Isoquinoline-5-sulfonyl chloride HCl

Isoquinoline-5 '-sulfonyl chloride hydrochloride is a compound in organic chemistry. It is active, and the sulfonyl chloride group has strong electrophilicity, which is easy to react with nucleophilic reagents. In contact with water, it hydrolyzes to produce isoquinoline-5' -sulfonic acid and hydrogen chloride. This hydrolysis reaction occurs quickly due to the high reactivity of sulfonyl chloride.
In the field of organic synthesis, it is often a reagent for introducing sulfonyl groups. It can perform nucleophilic substitution reactions with alcohols and amine nucleophilic reagents to form corresponding sulfonate and sulfonamide compounds. In reaction with alcohols, under alkali catalysis, sulfonyl chloride is replaced by alkoxy groups to obtain sulfonate esters. In reaction with amines, sulfonyl chloride interacts with amino groups to form sulfonamides. This reaction is a commonly used method for the preparation of sulfonamide compounds.
Its hydrochloride form can increase the solubility of the compound in polar solvents and help it participate in homogeneous reactions. However, due to its acidic nature, in the reaction system, it may be necessary to consider its influence on other reactants and reaction conditions. When storing, it is necessary to avoid water and moisture to prevent its hydrolysis and deterioration, and to ensure the stability of its chemical properties for subsequent organic synthesis reactions.

Isoquinoline-5-sulfonyl chloride (HCl) is widely used. In the field of organic synthesis, it is a key reagent and often participates in the construction of sulfonyl-containing compounds. Gain sulfonyl chloride groups are highly reactive and can react with many nucleophilic reagents, such as alcohols and amines.
Taking the reaction with alcohols as an example, sulfonate esters can be formed. These compounds are used in medicinal chemistry or as intermediates with specific biological activities, which can be used to develop new drugs. When reacted with amines, sulfonamides are formed. Many sulfonamides exhibit antibacterial, anti-inflammatory and other pharmacological properties, which are of great significance in the process of drug development.
In the field of materials science, with the help of isoquinoline-5-sulfonyl chlorohydrochloride reactions, polymer materials with special properties may be prepared. For example, by reacting with polymers containing specific functional groups, new properties of materials can be imparted, such as improved solubility and thermal stability.
Furthermore, in the field of chemical analysis, it is also useful. Due to its unique chemical structure and reactivity, it can be used as an analytical reagent for the detection or quantitative analysis of specific compounds. Through specific reactions with it, accurate analysis of the target can be achieved according to the characteristics of the reaction products.

To prepare isoquinoline-5-sulfonyl chloride hydrochloride, the method is as follows:
First take isoquinoline as the base material, and in the step of sulfonation, co-warm it with fuming sulfuric acid or concentrated sulfuric acid. At this time, sulfate is cleverly attached to the fifth position of isoquinoline to obtain isoquinoline-5-sulfonic acid. During the reaction, the temperature and duration need to be precisely controlled. Because the temperature is too high or the duration is too long, it may cause side reactions and cause other positions to be sulfonated.
The isoquinoline-5-sulfonic acid is transferred to the chlorination stage. Often accompanied by chlorination agents such as sulfoxide chloride and phosphorus oxychloride. If thionyl chloride is used, after the two are miscible, heat it up a little to promote it. The thionyl chloride first interacts with the hydroxyl group in the sulfonic acid, and the chlorinated hydroxyl group escapes sulfur dioxide and hydrogen chloride gas, and finally obtains isoquinoline-5-sulfonyl chloride. After this step, the excess thionyl chloride can be removed by distillation. After
, to obtain isoquinoline-5-sulfonyl chloride, put the resulting isoquinoline-5-sulfonyl chloride in a suitable solvent, such as dichloromethane, and pass it into dry hydrogen chloride gas. The nitrogen atom in isoquinoline-5-sulfonyl chloride has a lone pair electron, and the hydrogen ion in hydrogen chloride is combined to form the corresponding hydrochloride salt. After the reaction, pure isoquinoline-5-sulfonyl chloride was obtained by evaporation of solvent, crystallization and other methods. In the whole process, the control of conditions, the proportion of materials, and the purification method are all key, which are related to the purity and yield of the product.

Isoquinoline-5-sulfonyl chlorohydrochloride, when storing and transporting this compound, all precautions must be carefully checked.
It is very active and easy to react with various substances. When storing, the first environment is dry. If it is in a humid place, water vapor is easy to encounter, or cause hydrolysis and damage its quality. Therefore, it is necessary to choose a dry, cool and well-ventilated place to avoid direct sunlight, sunlight heat or chemical changes caused by it, which will damage its purity.
And this compound is corrosive. When transporting, the packaging must be sturdy and strict. The container used should be resistant to its corrosion to prevent leakage. If the package is damaged, the liquid will flow out, which will not only damage the goods, but also endanger the transporter and the surrounding environment. When handling, it must be done gently to avoid collision and vibration to prevent damage to the package.
Furthermore, the operator should also strictly abide by the procedures. Protective equipment, such as protective clothing, gloves and goggles, must be worn to avoid contact with it and damage to the skin and eyes. After the operation, it is also necessary to clean your hands and face to remove any remnants.
During transportation, temperature control is also important. Overheating or overcooling may cause this compound to change. Therefore, it should be kept in a suitable temperature range according to its characteristics. If the transportation time is long, it is necessary to check its condition frequently to prevent problems before they occur, so that isoquinoline-5-sulfonyl chloride can be safely stored and transported.

Isoquinoline-5-sulfonyl chloride HCl, that is, isoquinoline-5-sulfonyl chloride hydrochloride, the price of this product in the market is difficult to determine. The price often varies according to the supply and demand of the city, the quality of the quality, the complexity of the system and the seller's policy.
Looking at the prices of the items described in Tiangong Kaiwu in the past, they all change with many factors. In today's city, if the supply of isoquinoline-5-sulfonyl chloride hydrochloride exceeds the demand, the price may drop slightly; if the demand exceeds the supply, the price will tend to rise. And the higher the quality, the higher the price. If its preparation requires complicated methods and precious materials, the price is also not cheap.
I have heard that the price of this product per gram may be between tens of yuan and hundreds of yuan. However, this is only an approximation, and the actual price may vary greatly. When purchasing in bulk, the seller may give a discount due to the quantity, and the price may be reduced. For small retail sales, the price may be higher. In different places, the price varies due to transportation costs, taxes, etc. In order to know the exact price, you need to consult various suppliers and compare their prices and quality in detail before you can get a suitable price.