What is the chemical structure of (S) -10- [ (Dimethylamino) methyl] -4-ethyl-4,9-dihydroxy-1H-pyrano [3 ', 4': 6,7] indolizino [1,2-b] quinoline-3,14 (4H, 12H) -dione monohydrochloride

(S) - 10 - [ (dimethylamino) methyl] - 4 - ethyl - 4,9 - dihydroxy - 1H - pyrano [3 ', 4': 6,7] indolicino [1,2 - b] quinoline - 3,14 (4H, 12H) -dione monohydrochloride, which is a complex organic compound. Its structure is composed of a polycyclic system, the main ring is indolicino [1,2-b] quinoline, on this basis, there is methyl containing dimethylamino at position 10, ethyl at position 4, hydroxyl at position 4 and 9, respectively, and diketone at position 3 and 14, and it forms a salt as a whole and binds to one molecule of hydrochloric acid.

The compound contains nitrogen heterocyclic ring, which is the key structural unit of many bioactive molecules and drugs. The presence of dimethylamino methyl may enhance the water solubility and alkalinity of the compound, which affects its pharmacological activity and pharmacokinetic properties. The substituents such as ethyl, hydroxy, and diketone also significantly change the spatial configuration and electron cloud distribution of molecules, which affect their interaction with biological targets. The monohydrochloride form further affects the stability, solubility and dissociation properties of compounds, which is of great significance in drug development.

What are the physical properties of (S) -10- [ (Dimethylamino) methyl] -4-ethyl-4,9-dihydroxy-1H-pyrano [3 ', 4': 6,7] indolizino [1,2-b] quinoline-3,14 (4H, 12H) -dione monohydrochloride

(S) -10 - [ (dimethylamino) methyl] - 4 - ethyl - 4,9 - dihydroxy - 1H - pyrano [3 ', 4': 6,7] indolo [1,2 - b] quinoline - 3,14 (4H, 12H) -diketone monohydrochloride, this is a delicate organic compound. Its physical properties are quite unique. Looking at its shape, at room temperature, it may be in a white to white crystalline powder, just like the purity of snow and the fineness of the powder.

When it comes to solubility, this substance may have a certain solubility in water, just like a fish entering water, it can be fused with it. This is because the polar groups contained in its molecular structure interact with water molecules, causing them to disperse. In organic solvents, such as methanol, ethanol and other common polar organic solvents, it also exhibits considerable solubility, just like water droplets merging into rivers and can be mixed with them.

As for the melting point, after fine determination, when in a specific temperature range, this temperature range is like a precise door. After crossing this door, the form of matter quietly changes from solid to liquid, showing the wonder of the transformation of the state of matter. In terms of stability, in a normal temperature and dry environment, it is like a sturdy castle that can maintain the stability of its own structure. However, if it encounters a harsh environment such as high temperature, high humidity or strong light, it is like a castle being attacked by wind and rain, its molecular structure may gradually change, and its stability will also be shaken.

In addition, this object may have a specific smell. Although it is not strong and pungent, it is unique. It is like a light and elegant fragrance that lingers, adding a unique charm to it. Its density is also a key physical property. Although it is difficult to measure with intuitive feelings, it affects many properties of matter at the microscopic level, like an invisible bond that connects various mysteries within matter.

What is the use of (S) -10- [ (Dimethylamino) methyl] -4-ethyl-4,9-dihydroxy-1H-pyrano [3 ', 4': 6,7] indolizino [1,2-b] quinoline-3,14 (4H, 12H) -dione monohydrochloride

(S) -10 - [ (dimethylamino) methyl] -4 - ethyl - 4,9 - dihydroxy - 1H - pyrano [3 ', 4': 6,7] indolo [1,2 - b] quinoline - 3,14 (4H, 12H) -diketone monohydrochloride, this medicine is very effective in medical treatment.

It can be used to heal a variety of diseases, and it has also made great achievements in difficult and miscellaneous diseases. In the past, doctors used it as a prescription to treat all kinds of diseases. It can regulate the movement of human qi and blood, and make meridians smooth. In case of stagnation of qi and blood, causing pain all over the body and disharmony of the viscera, this medicine can promote blood circulation and remove blood stasis, make qi and blood return to normal, and the pain will disappear.

For those with weak viscera, this medicine also has the effect of tonifying. It can strengthen the transportation and transformation of the spleen and stomach, nourish the yin of the liver and kidney, and fill the essence of the viscera. It is effective for dizziness and tinnitus caused by deficiency of the liver and kidney, soreness of the waist and knees, and less food and loose stools caused by weakness of the spleen and stomach.

