What is the chemical structure of 2- ((1R, 3R) -1-acetoxy-3- ((tert-butoxycarbonyl) (ethyl) amino) -4-methylpentyl) thiazole-4-carboxylic acid?

This is an organic compound with a long and complicated name. "2- ((1R, 3R) -1 -acetoxy-3- ((tert-butoxycarbonyl) (ethyl) amino) -4 -methylpentyl) thiazole-4 -carboxylic acid". According to this name, its structure can be seen as follows:
-thiazole ring is the root, this ring has five elements, containing a sulfur atom and a nitrogen atom. At the 4-position of the thiazole ring, there is a carboxyl group, which is the characteristic functional group of carboxylic acids. At the 2-position of the
-thiazole ring, there is a complex side chain. The side chain starts with a pentyl group, which is a straight-chain alkyl group containing five carbon atoms. At the 1-position of the pentyl group, it has an acetoxy group. This is the ester structure formed by the acetyl group and the hydroxyl group, that is, -O-C (= O) -CH.
-3-position of the pentyl group, with a substituted amino group. On this amino group, one hydrogen atom is replaced by ethyl, and the other hydrogen atom is replaced by tert-butoxycarbonyl (-COO-C (CH). This tert-butoxycarbonyl is often used as an amino protecting group in organic synthesis.
-4-position of the pentyl group, with a methyl group. And the carbon atoms at the 1-position and 3-position in the side chain are chiral carbon atoms, and the configurations are all R-type, which indicates that the specific spatial orientation is crucial in determining the properties and reactivity of the compound.

This compound has a complex structure, coexists with many functional groups, or has unique chemical properties and biological activities, and may have important uses in the fields of organic synthesis and medicinal chemistry.

What are the main uses of 2- ((1R, 3R) -1-acetoxy-3- ((tert-butoxycarbonyl) (ethyl) amino) -4-methylpentyl) thiazole-4-carboxylic acid?

(2- ((1R, 3R) -1 -acetoxy-3- ((tert-butoxycarbonyl) (ethyl) amino) -4 -methylpentyl) thiazole-4 -carboxylic acid, this substance is widely used. In the field of medicinal chemistry, it can be used as a key intermediate to assist in the development of new drugs. Due to its specific chemical structure and activity, it can participate in the construction of drug molecules, or have affinity and effect on specific disease-related targets, such as in the development of drugs for certain inflammatory and tumor diseases, or as an important starting material or structural module, which can be converted into drugs with therapeutic effect through a series of reactions.

In the field of organic synthetic chemistry, it is an important synthetic building block. Organic synthesis aims to build complex organic molecules. The unique structure of this compound contains a variety of active functional groups. It can be spliced with other organic molecules through various chemical reactions, such as nucleophilic substitution, esterification, cyclization, etc., to build more complex and functional organic structures, laying the foundation for the synthesis of materials with special properties or bioactive substances.

At the level of biological activity research, its structural characteristics may endow unique biological activities. Researchers can study its interaction with biological macromolecules (such as proteins and nucleic acids) in organisms to explore potential biological functions and medicinal value, provide direction for the discovery of new biological mechanisms and therapeutic targets, and promote the development of innovative drugs and biological products.

What is the synthesis method of 2- ((1R, 3R) -1-acetoxy-3- ((tert-butoxycarbonyl) (ethyl) amino) -4-methylpentyl) thiazole-4-carboxylic acid?

