - [ (tert - butoxy) carbonyl] pyrrolidin - 2 - yl] - 1,3 - thiazole - 4 - carboxylic acid". "2 -", indicating that the position of a specific atom or group in the main structure is binary. "[ (2S) - 1 - [ (tert - butoxy) carbonyl] pyrrolidin - 2 - yl] ", where the configuration of the" (2S) "chiral center is S type;" 1 - [ (tert - butoxy) carbonyl] pyrrolidin - 2 - yl "," pyrrolidin "is a pyrrolidine ring, connected to the" (tert - butoxy) carbonyl "group at the first position, that is, tert-butoxy carbonyl, and the second position is connected to the main structure. "1,3-thiazole-4-carboxylic acid", "1,3-thiazole" is a thiazole ring, and its 4 positions are connected with "carboxylic acid", that is, carboxylic group, which is the overall main structure.
In summary, this compound has a thiazole ring as the core, a carboxyl group at 4 positions, and a pyrrolidine group with specific chiral and substituent groups at 2 positions. This structure contains heteroatoms such as nitrogen and sulfur, and presents a complex and delicate structure of organic compounds. It may have specific properties and uses in the fields of organic synthesis and medicinal chemistry.

2-%5B%282S%29-1-%5B%28tert-butoxy%29carbonyl%5Dpyrrolidin-2-yl%5D-1%2C3-thiazole-4-carboxylic acid is an organic compound with a wide range of uses. In the field of organic synthesis, this compound is often used as a key intermediate. Due to its unique structure and specific functional groups, it can be combined with many reagents through various chemical reactions to help build more complex organic molecular structures, laying the foundation for the synthesis of new drugs, natural products or functional materials.
In the field of medicinal chemistry, such compounds exist in the structure of nitrogen heterocycles and carboxyl groups, or have potential biological activities. Researchers may explore their interactions with specific targets in organisms by modifying and optimizing their structures, hoping to discover lead compounds with pharmacological activity, and then develop new drugs for the treatment of various diseases. < Br >
In the field of materials science, due to its special chemical structure, or endowing materials with unique properties. For example, introducing it into the structure of polymer materials, or improving the solubility and stability of materials, and even endowing materials with special optical and electrical properties, provides new options for the preparation of high-performance functional materials.
In summary, 2-%5B%282S%29-1-%5B%28tert-butoxy%29carbonyl%5Dpyrrolidin-2-yl%5D-1%2C3-thiazole-4-carboxylic acid has shown important application value and broad development prospects in many fields such as organic synthesis, drug development and materials science.

To prepare 2 - [ (2S) -1 - [ (tert-butoxy) carbonyl] pyrrolidine-2-yl] -1,3-thiazole-4-carboxylic acid, the method is as follows:
Starting material, optional (S) -pyrrolidine-2-carboxylic acid is one. First, (S) -pyrrolidine-2-carboxylic acid is reacted with di-tert-butyl dicarbonate. This step aims to protect the pyrrolidine nitrogen atom with tert-butoxy carbonyl. The reaction conditions should be mild. In a suitable organic solvent, such as dichloromethane, an appropriate amount of organic base, such as triethylamine, is added to help the reaction proceed smoothly. In this way, (S) -1 - (tert-butoxy carbonyl) pyrrolidine-2 -carboxylic acid can be obtained. After
, this product is reacted with a suitable vulcanization reagent, such as Lawesson reagent, to generate the corresponding thioanhydride intermediate. The reaction temperature needs to be precisely controlled, and the solvent can be selected from toluene. This intermediate has high activity and lays the foundation for the subsequent construction of thiazole ring.
At the same time, another key raw material is prepared, such as the reaction of a suitable haloacetyl halogen with thiourea to obtain an intermediate containing active groups, which can be condensed with the above thioanhydride intermediate. The condensation reaction is carried out under base catalysis in a suitable solvent such as N, N-dimethylformamide to promote the formation of thiazole rings, resulting in 2 - [ (2S) -1 - [ (tert-butoxy) carbonyl] pyrrolidine - 2 - yl] - 1,3 - thiazole - 4 - carboxylic acid precursor.
Finally, the precursor is properly treated, such as hydrolyzed under acidic conditions, and the tert-butoxy carbonyl protecting group is removed to obtain the target product 2- [ (2S) -1 - [ (tert-butoxy) carbonyl] pyrrolidine-2-yl] -1,3-thiazole-4-carboxylic acid. Each step of the reaction needs to be carefully monitored to maintain the purity and yield of the product.

2-%5B%282S%29-1-%5B%28tert - butoxy%29carbonyl%5Dpyrrolidin - 2 - yl% 5D - 1,3 - thiazole - 4 - carboxylic acid, this is an organic compound. Its physical and chemical properties are quite critical, and it is related to many properties of this compound.
Describe its physical properties first. Usually, such compounds are mostly solids, but the specific properties may vary depending on the purity and crystallization conditions. Melting point is a key physical parameter, which can help determine the purity and properties of substances. Its melting point may be within a specific range, which needs to be accurately determined by experiments. Under different experimental environments, it may fluctuate slightly. The solubility is also important. In organic solvents such as dichloromethane and chloroform, it may have a certain solubility. Because the molecular structure contains specific functional groups, it interacts with organic solvents and is conducive to dissolution. However, in water, the solubility may be low, because the hydrophobic part of its structure accounts for a large proportion.
Re-discussion of chemical properties. The molecule contains multiple functional groups, each with unique chemical activities. The thiazole ring is aromatic and relatively stable. However, under certain conditions, electrophilic substitution reactions can occur, such as halogenation, nitrification, etc. Due to the uneven distribution of electron cloud density on the ring, the specific position is vulnerable to electrophilic attack. The nitrogen atom on the pyrrolidine ring has a lone pair of electrons, which is alkaline and can react with acids to form salts. The carboxyl group is significantly acidic, and can react with bases to form salts and water, and can also participate in esterification reactions, and form esters with alcohols under the action of catalysts. In addition, tert-butoxycarbonyl (Boc) is a common protective group that can be removed under specific conditions to expose the activity of nitrogen atoms and participate in further reactions. Due to the existence of these functional groups, this compound exhibits various chemical reactivity and has potential application value in the field of organic synthesis.

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