Quinoline-4-boronicacid,97%

Quinoline-4-boronic acid, 97%, has a wide range of common uses. In the field of organic synthesis, it is often used as a key intermediate. Taking the arylation reaction as an example, it can form carbon-carbon bonds with halogenated aromatics under palladium catalysis and other conditions through Suzuki-Miyaura coupling reaction, thereby preparing many complex organic molecules with biological activity and photoelectric properties. This reaction condition is relatively mild and has good selectivity. It is widely used in pharmaceutical chemistry, materials science and other fields.
In the process of drug research and development, because the quinoline structure is widely present in various bioactive molecules, quinoline-4-boronic acid can be chemically modified to introduce specific functional groups to synthesize compounds with potential pharmacological activities for screening new drugs.
In the field of materials science, through the coupling reaction it participates in, conjugated polymers can be synthesized for use in photovoltaic materials such as organic Light Emitting Diode (OLED) and organic solar cells to regulate the electronic structure and optical properties of materials. Due to the characteristics of boron-containing functional groups, it is also promising in the construction of chemical sensors, which can selectively interact with specific analytes and realize the detection of targets through signal changes.

The synthesis of quinoline-4-boronic acid (97%) is of great interest in the field of chemical synthesis. Common synthesis routes include quinoline as the starting material, through halogenation, the 4-position of quinoline is introduced into halogen atoms. This halogenation process, or the use of halogenated reagents such as bromine and iodine, under suitable reaction conditions, such as specific temperatures and solvent environments, prompts the halogen atoms to precisely replace the 4-position.
Then, the halogenated quinoline product is reacted with metal-organic reagents, such as organolithium reagents or Grignard reagents, to generate the corresponding organometallic intermediates. This intermediate has high activity and can be nucleophilic substitution with borate esters, such as trimethoxy borate ester or pinacol borate. During the reaction, the carbon-metal bond of the metal-organic intermediate undergoes nucleophilic attack on the boron atom of the borate ester, forming a new carbon-boron bond, and then forming quinoline-4-boronic acid.
Another synthesis idea is to use aromatic hydrocarbons containing specific substituents as raw materials to construct a quinoline skeleton through multi-step cyclization, and at the same time introduce boric acid groups during or after cyclization. This method requires fine regulation of reaction conditions to ensure the regioselectivity of the cyclization reaction and the accuracy of the introduction of boric acid groups. The solvent, temperature, catalyst and other factors involved in the reaction have a significant impact on the yield and purity of the synthesis. After synthesis, it still needs to go through separation and purification steps to obtain high-purity quinoline-4-boronic acid products. Commonly used purification methods include column chromatography, recrystallization, etc., which are reasonably selected according to the characteristics of the products and the properties of impurities.

Quinoline-4-boronic acid, with a content of 97%, has many physical properties. Its shape is usually white to light yellow crystalline powder, which is easy to observe and distinguish.
The melting point is about 275-280 ° C. The melting point is the inherent characteristic of the substance. Under specific conditions, the substance changes from solid to liquid state. This temperature range is of great significance for its identification and purification.
In terms of solubility, it is slightly soluble in water. Water is a common solvent. This property indicates that it has limited solubility in water, but it can be slightly soluble in polar organic solvents such as methanol and ethanol. In the selection of solvents for organic synthesis, this solubility characteristic helps chemists find suitable solvents to facilitate the reaction.
Furthermore, the relative density of the substance has a certain value. Although the exact value often varies slightly according to the experimental conditions, it is still an important characterization of its physical properties and is indispensable when considering the relationship between mass and volume.
Its stability also needs attention, and it is relatively stable at room temperature and pressure. However, when encountering strong oxidizing agents, strong acids or strong bases, it is easy to cause chemical reactions to cause structural and property changes. Therefore, when storing and using, it is necessary to avoid such substances, and choose suitable environmental conditions to ensure their quality and performance.

Quinoline-4-boronic acid, content 97%, this substance should be stored in a dry, cool and well-ventilated place. Because of its certain chemical activity, it is quite sensitive to environmental conditions. Store away from fire and heat sources to prevent temperature rise from changing its chemical properties or causing danger.
This product should be stored separately from oxidants, acids, alkalis, etc., and must not be mixed. Chemical reactions may occur due to contact with it, which may damage its quality, or even lead to safety accidents. Warehouses should be equipped with suitable materials to contain leaks to prevent accidental leaks and deal with them in time to avoid environmental pollution caused by their diffusion.
Storage containers must be well sealed to avoid long-term contact with air. Due to water vapor, oxygen and other components in the air or react with them, the purity and quality are affected. The container must be sealed as soon as possible after taking it to maintain its chemical stability.
During handling, it should be handled lightly to prevent damage to the packaging and container. If the packaging is damaged and the substance is exposed, it may not only affect its own quality, but also pose a threat to the surrounding environment and personal safety.
In short, proper storage of quinoline-4-boronic acid is essential to ensure its quality, ensure safe use and avoid environmental pollution. It must be strictly carried out in accordance with the above conditions.

Quinoline-4-boronic acid, 97% of the market price, varies with time, and also varies with the width of the market and the amount of goods. Looking back at the past, this product was used in the chemical industry, and the number of people used it, and its price was related to many parties.
If the market is prosperous in demand, but the supply is small, the price will tend to increase. However, if there are many producers, the market is full of goods, and the demand is scarce, the price should drop. Recalling the chemical industry in the past, the price of similar products varies greatly due to different supply and demand.
The price of this product may vary due to the difficulty of the production method and the high cost. If the system is difficult, the materials required are wide, and the labor cost is huge, the price will be high; if the system is easy, the materials are saved and the labor is simple, and the cost is light and the profit is thick, the price will be appropriate.
Furthermore, the distance of the city and the difficulty of transportation are also variables of the price. If the distant city is expensive, the price will increase; if the nearby city is transported, the price will decrease.
To sum up, if you want to know the current market price of quinoline-4-boronic acid, 97%, when you carefully observe the supply and demand, the cost of production, and the distance of transportation, etc., you can understand the approximation, and it cannot be generalized.