Methyl 4-chloro-6-methyoxy-quinoline-2-carboxylate

Methyl-4-chloro-6-methoxyquinoline-2-carboxylic acid ester, this is an organic compound. Its main use is more common in the field of organic synthesis.
In the field of organic synthesis, it is often used as a key intermediate. Due to its unique molecular structure, many compounds with different properties and uses can be derived through various chemical reactions. For example, it can participate in nucleophilic substitution reactions, in which chlorine atoms are highly active and can be replaced by various nucleophilic reagents, such as alcohols and amines, to form new carbon-heteroatomic bonds. This process is like building a delicate chemical building block, which can expand the structure and function of molecules.
Furthermore, when constructing complex quinoline derivatives, this compound is used as a basic module. By virtue of its chemical activity of methoxy group and carboxyl ester group, esterification, amidation and other reactions, other functional groups can be introduced to achieve the modification and transformation of the quinoline skeleton. These newly formed derivatives may emerge in the field of medicinal chemistry, such as the development of drug molecules with potential biological activity; or in materials science, such as the preparation of organic materials with specific optical and electrical properties.
In addition, in the process of drug development, it may be an important part of the lead compound. Scientists can carry out structural modification and optimization according to their structural characteristics, in the hope of finding drug candidates with better pharmacological activity, higher selectivity, and lower toxic and side effects.
In short, methyl-4-chloro-6-methoxyquinoline-2-carboxylate plays a crucial role in many fields such as organic synthesis, drug development, and materials science. It is like a delicate key in the chemical world, opening the door to various novel compounds and practical materials.

There are various ways to synthesize methyl 4-chloro-6-methoxyquinoline-2-carboxylic acid esters. One of the common methods is to obtain a multi-step reaction with suitable starting materials.
The first step, or an optional compound containing quinoline structure, needs to reserve a modifiable group at a specific position. Starting with a quinoline derivative, under appropriate reaction conditions, chlorine atoms are introduced to its 4-position. In this step, a suitable chlorination reagent, such as a chlorine-containing halogen, is often required to achieve accurate chlorination of the 4-position in the presence of the catalyst. The catalyst used, or a metal salt, can promote the electrophilic substitution of chlorine atoms, so that the reaction proceeds in the desired direction.
Second step, for the 6-position, methoxy group is to be introduced. Methoxylation reagents can be selected, such as the combination of iodomethane and alkoxide. In an alkaline environment, the alkoxide reacts with iodomethane to form a methoxy negative ion, and then nucleophilic substitution of the quinoline 6-position, successfully introducing methoxy group. Controlling the reaction temperature, time and reagent dosage can improve the yield and selectivity of this step of the reaction.
Last step, synthesis of carboxylic acid ester moiety. The esterification reaction is carried out by heating the quinoline intermediate containing carboxyl groups with methanol under the action of esterification catalysts such as concentrated sulfuric acid. Concentrated sulfuric acid can catalyze the dehydration and condensation of carboxylic acids and alcohols to form the target methyl 4-chloro-6-methoxyquinoline-2-carboxylic acid ester. After the reaction is completed, it is separated and purified by methods such as column chromatography, recrystallization, etc., to obtain a pure product.
In addition, there are other synthesis paths, or from different starting materials, through different reaction sequences and conditions, to achieve the synthesis of this target product, but the reaction needs to be precisely controlled to obtain satisfactory results.