Furthermore, in some diseases caused by heat toxicity, this medicine can clear away heat and detoxify. It can relieve heat toxicity in the body, eliminate carbuncle, swelling and sores, and make the skin rehabilitate and avoid heat toxicity. In fact, it is an indispensable medicine in the hands of physicians, playing a significant role in saving lives, healing and saving people.

What is the synthesis method of (S) -10- [ (Dimethylamino) methyl] -4-ethyl-4,9-dihydroxy-1H-pyrano [3 ', 4': 6,7] indolizino [1,2-b] quinoline-3,14 (4H, 12H) -dione monohydrochloride

The synthesis of (S) -10- [ (dimethylamino) methyl] -4-ethyl-4,9-dihydroxy-1H-pyrano [3 ', 4': 6,7] indoleoxidino [1,2-b] quinoline-3,14 (4H, 12H) -dione monohydrochloride is an important matter for chemical preparation.

To form this compound, it is first necessary to choose a suitable starting material. Or choose indoleoxidine and pyran derivatives with specific functional groups, and the structures of the two must be compatible with the target product. < Br >
The starting material is established, and the reaction step is entered. Or use a condensation reaction to form the core structure of pyrano-indolicidine. In this process, the catalyst is crucial, which can promote the reaction in the desired direction. If a specific organic base or metal catalyst is selected, it depends on the characteristics of the raw material and the reaction mechanism. Temperature and reaction time also need to be precisely controlled. The reaction at different stages has its own appropriate temperature.

Wait for the initial formation of the core structure, and then modify the functional group. To obtain the structure of 4-ethyl and 10- [ (dimethylamino) methyl], use an alkylation reaction. Select appropriate alkylation reagents, such as halogenated alkanes, and adjust according to the reaction conditions and selectivity. The formation of 4,9-dihydroxy and 3,14-diketone, or the reaction of oxidation, hydrolysis, etc., the reagents and reaction conditions used during the process need to be carefully considered in order to obtain high yield and high purity.

As for the salt formation step, to obtain a monohydrochloride salt, add an appropriate amount of hydrochloric acid in an appropriate solvent, adjust the pH value, and make the product salt out. This process requires attention to the type of solvent, the concentration and dosage of hydrochloric acid, so as not to affect the purity and crystal form of the product.

After each step of reaction, the product must be separated and purified. Or by column chromatography, recrystallization and other methods to remove impurities and improve purity, so that the product can reach the required standard. In this way, through various steps, (S) -10- [ (dimethylamino) methyl] -4-ethyl-4,9-dihydroxy-1H-pyrano [3 ', 4': 6,7] indolicidine [1,2-b] quinoline-3,14 (4H, 12H) -diketone monohydrochloride can be formed.

What is the safety of (S) -10- [ (Dimethylamino) methyl] -4-ethyl-4,9-dihydroxy-1H-pyrano [3 ', 4': 6,7] indolizino [1,2-b] quinoline-3,14 (4H, 12H) -dione monohydrochloride

(S) -10 - [ (dimethylamino) methyl] -4 - ethyl - 4,9 - dihydroxy - 1H - pyrano [3 ', 4': 6,7] indolisidino [1,2 - b] quinoline - 3,14 (4H, 12H) -diketone monohydrochloride, this is a rather complex chemical substance.

When it comes to the safety of this substance, it is difficult to make a definite conclusion due to the lack of detailed information. However, based on chemical principles and the characteristics of similar structural substances, it may be speculated as follows. First, it contains a variety of complex functional groups, or has certain chemical reactivity. Like the dihydroxyl structure, or make the substance participate in oxidation, esterification and other reactions under specific conditions, if it is in the body, or interacts with biomolecules, it will affect the physiological process of cells. Furthermore, nitrogen-containing groups such as dimethylamino, whose basic properties may affect the solubility and chemical reactivity of substances, may also interact with acid-base balance in the body and biological macromolecules such as proteins and nucleic acids, interfering with normal physiological functions. The mono-hydrochloride form means that chloride ions and corresponding cations will be dissociated in solution, and a large amount of ion balance in the body will be ingested or changed. From a toxicological point of view, complex organic compounds may be potentially toxic, or cause organ damage, allergic reactions, etc. However, this is only based on the speculation of chemical structure, and the true safety needs to be verified by rigorous experiments, such as cell experiments and animal experiments, to explore its acute toxicity, chronic toxicity, teratogenicity, carcinogenicity, etc., in order to know its safety.