Isoquinoline-4-carbaldehyde

Isoquinoline-4-formaldehyde has unique chemical properties. This substance contains an aldehyde group and has typical properties of the aldehyde group.
In case of strong oxidants, such as potassium permanganate, the aldehyde group is easily oxidized to a carboxyl group to obtain isoquinoline-4-carboxylic acid. This reaction is just like a warrior who is a strong enemy on a dangerous road, and the aldehyde group cannot be changed by strong oxidation.
It can also react with alcohols under acid catalysis. The carbonyl group in the aldehyde group condenses with the alcohol hydroxyl group to form an acetal structure. This process is like a clever splicing of different parts to build a new chemical structure.
In organic synthesis, it is often used as a key intermediate. Due to its structure containing nitrogen heterocycles and aldehyde groups, it can participate in a variety of reactions and build complex organic molecules, just like the cornerstone of building a delicate castle.
Isoquinoline-4-formaldehyde and ammonia derivatives, such as hydroxylamine, hydrazine, etc., can condensate to form new nitrogen-containing compounds. This reaction is like the fusion of different elements to derive new substances.
It can also participate in nucleophilic addition. The aldehyde carbonyl is the electrophilic center, and nucleophilic reagents such as Grignard reagents can attack it, increase the carbon chain, and expand the molecular structure. This is a common strategy for organic synthesis to grow carbon chains, like adding bricks and mortar to molecules, making them more complex and diverse.

The common synthesis methods of isoquinoline-4-formaldehyde are as follows:
First, isoquinoline is used as the starting material. First, the Vilsmeier-Haack reagent composed of mild formylation reagents, such as N, N-dimethylformamide (DMF) and phosphorus oxychloride (POCl 🥰). At low temperature, the isoquinoline is slowly added to the reaction system containing Vilsmeier-Haack reagent, and the reaction is smooth, gradually warmed to a moderate temperature and continuously stirred. During this process, the reagent undergoes an electrophilic substitution reaction with isoquinoline, and a formyl group is introduced at the 4th position to generate isoquinoline-4-formaldehyde. After the reaction is completed, the product is purified by means of neutralization, extraction, column chromatography and other means.
Second, a suitable halogenated isoquinoline is used as the raw material. Such as 4-halogenated isoquinoline, which reacts with metal magnesium to prepare Grignard's reagent. The Grignard reagent is slowly dropped into ice-cold anhydrous DMF, nucleophilic addition reaction occurs, and then hydrolyzed to obtain isoquinoline-4-formaldehyde. After the reaction is completed, the product is purified by separation, drying of the organic phase, distillation or recrystallization.
Third, starting from the benzo ring system containing suitable substituents. For example, the specific substituted benzofuran or benzothiophene derivatives, through multi-step reaction to construct the isoquinoline ring and introduce the formyl group at the same time. This approach often requires multi-step reaction, involving many steps such as cyclization, substitution, oxidation, etc. Each step requires precise control of the reaction conditions and reagent dosage to achieve high selectivity and yield. After each step of reaction, corresponding separation and purification operations are also required to finally obtain the target product isoquinoline-4-formaldehyde.

Isoquinoline-4-formaldehyde is useful in the fields of medicine and materials.
In the field of medicine, it is often the key raw material for the creation of drugs. Because of its unique chemical structure, it can interact with many targets in organisms. Taking the development of anti-cancer drugs as an example, its structure can be modified to synthesize compounds that target specific cancer cell functions, so as to interfere with the metabolism and proliferation of cancer cells to inhibit tumor growth. For example, in the research of nervous system drugs, it can be used as a lead compound to optimize the structure to produce drugs that regulate neurotransmitter receptors to treat neurological diseases such as Parkinson's and Alzheimer's.
In the field of materials, isoquinoline-4-formaldehyde is also quite useful. In the preparation of fluorescent materials, it can be introduced into polymers or small molecule systems to give the material unique optical properties. Because of its structure, it can cause intramolecular charge transfer or emit specific wavelength fluorescence, which makes the material have potential applications in fluorescence sensors, biological imaging, etc. In sensor applications, it can respond to the presence or concentration changes of specific substances and emit fluorescent signals to achieve rapid detection of targets. In the field of biological imaging, its fluorescence properties may help scientists observe the microstructure and physiological processes in organisms.
Furthermore, in the field of organic synthesis chemistry, isoquinoline-4-formaldehyde is an important synthesis intermediate. Chemists can use a variety of organic reactions, such as nucleophilic addition and condensation, to convert them into organic compounds with more complex and diverse structures, thereby expanding the variety of organic compounds and contributing to the development of organic synthesis chemistry.

I look at your question, but I am inquiring about the market price of isoquinoline-4-formaldehyde. However, this price is not constant and is affected by various factors.
First, the trend of supply and demand is important. If this material is widely needed and used in many fields such as pharmaceuticals and chemical synthesis, the price will rise if there are many applicants and few suppliers; on the contrary, if the supply exceeds the demand, the price may drop.
Second, the cost of raw materials is also the key. The production of isoquinoline-4-formaldehyde requires all kinds of raw materials, and the price of raw materials rises and falls, directly affecting the price of its finished products. If the raw materials are rare and the cost increases, the price will rise.
Third, the simplicity of the production method and process also affects the price. The delicate and advanced method may reduce the cost, increase the yield, and cause the price to stabilize or drop; if the process is complicated, time-consuming and laborious, the price may be high.
Fourth, the state of market competition should not be ignored. If there are many competitors in the same industry, the competition is fierce, and it is a competition for market share, or there is a promotion of price reduction; if the market is monopolized and there are few suppliers, the price can be in the minority, or it can remain high.
As for the exact price, it is difficult to hide it. To know the exact market price, when you check the chemical product trading platform in detail, consult the industry's Jia expert, or negotiate with relevant suppliers, you can get the current price.

Isoquinoline-4-formaldehyde is an organic compound. To know its safety and toxicity, it is necessary to consider it carefully.
Looking at its chemical properties, isoquinoline-4-formaldehyde has a specific molecular structure, which is related to many chemical reactions and biological activities. In terms of safety, its physical properties such as appearance, smell, etc., can be initially observed. If it is a volatile substance, it can spread in the air, or come into contact with human respiratory tract, skin, etc., it is necessary to prevent irritation.
As for toxicity, consider its effect on organisms. At the cellular level, it may affect cell metabolism, proliferation, or even cause cell damage. In animal experiments, observe the changes in behavior and physiological indicators of experimental animals through oral, percutaneous or inhalation routes to judge their acute toxicity. Long-term exposure requires observation of chronic toxicity, such as the effect on organ function.
However, due to the lack of detailed experimental data, it is difficult to determine the specific degree of safety and toxicity. Or compounds with similar structures can be compared, but they are only speculations. To obtain an accurate conclusion, it is necessary to rely on professional toxicology experiments, carefully investigate the dose-effect relationship, mechanism of action, etc., to know its impact on organisms and the environment in different scenarios, in order to determine the safe use method.