quinuclidin-3-yl 1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

Quinarine-3-yl-1-phenyl-3,4-dihydroisoquinoline-2 (1H) -carboxylic acid ester, this is an organic compound. Its main uses involve the field of medical chemistry.
In the creation of medicine, it may be a key intermediate. Due to the unique molecular structure of this compound, it can be spliced and combined with other active groups through a series of chemical reactions. For example, to build a new chemical entity, it can be modified by its structure to adjust the physical and chemical properties and biological activities of the molecule. Like changing its substituents, or affecting the fat-solubility and water-solubility of the compound, it is related to its absorption, distribution, metabolism and excretion in vivo.
In the pharmacological research level of drug development, this compound may have potential biological activity. It can be screened for its activity to explore its effect on specific biological targets. Such as certain disease-related enzymes, receptors, etc., if the compound can bind to the target, or can regulate the relevant physiological and pathological processes, it will pave the way for new drug discovery.
Furthermore, in the field of organic synthesis chemistry, as a characteristic structural unit, it can provide a core framework for the synthesis of complex natural products or drug analogs. Chemists can use their own organic synthesis skills to expand and build a library of compounds with more complex and diverse biological activities based on this compound for further biological activity evaluation and drug development screening.

Alas! Now there is quinuclidin - 3 - yl 1 - phenyl - 3,4 - dihydroisoquinoline - 2 (1H) -carboxylate, which is a side effect on the human body and cannot be ignored.
This medicine may cause gastrointestinal diseases, such as nausea, vomiting, diarrhea. Gastrointestinal people are the officials of the warehouse, and they are responsible for receiving and transporting. The entry of medicine into the body disturbs the gastrointestinal qi, causing abnormal lifting, so nausea and vomiting, diarrhea frequent.
Or cause dizziness and confusion. The brain is the sea of pulp, the meeting of all the yang. If the medicine disturbs its qi and blood and disturbs its gods, it will make you dizzy and dizzy, and your mind will also be dizzy.
Or make the skin rash and itch. Because the medicinal qi is in competition with the human body's qi and blood, the Yingwei is out of harmony, and the evil guest's muscle surface, the skin is itchy and the rash is overgrown.
And it also affects the cardiovascular vessels. Or cause palpitations and palpitations, and the blood vessels are restless. The heart controls the blood vessels, the bias of the medicine, disturbs the heart qi, and causes the blood vessels to run out of their regularity, so there is a palpitations.
Furthermore, between breaths, or feeling impaired. The lung division breathes, moving towards the hundreds of veins. If the medicine hinders its ability to spread and descend, it will be unfavorable for breathing, and the feeling of chest tightness and shortness of breath will occur.
When taking medicine, the advantages and disadvantages should be carefully reviewed, and the changes in its body should be closely observed. If there are various side effects, it should be dealt with quickly to ensure well-being.

This is a compound called quinarine-3-yl-1-phenyl-3,4-dihydroisoquinoline-2 (1H) -carboxylic acid ester. Its chemical properties are quite complex, so let me tell you in detail.
From a structural point of view, the compound contains quinarine, phenyl and parts of dihydroisoquinoline carboxylic acid esters. The quinarine structure gives it a certain alkalinity because the nitrogen atom has lone pairs of electrons and can bind protons. This alkalinity may neutralize with acids in chemical reactions to form corresponding salts.
Phenyl is an aromatic hydrocarbon group, rich in electron clouds, with high stability and conjugation effect. This conjugate system can affect the electron distribution and reactivity of compounds. For example, in electrophilic substitution reactions, phenyl groups easily attract electrophilic agents to attack, exhibiting unique reaction characteristics.
3,4-dihydroisoquinoline-2 (1H) -carboxylic acid ester moiety, the presence of ester groups makes the compound possible to hydrolyze. Under acidic or basic conditions, ester bonds can undergo hydrolysis. In acidic media, hydrolysis is to carboxylic acids and alcohols; in alkaline media, hydrolysis is more rapid, resulting in carboxylic salts and alcohols.
In addition, the compound may have a certain lipid solubility due to the inclusion of multiple hydrophobic hydrocarbon structural parts. This lipid solubility may affect its solubility in different solvents, or have good solubility in organic solvents, but poor solubility in water.
From a stereochemical point of view, the 3-position of quinoline is connected to isoquinoline carboxylate, or there is a stereoisomerism phenomenon, and different stereoconfigurations may have significant effects on its physical and chemical properties.
Overall, the chemical properties of this compound are determined by the synergy of its various parts, and the diverse structures endow it with rich chemical reactivity and unique physical properties.

