1 3 Thiazole 4 Carboxylic Acid
quinoline thiophene imidazole thiazole

1,3-Thiazole-4-carboxylic acid

Taiy Chemical

Specifications

HS Code

457821

Name 1,3-Thiazole-4-carboxylic acid
Molecular Formula C4H3NO2S
Molecular Weight 129.14 g/mol
Appearance Solid (usually white or off - white powder)
Physical State At Room Temp Solid
Melting Point 179 - 183 °C
Boiling Point Decomposes before boiling
Solubility In Water Slightly soluble
Solubility In Organic Solvents Soluble in some polar organic solvents like DMSO, DMF
Pka Around 3.5 - 4.5 (approximate value for carboxylic acid group)
Odor Odorless (usually)
Stability Stable under normal conditions, but may react with strong oxidizing or reducing agents
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General Information
Frequently Asked Questions
What are the main uses of 1,3-thiazole-4-carboxylic acid?
1,3-butadiene-4-aldehyde acid is an important genus of organic compounds. It has a wide range of uses and plays a key role in the fields of chemical industry, medicine and materials.
In the chemical industry, 1,3-butadiene-4-aldehyde acid is often the key raw material for the synthesis of many complex organic compounds. Due to its unique structure, conjugated double bonds and aldehyde groups, it has active chemical properties and can build complex molecular structures through various chemical reactions. For example, through condensation reaction, it can be combined with other aldehyde and ketone compounds to form compounds with special structures and properties, laying the foundation for the synthesis of fine chemicals.
In the field of medicine, this compound has also emerged. Due to the fact that the functional groups contained in it can interact with specific targets in the body, derivatives based in part on 1,3-butadiene-4-aldehyde acid have been found to have potential biological activity after research, or can be used as lead compounds for the development of new drugs, such as anti-tumor and anti-viral drugs, contributing to human health.
In the field of materials science, 1,3-butadiene-4-aldehyde acid can participate in the synthesis of polymer materials. Through polymerization, it can be introduced into the polymer chain to give the material unique properties. Such as improving the flexibility, heat resistance, chemical corrosion resistance of the material, etc. The resulting materials can be used in packaging, electronics, construction, etc., to improve the comprehensive properties of materials and meet the needs of different fields.
In summary, 1,3-butadiene-4-aldehyde acid, with its unique chemical structure, plays an important role in the chemical industry, medicine, materials and other fields, and promotes the development and progress of related industries.
What are the physical properties of 1,3-thiazole-4-carboxylic acids?
1,3-Butadiene-4-carboxylic acid is an organic compound with unique physical properties. This substance is usually liquid and volatile at room temperature and pressure. Looking at its color, it is almost colorless when it is pure, but if it contains some impurities, it may be slightly yellow.
Its smell is specific, although not pungent and unpleasant, it also has a unique smell, which can be keenly perceived by ordinary people. When it comes to boiling point, due to the force between molecules, the boiling point is in a specific range, which is convenient for separation and purification by distillation in chemical processes. And because its molecular structure contains unsaturated bonds and carboxyl groups, its solubility is unique. In organic solvents such as ethanol and ether, it has good solubility. In organic synthesis, this property is conducive to participating in various chemical reactions and provides convenience for the synthesis of complex organic compounds. In water, because carboxyl groups can form hydrogen bonds with water molecules, there is a certain solubility, but the solubility is not very high. This point needs to be carefully considered during separation and reaction operations.
The density of 1,3-butadiene-4-carboxylic acid is slightly smaller than that of water. If mixed with water, it can be clearly seen floating on the water surface. In addition, the material needs to pay attention to photothermal stability. In light or high temperature environments, unsaturated bonds can easily initiate reactions or cause structural changes of their own, affecting their chemical properties and applications. Therefore, when storing, it should be placed in a cool and dark place to ensure the stability of its physical properties and facilitate subsequent chemical production, scientific research experiments, and other uses.
What are the chemical synthesis methods of 1,3-thiazole-4-carboxylic acid?
The chemical synthesis method of 1% 2C3-pentanedione-4-heptanoenoic acid has many methods, which are described in detail today.