Methyl 4-chloro-6-methoxyquinoline-2-carboxylic acid ester, this is an organic compound. Looking at its physical and chemical properties, the first word appearance, at room temperature or crystalline solid, fine texture, color or nearly white, soft luster. Its melting point is also an important physical property. After precise determination, it is about a specific temperature range. This temperature can gradually melt the substance from a solid state to a liquid state. This property is a key guide in the process of separation, purification and identification.
Re-discussion of solubility, in common organic solvents such as ethanol and acetone, its solubility is quite good, and it can be uniformly dispersed to form a clear solution. This is due to the interaction between the molecular structure and the solvent molecules. However, in water, the solubility is poor, because the hydrophobic part of the molecule accounts for a large proportion, and the force with water molecules is weak.
Chemically, the compound has a certain reactivity. The chlorine atom in the molecule is highly active and can participate in nucleophilic substitution reactions. The aromatic ring structure endows it with certain stability, but it can also undergo electrophilic substitution under specific conditions, such as suitable catalysts and reaction temperatures, and introduce new groups at specific positions in the aromatic ring. Methoxy groups and carboxyl ester groups also affect the electron cloud distribution and reactivity of the molecule as a whole. Ester groups can be hydrolyzed, and corresponding carboxylic acids and alcohols are generated under acid or base catalysis. This hydrolysis reaction may be important in organic synthesis and drug metabolism. In conclusion, the physical and chemical properties of methyl 4-chloro-6-methoxyquinoline-2-carboxylic acid esters lay the foundation for their application in organic synthesis, drug development and other fields.

The market price of methyl-4-chloro-6-methoxyquinoline-2-carboxylate is difficult to determine. This is due to the vagaries of market conditions, and many factors will affect its price.
Looking at the market in the past, the price of chemical materials often fluctuated due to the abundance of raw materials. If the supply of raw materials required for the synthesis of this compound is sufficient, the price may stabilize and be slightly lower; on the contrary, if raw materials are scarce, the price will rise. As Tiangong Kaiwu said, the amount of material depends on its value. Changes in the origin and output of raw materials will also lead to different prices.
Furthermore, market demand is also key. If there is a strong demand for methyl-4-chloro-6-methoxyquinoline-2-carboxylic acid ester in many industries, such as medicine, chemical industry and other fields, merchants will see benefits and may increase prices; if there is little demand, merchants may sell it for promotion or reduce its price.
The difficulty of the process also affects the price. If the process of preparing this compound is complicated, it requires superb skills and special equipment, and the cost increases, the price will be higher; if the process is simple, the cost is controllable, and the price may be more accessible to the people.
In addition, changes in the current situation, tax adjustments, etc., will affect the price of this product in the market. Therefore, in order to know its exact price, it is necessary to gain real-time insight into the market and consider various factors in order to obtain it.

The Quality Standard of methyl-4-chloro-6-methoxyquinoline-2-carboxylic acid ester is an important consideration in terms of its quality.
In terms of appearance, this compound should be uniform in appearance, free of obvious impurities and abnormal color. Either white to off-white crystalline powder, or with a specific crystal form, it should be clean and free of foreign matter mixing.
Purity is the key Quality Standard. Precise analytical methods such as high performance liquid chromatography (HPLC) are required to strictly determine its purity. In general, the purity should reach a very high level, often requiring not less than 98%, or even higher, to ensure that the compound is of good quality and the impurity content is low, so as to avoid adverse effects of impurities on subsequent applications.
The detection of related substances cannot be ignored. With the help of HPLC and other means, carefully detect the relevant impurities that may exist. The type and content of impurities should be strictly controlled, and the content of each impurity should be limited to a very low level to prevent interference with the properties and application efficiency of the compound.
Melting point is also one of the Quality Standards. Accurately determine its melting point. When the melting point of the compound is in a specific temperature range, this range can be accurately measured by instruments such as melting point meters, and the range should be in line with established standards to characterize the stability and purity of its material structure.
Moisture content is also critical. It can be determined by suitable methods such as Carl Fischer's method. The moisture content needs to be controlled within a certain limit. Excessive moisture or the stability of the compound will be damaged, causing adverse reactions such as hydrolysis. Therefore, the moisture content should usually be lower than a certain specified value.
In addition, the residual solvent content also needs to be concerned. Use gas chromatography (GC) and other techniques to detect possible residual organic solvents, such as methanol, ethanol, etc. The residual solvent content must strictly comply with relevant regulations and standards to ensure the safety and quality reliability of the compound.
The above Quality Standards are interrelated and restrict each other, and are all key elements to ensure the excellent quality and stable performance of methyl-4-chloro-6-methoxyquinoline-2-carboxylate.