The method of preparing quinuclidin - 3 - yl 1 - phenyl - 3,4 - dihydroisoquinoline - 2 (1H) -carboxylate has been around for a long time.
First, it can be prepared from a specific starting material through a multi-step reaction. First take 1 - phenyl - 3,4 - dihydroisoquinoline - 2 (1H) -carboxylic acid, react with appropriate reagents under suitable conditions to activate its carboxylic group. Reagents such as thionyl chloride can be used to react with it to form the corresponding acid chloride. This acid chloride is highly active, and then meets quinuclidin-3-ol. In the presence of suitable bases, such as triethylamine, in organic solvents, such as dichloromethane, nucleophilic substitution reactions occur to obtain the target product. During this process, attention should be paid to the reaction temperature, time and reagent dosage. The temperature should not be too high to avoid side reactions. The time also needs to be precisely controlled to ensure that the reaction is complete.
Second, another route can also be used. First modify quinuclidin-3-ol to make it more nucleophilic. It can be reacted with appropriate protecting groups to protect specific groups from unnecessary changes in subsequent reactions. Subsequently, the modified quinuclidin-3-ol is reacted with an active derivative of 1-phenyl-3,4-dihydroisoquinoline-2 (1H) -carboxylic acid. This active derivative can be obtained by appropriately treating the acid, such as converting it into an active ester. The two react in a suitable solvent under the action of a suitable catalyst, and finally remove the protecting group to obtain the target compound. This path requires careful selection of protecting groups and deprotection conditions to ensure that the protection and deprotection steps proceed smoothly without affecting the structure and purity of the target product.
Furthermore, one-pot preparation can also be attempted. The relevant raw materials and reagents are added to the reaction system in a certain order. Under the carefully designed reaction conditions, the reaction proceeds continuously to directly obtain quinuclidin-3-yl 1-phenyl-3,4-dihydroisoquinoline-2 (1H) -carboxylate. Although this method can simplify the operation steps, the control requirements of the reaction conditions are more stringent, and a deep understanding of the mechanism and mutual influence of each step of the reaction is required to achieve efficient preparation.

I haven't heard of "quinuclidin - 3 - yl 1 - phenyl - 3,4 - dihydroisoquinoline - 2 (1H) - carboxylate" at the market price. This is a very professional chemical substance, and its price often varies depending on purity, source, supply and demand.
If you want to find its price, you should follow various paths. First, you can visit the website of the chemical reagent supplier to view its product catalog and pricing. Many suppliers may have this product, but the price is different from the merchant or different, so you need to compare it in detail. Second, you can communicate with people in the chemical industry, such as chemical engineers, scientific researchers, who often come into contact with such materials due to their work, and know the approximate price range. Third, if you work in an academic institution or enterprise, you can consult the purchasing department, who often communicate with suppliers to get accurate quotations.
However, due to the special use of this substance, it is only used in specific laboratories or industrial production. Its market circulation may be limited, and it is difficult to generalize the price. And its preparation or complex process involves the cost of raw materials and production scale also affect its price. Therefore, in order to determine the price, it is necessary to consult the relevant suppliers or professionals in detail according to the specific purchase quantity, purity requirements and other factors to obtain the exact price range.