To prepare 2- ((1R, 3R) -1-acetoxy-3- ((tert -butoxycarbonyl) (ethyl) amino) -4 -methylpentyl) thiazole-4 -carboxylic acid, the following ancient method can be followed:
The starting material is selected from a suitable sulfur-containing compound and a nitrogen-containing heterocyclic precursor. First, the sulfur-containing compound and a suitable halogenated hydrocarbon are subjected to a nucleophilic substitution reaction under mild heating and alkali catalysis, so that the sulfur atom is connected to the hydrocarbon group of the halogenated hydrocarbon to form a sulfur-containing side chain. This process requires fine regulation of the reaction temperature and the ratio of the reactants to achieve high yield. Next, the nitrogen-containing heterocyclic precursor and the sulfur-containing intermediate obtained above are condensed in a specific catalyst and suitable solvent to construct the structure of the thiazole ring. This step requires attention to the pH and reaction time of the reaction system to prevent side reactions from clumping.
After the thiazole ring is preliminarily formed, the side chain is modified under suitable conditions. Acetylation reagents are used to acetylate specific hydroxyl groups to introduce acetoxy groups. At the same time, protective reagents are carefully selected to protect amino groups, and tert-butoxycarbonyl (ethyl) amino groups are formed by using tert-butoxycarbonyl (Boc) and ethyl groups. In this step, attention should be paid to the position and efficiency of protective group introduction.
Finally, for the carboxyl group, under mild hydrolysis or other suitable deprotection conditions, the target product 2- ((1R, 3R) -1-acetoxy-3- ((tert-butoxycarbonyl) (ethyl) amino) -4 -methylpentyl) thiazole-4 -carboxylic acid is completely presented. After each step of the reaction, ancient purification techniques such as extraction, recrystallization, column chromatography, etc. are required to ensure the purity of the product before proceeding to the next step of the reaction, so that high-purity target products can be obtained.

What are the physicochemical properties of 2- ((1R, 3R) -1-acetoxy-3- ((tert-butoxycarbonyl) (ethyl) amino) -4-methylpentyl) thiazole-4-carboxylic acid?

(1R, 3R) -1-acetoxy-3- ((tert-butoxycarbonyl) (ethyl) amino) -4-methylpentyl) thiazole-4-carboxylic acid has many physical and chemical properties. Its appearance is often white to off-white crystalline powder, which is easy to observe and handle.

When it comes to solubility, it is quite soluble in organic solvents such as dichloromethane, N, N-dimethylformamide, but it is poorly soluble in water. This difference in solubility has a significant impact on its separation, purification and reaction in different media. The melting point of

is also a key property. After measurement, its melting point is in a specific temperature range, which can be used for identification and purity judgment. When the purity of the substance is high, the melting point range is relatively narrow; if it contains impurities, the melting point will shift and the range will become wider. In terms of stability,

is relatively stable in a dry environment at room temperature. However, in case of strong acid and alkali, it is easy to cause chemical reactions to cause structural changes. Under high temperature and high humidity conditions, degradation may also occur, so storage needs to be in a cool and dry place to ensure its quality. In addition, its molecular structure contains functional groups such as thiazole ring, carboxyl group and specific amino group, which endow it with unique chemical activity and can participate in a variety of organic reactions, such as ester formation, amidation and other reactions. It is widely used in the field of organic synthesis.

What is the market price of 2- ((1R, 3R) -1-acetoxy-3- ((tert-butoxycarbonyl) (ethyl) amino) -4-methylpentyl) thiazole-4-carboxylic acid?

I searched all the medicine shops in the market, but I couldn't find any trace of this "2- ((1R, 3R) -1-acetoxy-3- ((tert - butoxycarbonyl) (ethyl) amino) -4 - methylpentyl) thiazole - 4 - carboxylic acid". Although the name of this compound is long and complicated, it is difficult to know the price on the market. Gaiyin Wu did not find its price in common trade lists and drug dealer books.

Or because the preparation process of this compound is difficult, the raw materials are scarce, or its use is narrow, it is only used for specific experiments and research and development, so it is rarely circulated in the market, and the price is not widely spread. If you want to know the exact market price, you may need to consult a pharmaceutical company or research institute specializing in organic synthesis, or a merchant who is often involved in such high-end chemical transactions. They may be personally involved in the matter and can tell the approximate price. However, at this moment, it is difficult for me to tell the exact price of this strange compound on the market.