As a leading (R)-1-(3,4-DIMETHOXY-BENZYL)-6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the use of (R) -1- (3,4-dimethoxybenzyl) -6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride?
(R) -1- (3,4-diethoxyphenyl) -6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline carboxylate has important uses in many fields. In the field of medicinal chemistry, it is often used as a key intermediate to help develop new anti-nervous system diseases drugs. Due to its unique chemical structure, it can interact with neurotransmitter receptors or regulate neural conduction pathways, opening up a new path for drug creation for Parkinson's disease, Alzheimer's disease and other diseases.
In the field of organic synthesis, this compound is an important cornerstone for the construction of complex organic molecules. With its multiple reactive activity check points, chemists can use a variety of organic reactions, such as nucleophilic substitution, redox, etc., to ingeniously modify its structure, synthesize organic materials with specific functions and structures, in the field of optoelectronic materials, or can prepare high-performance luminescent materials, applied to organic Light Emitting Diodes (OLED) and other devices to improve display performance.
Furthermore, in the total synthesis of natural products, (R) -1- (3,4-diethoxyphenyl) -6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline carboxylate can simulate some structural fragments of natural products, providing an effective strategy for the total synthesis of complex natural products, assisting in-depth research on the biological activity and pharmacological mechanism of natural products, and exploring potential medicinal value. All these highlight its indispensable location and wide use in chemistry, medicine and other fields.
What is the synthesis method of (R) -1- (3,4-dimethoxybenzyl) -6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride?
To prepare (R) -1- (3,4-diethoxyphenyl) -6,7-diethoxy-1,2,3,4-tetrahydroisoquinolinic acid ester, the method is as follows:
First take an appropriate amount of 3,4-diethoxyphenethylamine and dissolve it in a suitable organic solvent, such as anhydrous ethanol. Another appropriate amount of 6,7-diethoxy-3,4-dihydroisoquinoline-1 (2H) -one is also placed in the same or soluble solvent system.
Under stirring, slowly mix the above two solutions. The temperature of the reaction system is adjusted to maintain a certain range. This temperature depends on the actual situation of the reaction. It is generally in a state of mild heating, between about 40 and 60 degrees Celsius. At this temperature, the reaction is continuously stirred for a period of time, about several hours, so that the two can fully react.
During the reaction, close attention should be paid to the reaction process, which can be monitored by means of thin layer chromatography. After the reaction reaches the desired level, stop heating and stirring. The reaction mixture is post-treated, such as vacuum distillation to remove the solvent, or extraction with a suitable extractant to separate the organic phase containing the target product.
The obtained organic phase can be further purified by column chromatography, and a suitable eluent can be selected to obtain a high-purity (R) -1- (3,4-diethoxy phenyl) -6,7-diethoxy-1,2,3,4-tetrahydroisoquinolinic acid ester product. During the whole process, the operation needs to be fine, and the conditions of each step should be controlled to ensure the purity and yield of the product.
What are the physical properties of (R) -1- (3,4-dimethoxybenzyl) -6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
(R) -1- (3,4-diethoxyphenyl) -6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline benzoate, which is an organic compound. Its physical properties are related to many aspects.
Looking at its appearance, it may be a crystalline solid, because many similar organic compounds often show this state, with regular lattice arrangement, with specific crystal forms, or needle-like, flake-like, bulk-like, etc., which is very important for identification and separation and purification.
When it comes to melting point, the compound should have a specific melting point range, which is an important indicator for identifying its purity and structure. When heated to a certain temperature, the lattice is destroyed and the solid state is converted to a liquid state. This temperature range is relatively fixed. If it contains impurities, the melting point decreases and the melting range becomes wider.
In terms of boiling point, due to its structure containing a variety of groups, it has a certain molecular weight and intermolecular forces, and it will boil into a gaseous state under a specific pressure. The boiling point is affected by intermolecular forces, such as hydrogen bonds and van der Waals forces.
Solubility is also an important property. Because its molecules contain polar ethoxy groups, benzene rings and other groups, in organic solvents, such as ethanol, chloroform, dichloromethane, etc., or have a certain solubility. Due to the principle of similar phase dissolution, the polar part interacts with the polarity of the organic solvent, and the non-polar benzene ring part also dissolves with the non-polar part of the organic solvent; however, in water, the solubility may be low due to the large proportion of the overall hydrophobic part.
In terms of density, it is related to the type, quantity and closeness of the constituent atoms and the degree of molecular accumulation, which has an impact on its behavior in the solution system, such as stratification and mixing.
In addition, the compound may have a certain refractive index, reflecting its ability to refract light, which is related to the molecular structure and electron cloud distribution, and is of great
What are the chemical properties of (R) -1- (3,4-dimethoxybenzyl) -6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
(R) -1- (3,4 -diethoxy phenyl) -6,7 -diethoxy-1,2,3,4 -tetrahydroisoquinoline carboxylate, this is an organic compound with many unique chemical properties.
Looking at its structure, it contains diethoxy phenyl group and diethoxy group. The presence of ethoxy group significantly affects its physical and chemical properties. Ethoxy group is the power supply group, which can affect the distribution of molecular electron cloud through induction effect and conjugation effect, and then change its reactivity.
In terms of chemical reactivity, the ester group in this compound is quite active. When encountering nucleophilic reagents, such as alcohols, amines, etc., ester groups are prone to nucleophilic substitution reactions to form new esters or amides. This reaction is widely used in the field of organic synthesis and can be used to prepare various functional materials and pharmaceutical intermediates. The tetrahydroisoquinoline structure in the
molecule also has special reactivity. Its nitrogen atom has a lone pair of electrons, which can act as a nucleophilic center and participate in nucleophilic addition or substitution reactions. At the same time, the existence of the tetrahydroisoquinoline ring system endows the molecule with a certain rigidity and spatial structure, which has a profound impact on its interaction with other molecules.
Under the catalyzed conditions of acid or base, the compound may undergo hydrolysis reaction. Under acidic conditions, the ester group is hydrolyzed to form corresponding carboxylic acids and alcohols; under alkaline conditions, the hydrolysis reaction is more rapid to form carboxylic salts and alcohols.
Due to the power supply effect of ethoxy groups, the electron cloud density of the aromatic ring of this compound increases, and it is more prone to aromatic electrophilic substitution reactions, such as halogenation, nitrification, sulfonation, etc. Substituents can be introduced at specific positions in the aromatic ring, expanding a broad space for organic synthesis routes.
In summary, (R) -1- (3,4-diethoxyphenyl) -6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline carboxylate exhibits rich chemical properties due to its special structure, which has important research value and application potential in the fields of organic synthesis and medicinal chemistry.
What is the market price of (R) -1- (3,4-dimethoxybenzyl) -6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride?
Today I have a question, what is the market price of (R) -1- (3,4-diethoxyphenyl) -6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline carboxylate? This is a fine chemical, and its price often varies depending on quality, purity, purchase quantity and market conditions.
If the quality is ordinary and the purity is about industrial grade, the bulk purchase is in the hundreds of grams, or tens of yuan per gram. However, if the purity is as high as scientific research grade, reaching more than 98%, the price per gram may climb to hundreds of yuan.
If the purchase quantity is very large, in kilograms, the unit price per gram may be slightly reduced due to economies of scale. And different seasons and regions, due to changes in supply and demand, the price also fluctuates. < Br >
To obtain an accurate price, it is advisable to consult chemical raw material suppliers, reagent companies, or check on the chemical trading platform to obtain the current exact price.