First, ethyl acetoacetate can be initiated by nucleophilic substitution reaction with suitable halogenated olefins. The methylene of ethyl acetoacetate has a certain acidity, and under the action of a strong base, it can form a negative carbon ion. This negative carbon ion attacks the double bond of halogenated olefins nucleophilically to form a substitution product. Subsequently, the target product can be obtained through steps such as hydrolysis and decarboxylation. During hydrolysis, the ester group is converted into a carboxyl group, and under the condition of thermal decarboxylation, the acetoacetic acid structure partially removes a molecule of carbon dioxide, thereby constructing the basic skeleton of the target molecule.
Second, it is also possible to use diethyl malonate as a raw material. Under the action of alkali, diethyl malonate reacts with its methylene carbon anion and halogenated acetone derivatives to form a preliminary addition product. Then, the ester group is hydrolyzed to a carboxyl group, and then decarboxylated by heating to remove one molecule of carbon dioxide. At the same time, the obtained product is introduced into the reaction by appropriate double bonds, such as by means of elimination reaction, to achieve the synthesis of 1% 2C3-glutarone-4-heptanoenoic acid.
Third, the clayson condensation reaction strategy is adopted. Select a suitable ester compound and carry out clayson condensation under strong base catalysis to form a β-ketoate structure. After that, the intermediate product is modified, such as the introduction of alkenyl groups and other functional groups, and then hydrolysis, decarboxylation and other conventional operations to gradually achieve the construction of the target molecule. This process requires precise control of the reaction conditions to ensure the selectivity and yield of each step of the reaction.
All this synthesis method has its own advantages and disadvantages. In practical application, it is necessary to consider the availability of raw materials, the difficulty of controlling the reaction conditions, and the purity requirements of the product.
What is the price range of 1,3-thiazole-4-carboxylic acid in the market?
1% 2C3-pentadiene-4-heptanoenoic acid is available in the market, and its price range varies for various reasons. This compound may be useful in chemical and pharmaceutical fields, and its price often depends on the quality and supply and demand.
If its quality is pure, and the market is prosperous, and the supply is limited, the price may be high. However, the quality is inferior, or the demand is less and the supply is more, the price will be lower. In ordinary markets, the price of 1% 2C3-pentadiene-4-heptanoenoic acid with good quality may range from tens to hundreds of dollars per gram. If you buy it in large quantities, or get the benefit of the price due to the large quantity, the price per gram may be slightly reduced.
Also, the price varies in different places. In prosperous cities, where merchants gather goods, the price may be relatively flat; in remote places, it is not easy to transport goods, and the price may be slightly higher. And with the change of the four times, the change of the industry, the trend of supply and demand also changes, and the price fluctuates accordingly. Therefore, if you want to know the exact price, you should carefully consider the market conditions and consult all merchants, so that you can get a near-real price.
What are the precautions for 1,3-thiazole-4-carboxylic acid during storage and transportation?
1% 2C3-pentadiene-4-heptanoenoic acid is an organic compound. When storing and transporting, be sure to pay attention to the following matters:
First, when storing, place in a cool and ventilated place. Due to its nature or sensitivity to temperature and air, a cool and ventilated environment can effectively avoid chemical reactions caused by excessive temperature, and can also reduce unnecessary reactions with oxygen and other components in the air to ensure its chemical stability.
Second, keep away from fire and heat sources. The compound may be flammable. Once it encounters an open flame or hot topic, it is very likely to cause serious accidents such as combustion or even explosion. Therefore, fireworks must be strictly prohibited in storage and transportation places, and heat sources must be strictly controlled.
Third, it needs to be stored separately from the oxidizing agent. Due to its chemical activity, if it coexists with the oxidizing agent, it is prone to severe chemical reactions such as oxidation, which can cause the material to deteriorate and even cause safety accidents, so it must be strictly stored separately.
Fourth, the storage container must be well sealed. One can prevent it from evaporating and escaping, and the other can avoid contact with outside air, moisture, etc., to prevent hydrolysis and other reactions, and maintain the original properties of the substance.
Fifth, during transportation, it is necessary to ensure that the container does not leak, collapse, fall or damage. Because it has certain chemical hazards, if there is a problem with the container, resulting in material leakage, it will not only cause environmental pollution, but also may pose a serious threat to surrounding personnel and facilities.
Sixth, the transportation vehicle should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. In the event of an accident, fire extinguishing and leakage treatment can be carried out quickly to minimize the loss and harm of the accident.