Quinoline-2,3-dicarboxylic acid dimethylester

Quinoline-2,3-dicarboxylic acid dimethyl ester, its chemical structure is a compound containing a quinoline ring. The quinoline ring is a benzopyridine structure with a nitrogen heteroatom. At the 2nd and 3rd positions of the quinoline ring, each is connected to a carboxylic acid dimethyl ester group.
The carboxylic acid dimethyl ester group is formed by esterification of the carboxylic group and methanol. In this structure, the quinoline ring endows the compound with aromatic properties and certain stability and electronic properties. The carboxylic acid dimethyl ester group connected to the 2nd and 3rd positions introduces polar functional groups, which affects its physical and chemical properties.
In this structure, the conjugated system of the quinoline ring presents a specific pattern of electron cloud distribution, which affects its spectral properties and reactivity. Among dimethyl carboxylate groups, the carbonyl group has certain electrophilicity and can participate in a variety of organic reactions, such as nucleophilic addition. The alkoxy part of the ester group also contributes to the solubility and spatial structure of the molecule. The overall structure of this compound makes it potentially useful in organic synthesis, pharmaceutical chemistry and other fields, and can be used as an intermediate to construct more complex compound structures.

Quinoline-2,3-dimethyl dicarboxylate has a wide range of uses. In the field of medicine, it is a key raw material of traditional Chinese medicine. It can be converted into compounds with unique biological activities through a specific reaction process, which can be used to create new drugs, or anti-cancer drugs, or anti-inflammatory products, helping humans fight various diseases and improve health and well-being.
In the field of materials science, it also shows extraordinary potential. After ingenious chemical modification and processing, materials with specific optical and electrical properties can be prepared. For example, it can be used to synthesize luminescent materials, applied to display technology to make the light color of the screen more colorful and enhance the visual experience; or it can be used to prepare conductive materials to promote the development of electronic devices in a more efficient and lightweight direction.
In the field of organic synthesis, quinoline-2,3-dimethyl dicarboxylate is like a cornerstone. Many complex and high-value organic compounds are derived from it through carefully designed chemical reaction paths. It provides organic synthetic chemists with rich imagination and creative possibilities, driving the continuous development of organic synthetic chemistry, generating countless novel synthesis strategies and methods, helping to construct more complex and delicate organic molecular structures, and laying the foundation for technological innovation in many fields.

The synthesis method of quinoline-2,3-dicarboxylic acid dimethyl ester has been known for a long time, and now it is the way for you.
First, quinoline is used as the starting material, and it can be obtained by oxidation and esterification in two steps. First, quinoline is oxidized with a strong oxidant, such as potassium permanganate or potassium dichromate, at a suitable temperature and pH, to oxidize the 2,3 positions of quinoline to obtain quinoline-2,3-dicarboxylic acid. This step requires careful regulation of the reaction conditions. Due to the strong oxidative properties of the oxidant, a little carelessness can easily lead to excessive oxidation and damage to the product. Then, the obtained quinoline-2,3-dicarboxylic acid is mixed with methanol, concentrated sulfuric acid or p-toluenesulfonic acid is used as a catalyst, and the esterification reaction is carried out by heating and refluxing. After separation and purification, quinoline-2,3-dicarboxylic acid dimethyl ester can be obtained.
Second, an anthranilic acid derivative is used as the starting material. First, the anthranilic acid derivative is reacted with a suitable halogenated hydrocarbon to construct a quinoline ring system. Then, a carboxyl group is introduced into the ring, which can be reacted with carbon dioxide by the format reagent or other carboxylation means. Finally, the esterification reaction is carried out, and the carboxyl group is converted into a methyl ester group by the action of methanol and catalyst, thereby obtaining the quinoline-2,3-dicarboxylic acid dimethyl ester. This path requires a precise grasp of the sequence of reaction steps and the reaction conditions of each step in order to obtain the ideal yield and purity.
Third, the cross-coupling reaction strategy catalyzed by palladium is adopted. Quinoline derivatives containing halogen atoms and boric acid or borate derivatives containing carboxyl groups are used as raw materials, and in the presence of palladium catalysts, ligands and bases, the coupling reaction is carried out to obtain quinoline compounds containing carboxyl groups. Subsequently, esterification with methanol is used to prepare the target product. Although this method requires specific palladium catalysts and ligands, it has good selectivity and can effectively construct complex molecular structures, providing a novel and efficient way for the synthesis of quinoline-2,3-dicarboxylic acid dimethyl ester.

Quinoline-2,3-dicarboxylic acid dimethyl ester, this is an organic compound with unique physical properties. Its properties are usually white to light yellow crystalline powder, which is delicate in appearance, like frost and snow.
From the melting point, it is about 132-136 ° C. This temperature is like a boundary. When it reaches this limit, the substance gradually melts from the solid state to the liquid state, just like ice and snow melt into the warm sun. Its solubility in organic solvents is quite considerable, such as common chloroform and dichloromethane, which can be quietly integrated, just like fish entering water, invisible. However, in water, its solubility is very small, just like oil floating in water, distinct.
Furthermore, this compound has a certain stability. Under normal temperature and pressure, it is not easy to react with the surrounding substances easily, just like a hermit who is alone and does not disturb the world. In case of strong acids and alkalis, its stability will be destroyed, just like a weak body that cannot withstand wind and rain, and a corresponding chemical reaction will occur to produce other products.
Its density is slightly larger than that of water, and when placed in water, it will slowly sink, just like a stone entering the water and returning to the bottom. And its smell is slight, if not carefully sniffed, it is difficult to detect, like a fragrance hidden in a corner, which needs to be perceived by a caring person.
To sum up, dimethyl quinoline-2,3-dicarboxylate has unique physical properties and has important uses in organic synthesis and other fields, adding a touch of brilliance to the delicacy of chemistry.

The price range of dimethyl quinoline-2,3-dicarboxylate in the market is difficult to determine. The price of this product often changes due to various reasons, such as the state of supply and demand, the difference in manufacturing technology, the ups and downs of market conditions, and the distance of production sources.
In the past, the situation of supply and demand has a great impact on the price. If there are many people who want it, and the amount of supply is small, the price will often increase; on the contrary, if the supply exceeds the demand, the price may drop. And the difference in manufacturing technology is also related to the price. Good manufacturing technology may reduce its cost and make the price different.
As for the ups and downs of market conditions, it is also the key. The market is prosperous, all kinds of industries are prosperous, and there are many things needed, and the price may go up; if the market is sluggish, the price may go down. And the source of production is far and near, which is related to freight and other costs, and can also make the price different. In places near production, the freight is saved, and the price may be slightly lower; in remote production, the price may be slightly higher because of the freight.
Now if you want to know the exact price of quinoline-2,3-dicarboxylic acid dimethyl ester, you should carefully consider the situation of the city and consult various merchants to obtain a near-real price. However, roughly speaking, its price may fluctuate within a certain range due to the above reasons, and it is difficult to conceal its exact value.