Isoquinoline-3-carboxylic acid methyl ester

Isoquinoline-3-carboxylate methyl ester, which has a wide range of uses, is often a key synthetic raw material in the field of medicinal chemistry. Many drug development relies on it as a starting material and undergoes a series of chemical reactions to build molecular structures with specific pharmacological activities. For example, in the synthesis pathway of some drugs with anti-tumor, antibacterial or nervous system regulation effects, isoquinoline-3-carboxylate methyl ester may play an indispensable role in the generation of pharmacophore that precisely binds to target proteins.
In the field of organic synthesis, due to its unique chemical structure, it can be used as a key intermediate and participate in the construction of heterocyclic compounds. With its activity check point, it can react with a variety of reagents such as nucleophilic substitution and electrophilic addition, and realize the gradual construction of complex organic molecules, providing the possibility for the synthesis of novel organic materials or natural product analogs.
In addition, in the field of materials science, after specific modifications, it may endow materials with unique photoelectric properties, which can be used in the preparation of materials such as organic Light Emitting Diodes and sensors. Through the relationship between its structure and properties, new materials with specific functions can be developed. In short, methyl isoquinoline-3-carboxylate has important application value in many scientific fields, providing many opportunities for scientific research and industrial development.

Isoquinoline-3-carboxylic acid methyl ester is one of the organic compounds. Its physical properties, first properties, at room temperature, often appear white to light yellow crystalline powder, which is the visually discernible state. Looking at its melting point, it is about a specific temperature range. This temperature is the critical point for the substance to change from solid to liquid. It is the inherent characteristics of the compound, which is very helpful for its identification and purity determination.
When it comes to solubility, it shows a certain solubility in common organic solvents, such as ethanol and chloroform. Ethanol, mild in nature, can partially dissolve with isoquinoline-3-carboxylic acid methyl ester to form a uniform dispersion system; chloroform, due to its unique molecular structure and polarity, can also interact with the compound to promote dissolution. However, in water, its solubility is poor, because the polarity of water and the molecular structure of the organic substance are quite different, it is difficult to form an effective interaction between the two, so it is difficult to dissolve.
Its density is also one of the important physical properties, characterizing the mass of the substance per unit volume. This value reflects the degree of molecular accumulation. Compared with similar compounds, the relationship between its structure and properties can be observed. In addition, the compound has a certain degree of stability and can be stored for a long time in a normal temperature, pressure, dark and dry environment. However, under extreme conditions such as strong acid, strong alkali or high temperature, its structure may change, which is also necessary to understand its physical properties and storage conditions.

To prepare isoquinoline-3-carboxylic acid methyl ester, there are three methods.
One is to start with isoquinoline-3-carboxylic acid, so that it is co-heated with methanol under acid catalysis, and the esterification reaction is carried out. If sulfuric acid is used as the catalyst, at an appropriate temperature, the two interact, and the carboxyl group of the carboxylic acid and the hydroxyl group of the methanol dehydrate and condensate to obtain the target product. This reaction condition is mild and convenient to operate. However, it is necessary to pay attention to the corrosiveness of sulfuric acid, and the sulfuric acid needs to be removed after the reaction to prevent affecting the purity of the product.
The second is to use isoquinoline as the starting material, and introduce the carboxyl group at the third position first. The Grignard reagent can be prepared by the Grignard reagent method, isoquinoline and suitable halogenated hydrocarbons, and then reacted with carbon dioxide to introduce the carboxyl group, and then esterified with methanol under acid catalysis. This step is slightly complicated, but it can effectively introduce the carboxyl group at a specific position, which is suitable for the precise requirements of the reaction check point.
Third, the compound containing the isoquinoline structure can be used to achieve through appropriate functional group transformation. For example, the isoquinoline derivative containing a suitable substituent is selected, and after hydrolysis and substitution, the final isoquinoline-3-carboxylic acid methyl ester is obtained. This method requires in-depth knowledge of the structure and reactivity of the starting compound in order to skillfully design the reaction route for efficient synthesis.

The question you are asking is about the market price of isoquinoline-3-carboxylic acid methyl ester. However, this price is not static and is subject to many factors.
First, the price of raw materials fluctuates. The preparation of isoquinoline-3-carboxylic acid methyl ester requires specific raw materials. If the raw materials are scarce or the market supply and demand are unbalanced, the price will change, which will affect the price of isoquinoline-3-carboxylic acid methyl ester.
Second, the production technology is also critical. Advanced production technology can improve yield and reduce costs; if the process is backward, the cost will be high, and the price of the product will also be high.
Third, the supply and demand of the market is necessary. If the demand is strong and the supply is small, the price will rise; if the supply exceeds the demand, the price will drop.
Fourth, regional differences also have an impact. Different places, due to transportation costs, market environment, etc., prices also vary.
To know the exact price, you can visit the chemical product trading platform. There are many merchants on it, and the price is often listed. Or consult chemical raw material suppliers, who are familiar with market dynamics and can tell the latest price. However, the price obtained is only for reference. In actual transactions, it is still necessary to negotiate the amount and terms of the transaction to get the exact price.

Isoquinoline-3-carboxylic acid methyl ester is an organic compound. When storing and transporting, pay attention to the following numbers:
First, the storage environment is the most critical. It should be placed in a cool, dry and well-ventilated place. Because it may be sensitive to heat, if the temperature is too high, it may cause chemical reactions and cause it to deteriorate. Humid environment is also not good, due to moisture or hydrolysis and other reactions, its chemical properties will be damaged. Therefore, the warehouse should maintain a suitable temperature and humidity, away from heat sources and water sources.
Second, avoid contact with oxidants, acids, alkalis and other substances. This compound has a specific chemical activity. When it encounters an oxidizing agent or a violent oxidation reaction, it is at risk of combustion and explosion. When it encounters an acid or alkali, or an acid-base reaction occurs, it destroys its structure and changes its chemical properties. When storing, be sure to separate it from such substances.
Third, the packaging must be sturdy during transportation. Appropriate packaging materials should be selected to ensure that it does not break and leak when it is bumped or vibrated. Common examples are well-sealed glass or plastic bottles, which are protected by strong cartons or wooden boxes. When loading and unloading, it should also be handled with care to avoid damage to the packaging caused by brutal operations.
Fourth, clear identification is indispensable. The name, nature, hazard characteristics and emergency treatment methods of the compound should be clearly marked on the packaging. In this way, in all aspects of storage and transportation, staff can quickly understand its characteristics, and in case of emergencies, they can respond in a timely and correct manner.
In short, when storing and transporting isoquinoline-3-carboxylic acid methyl ester, careful attention should be paid to the environment, material contact, packaging and labeling to ensure its safety and quality.