methyl7-chloro-4-hydroxyquinoline-2-carboxylate

Methyl-7-chloro-4-hydroxyquinoline-2-carboxylic acid ester, this is an organic compound. It has a wide range of uses and is often used as an intermediate in drug synthesis in the field of medicine. Geinoquinoline compounds have various biological activities, such as antibacterial, anti-inflammatory, and anti-tumor. The specific structure of this compound may give it unique pharmacological properties. Through chemical modification and transformation, more complex drug molecules can be constructed to deal with various diseases.
In the field of pesticides, it also shows important value. Quinoline derivatives may have insecticidal and bactericidal activities. Methyl-7-chloro-4-hydroxyquinoline-2-carboxylic acid esters have been rationally designed and modified, or developed into new pesticides to help control agricultural diseases and insect pests and ensure crop yield and quality.
Furthermore, in the field of organic synthesis chemistry, as a key intermediate, it can participate in many chemical reactions to construct complex organic molecules. Chemists can achieve the synthesis of novel organic compounds by regulating and transforming their functional groups, providing an important cornerstone for the fields of materials science and total synthesis of natural products.

The method of synthesizing methyl 7-chloro-4-hydroxyquinoline-2-carboxylic acid esters has been studied by chemists throughout the ages, and it is now a common method in the world.
One is a classic chemical synthesis path. Using a suitable aromatic amine compound as the starting material and a specific halogenated carboxylic acid ester under appropriate reaction conditions, the condensation reaction is carried out to form a key intermediate. This intermediate is then cyclized to form a quinoline ring system. During this period, the temperature, pH and reaction time of the reaction need to be precisely regulated to make the reaction proceed smoothly towards the target product. For example, in an inert gas-protected environment, a specific organic solvent is used as the reaction medium, and a strong acid or strong base is used to catalyze the reaction to occur efficiently. After the formation of the quinoline ring, chlorine atoms are introduced at a suitable position through halogenation reaction, and finally the target product is obtained by hydroxylation. Methyl 7-chloro-4-hydroxyquinoline-2-carboxylic acid ester.
Second, the synthesis strategy can be catalyzed by transition metals. Using transition metals such as palladium and copper as catalysts with specific ligands can effectively promote the coupling reaction between various substrates. In this synthesis, the substrate containing quinoline skeleton and halogenated methyl carboxylate are first coupled under the catalysis of transition metals to construct the basic molecular structure. Subsequently, the metal-catalyzed halogenation and hydroxylation reactions are used to introduce chlorine atoms and hydroxyl groups in sequence to precisely synthesize the target product. The advantage of this method is that the reaction conditions are relatively mild and highly selective, which can reduce the occurrence of side reactions and improve the purity and yield of the product.
Another idea of biosynthesis can be used for reference. Some microorganisms or enzymes have the ability to catalyze specific chemical reactions. Microorganisms that can catalyze the synthesis of quinoline-like structures can be screened out, or specific enzymes can be used to simulate the metabolic pathways in organisms, and simple starting materials can be gradually converted into target products. This biosynthetic method is green and environmentally friendly, and the reaction conditions are mild, but the current technology may have challenges such as limited substrate range and slow reaction speed, which need to be further optimized and explored.

Methyl-7-chloro-4-hydroxyquinoline-2-carboxylic acid ester is a kind of organic compound. According to its physical properties, it is often in a solid state at room temperature and pressure, but its specific form may also be affected by impurities and preparation methods. Its color is mostly white to light yellow powder, which is due to the existence of conjugated systems and chlorine atoms in the molecular structure.
When it comes to melting point, the exact value is subject to test conditions, and the approximate range is about 150-180 ° C. This melting point range is derived from the comprehensive results of intermolecular forces, such as hydrogen bonds, van der Waals forces, etc. The compound has poor solubility in most organic solvents and is only slightly soluble in polar organic solvents such as ethanol and acetone. Due to the coexistence of polar groups and non-polar quinoline rings in the molecular structure, its affinity in organic solvents is limited. In water, it is extremely difficult to dissolve because its polarity is not enough to overcome the force between water molecules.
Its density is about 1.4-1.6 g/cm ³ according to theoretical calculations and some experimental measurements. This density is closely related to the molecular structure. The compact structure of the quinoline ring and the relative mass of the chlorine atom contribute more. In addition, the compound is stable and can be stored for a long time in a dry environment at room temperature. However, in case of strong acid and alkali, the ester group, hydroxyl group and other functional groups in the molecular structure are vulnerable to attack, resulting in hydrolysis, substitution and other reactions.

Methyl-7-chloro-4-hydroxyquinoline-2-carboxylic acid ester is one of the organic compounds. Its chemical properties are considerable and have unique reaction characteristics.
In terms of acidity, the hydroxyl group in the molecule can release protons, showing a certain acidity. In the presence of suitable bases, the hydrogen of the hydroxyl group can be replaced to form corresponding salts. This property can be used to form new chemical bonds in organic synthesis, laying the foundation for the preparation of more complex compounds.
Its ester group also has active chemical activity. Under hydrolysis conditions, ester groups can undergo hydrolysis reactions. In acidic media, the corresponding carboxylic acids and alcohols are hydrolyzed; in alkaline media, carboxylic salts and alcohols are formed. This hydrolysis reaction is of great significance in organic synthesis and biological metabolism, providing the possibility to regulate the structure and function of compounds.
Furthermore, its quinoline ring structure endows the molecule with aromatic and conjugated systems. This conjugated system affects the electron cloud distribution of the molecule, making the molecule unique in physical properties such as light and electricity. At the same time, the conjugated structure also enhances the stability of the molecule. In specific chemical reactions, it can be used as a stable reaction check point to participate in various electrophilic and nucleophilic substitution reactions, and expand the chemical transformation path of compounds. < Br >
As a substituent, chlorine atoms can affect the electron cloud density of molecules due to their electronegativity, which in turn affects the reactivity and selectivity of molecules. In nucleophilic substitution reactions, chlorine atoms can be used as leaving groups and replaced by other nucleophiles, thereby introducing new functional groups and enriching the structural diversity of compounds.

I look at this "methyl 7 - chloro - 4 - hydroxyquinoline - 2 - carboxylate", which is a chemical substance, the Chinese name may be methyl 7 - chloro - 4 - hydroxyquinoline - 2 - carboxylate. However, its market price range is difficult to specify.
Because of the unpredictable market conditions, the price of this substance is subject to multiple factors. First, the preparation process is complicated and different. If the preparation requires complex processes, expensive raw materials and special equipment, the cost will be high and the price will be high; conversely, if the process is simple, the price may be relatively low. Second, the supply and demand relationship has a great impact. If the market demand is strong and the supply is limited, the merchant will raise the price; if the demand is low and the supply is sufficient, the price will tend to decline. Third, the quality difference is also the key. High purity, high quality, the price is often higher than ordinary quality.
Also look at "Tiangong Kaiwu". Although it is an ancient scientific and technological masterpiece, the chemical substance trading market at that time was very different from today, and it is difficult to find traces of the price of such modern fine chemicals in the book. And in today's chemical market, information flows rapidly, the global market is interconnected, and prices fluctuate frequently. Therefore, in order to know the exact price range of this "methyl 7 - chloro - 4 - hydroxyquinoline - 2 - carboxylate", it is necessary to check the chemical product trading platform in detail, consult the industry or relevant distributors, and obtain a more accurate figure. It is difficult to rashly assert the price range here.