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What are the main uses of S-1-phenyl-1,2,3, 4-tetrahydroisoquinoline
S-1-phenyl-1,2,3,4-tetrahydroisoquinoline is one of the organic compounds. It has a wide range of uses in the field of medicine and is often a key intermediate in drug synthesis. Due to the structure of tetrahydroisoquinoline, it has unique chemical properties and biological activities. It can be chemically modified to derive a variety of compounds with specific pharmacological activities. For example, in the creation of some cardiovascular drugs and nervous system drugs, this compound is often used as a starting material to construct a molecular structure with the required activity through delicate reaction steps.
In the field of materials science, it may also have its own application. Or it can participate in the synthesis of organic materials with specific properties, such as materials with special optical and electrical properties. Due to the phenyl and tetrahydroisoquinoline structures of the compound, it can endow the material with a unique electron cloud distribution and spatial configuration, which in turn affects the overall properties of the material.
In the field of organic synthetic chemistry, it is an important synthetic building block. Chemists can use various chemical reactions to precisely manipulate its structure and realize the construction of complex organic molecules. For example, through carbon-carbon bond formation reactions and functional group conversion reactions, the complexity and diversity of molecules can be expanded, providing rich materials and possible paths for the creation of new organic compounds.
What are the synthesis methods of S-1-phenyl-1,2,3, 4-tetrahydroisoquinoline
To prepare S-1-phenyl-1,2,3,4-tetrahydroisoquinoline, there are two common methods. The first is the Bischler-Napieralski reaction, which is a classic method. First, phenethylamine and acid chloride are used as starting materials to condensate to obtain amides, followed by Lewis acid such as ZnCl ² catalyzed by intramolecular cyclization to obtain 1-phenyl-3,4-dihydroisoquinoline. Subsequently, the double bond is reduced with a suitable reducing agent, such as palladium-carbon hydrogenation, to obtain the target product. In this process, the starting material is easy to obtain, and the reaction conditions are relatively mild, which is commonly used in organic synthesis.
The second is the Pictet-Spengler reaction. With phenethylamine and aldehyde, usually formaldehyde or its equivalents, under acidic conditions, condensation first occurs to form imine ions, and then nucleophilic substitution in the molecule is followed by cyclization to form 1-phenyl-1,2,3,4-tetrahydroisoquinoline. The key to this reaction lies in the control of acidic conditions. The strength and dosage of acid have a great impact on the reaction rate and yield. If the acidity is too strong, or side reactions increase; if the acidity is too weak, the reaction will be slow or even difficult to occur.
These two methods have their own advantages and disadvantages. The Bischler-Napieralski reaction step is slightly more complicated, but the selectivity is good; the Pictet-Spengler reaction step is simple, but the reaction conditions are strict. When synthesizing, it is necessary to choose the method carefully according to the actual situation, such as the cost of raw materials, availability, and purity requirements of the product.
What are the physical properties of S-1-phenyl-1,2,3, 4-tetrahydroisoquinoline
S-1-phenyl-1,2,3,4-tetrahydroisoquinoline is one of the organic compounds. It has specific physical properties and is very important in the field of chemistry.
In terms of its properties, under room temperature, this substance is mostly solid, and its appearance is usually white to off-white crystalline powder, which is delicate and uniform. This is due to the orderly arrangement of its molecular structure, resulting in its appearance.
When it comes to the melting point, it is about [X] ° C. This property is an important basis for the identification of this substance. Due to the specific intermolecular forces and lattice energy, it melts into a liquid state at a specific temperature. The accurate determination of the melting point is very useful in distinguishing its purity and confirming its structure.
Looking at its solubility, this substance exhibits good solubility in organic solvents such as ethanol and chloroform. This is because the molecular structure contains lipophilic groups, which are compatible with the intermolecular forces of organic solvents, so they can be mutually soluble. However, in water, the solubility is very small, and the overall hydrophobicity of its molecules is strong, making it difficult to form effective interactions with water molecules.
In addition, its density is also characteristic, about [X] g/cm ³, this value reflects the compactness of molecular accumulation. Compared with similar compounds, the influence of structural differences on the density can be observed. < Br >
Because its molecular structure contains conjugated systems and nitrogen atoms, it has certain optical and chemical activities, and can play a variety of roles in chemical reactions. It is an important intermediate commonly used in the field of organic synthesis. It has broad application prospects in many fields such as medicinal chemistry and materials science.
What are the chemical properties of S-1-phenyl-1,2,3, 4-tetrahydroisoquinoline
S-1-phenyl-1,2,3,4-tetrahydroisoquinoline is an organic compound with unique chemical properties. This substance contains benzene ring and tetrahydroisoquinoline structures, which endow it with various chemical activities.
From the structural point of view, the benzene ring has a conjugated system, which makes it have certain stability and aromaticity. The electron cloud has a special distribution and can undergo electrophilic substitution reactions, such as halogenation, nitrification, and sulfonation. Under appropriate conditions, halogen atoms, nitro groups, and sulfonic acid groups can replace hydrogen atoms on the benzene ring.
In the tetrahydroisoquinoline structure, nitrogen atoms have lone pairs of electrons, which make them alkaline and can react with acids to form salts. And the structure has a chiral center, and the S configuration determines its optical rotation, which is of great significance in the field of asymmetric synthesis and medicinal chemistry. Due to its chirality, it has stereoselectivity when interacting with other chiral molecules, and has different configurations or different physiological activities in drug development.
In addition, this compound can participate in addition, oxidation, reduction and other reactions due to its carbon-carbon double bond and nitrogen-carbon bond. For example, under the action of a suitable catalyst, the carbon-carbon double bond can be hydrogenated and reduced, changing the degree of molecular unsaturation; nitrogen atoms can be oxidized and converted into different oxidized substances such as nitrogen oxides. S-1-phenyl-1,2,3,4-tetrahydroisoquinoline is rich in chemical properties and has a wide range of uses in organic synthesis, pharmaceutical chemistry and other fields. It can be derived from many compounds with different functions and activities through various chemical reactions.
What is the price of S-1-phenyl-1,2,3, 4-tetrahydroisoquinoline in the market?
I have not heard of the price of S-1-phenyl-1,2,3,4-tetrahydroisoquinoline in the market. This compound may be useful in the field of chemical industry and pharmaceutical research, but its price often varies depending on the purity of the product, the quantity supplied, the situation of demand, the method of preparation and the place of sale.
To know its exact price, it is recommended to consult the merchant of chemical materials, the shop of chemical reagents, or the platform of chemical product trading, professional procurement website. Looking at the changes in the chemical market in recent years, if the price of raw materials rises and the regulations are strict, the price can fluctuate.
Although it is difficult for me to understand its current market price, if you follow this path and visit people in the industry to explore the market, you will definitely be able to obtain a more accurate price to meet your research or use needs.