Name | Hydroxyquinoline |
Molecular Formula | C9H7NO |
Molar Mass | 145.16 g/mol |
Appearance | Pale yellow to brown solid |
Odor | Characteristic |
Solubility In Water | Slightly soluble |
Solubility In Organic Solvents | Soluble in ethanol, ether, chloroform |
Melting Point | 76 - 78 °C |
Boiling Point | 267 - 269 °C |
Pka | 9.98 |
Density | 1.232 g/cm³ (20 °C) |
Cas Number | 148-24-3 |
What are the main uses of Hydroxyquinoline?
Hydroxyquinoline has a wide range of uses. First, in the field of medicine, it has antibacterial and antifungal properties. It can be used as a medicine to treat skin diseases, such as ringworm, eczema, etc., with its antibacterial properties, inhibit the growth of pathogens, and promote healthy skin recovery. Second, it is also widely used in agriculture. It can be used as a fungicide to protect plants from diseases, ensure the robust growth of crops, and increase harvests. Furthermore, in the chemical industry, hydroxyquinoline is an important raw material. It can be used in synthetic dyes to make the dyed color bright and fastness good; it is also used in synthetic rubber to improve the performance of rubber and increase its durability. And because of its chelating effect on metal ions, in the field of metal corrosion inhibition, it can prevent metal corrosion and extend the service life of metal materials. In short, hydroxyquinoline plays a key role in medicine, agriculture, chemical industry and many other aspects, and its effectiveness is significant and indispensable.
What are the common side effects of Hydroxyquinoline?
Hydroxyquinoline has many effects such as medicine and chemical industry, but it also has some common side effects.
First, on the skin, or cause contact dermatitis. If people touch it, the skin often causes erythema, itching, and swelling, and the pain is unbearable. This is because individuals are sensitive to it and the skin's defense can rise up to resist, so this is the case.
Second, it is related to the eye. If it is not carefully entered into the eye, it can cause irritation. In light cases, the eyes feel uncomfortable, tingling, and tearing; in severe cases, it may damage the tissue of the eye and endanger the vision. All because of the chemical properties of hydroxyquinoline, which are contrary to the environment in the eye, it irritates all parts of the eye.
Furthermore, when taken internally, it also affects the digestive system. Common symptoms of nausea, vomiting, and abdominal pain. Because of the delicate stomach, when encountering this chemical, the transportation and chemical functions are disturbed, the stomach gas is reversed, and the intestines are cramped and painful.
In addition, long-term or excessive use may also affect the nervous system. People may experience headache, dizziness, fatigue, and severe cases may cause mental confusion. The delicate balance of the nervous system is destroyed due to the intervention of hydroxyquinoline, and nerve conduction and metabolism are disturbed.
And hydroxyquinoline also has potential harm to the blood system, or causes changes in some components of the blood, affecting the normal coagulation and immune functions of the human body.
When using hydroxyquinoline, it is necessary to exercise caution and carefully monitor its side effects to prevent physical damage.
What are the differences in the application of Hydroxyquinoline in different industries?
Hydroxyquinoline is used in various industries and has different uses. In the pharmaceutical industry, it is a raw material for the production of antibacterial and antimalarial drugs. Cover because of its antibacterial and antifungal properties, it can make ointments and lotions to treat skin infections; and it can help antimalarial drugs to remove malaria parasites and save patients from malaria.
In agriculture, it is a plant protection agent. It can prevent crops from falling ill and ensure their healthy growth. Its antibacterial ability prevents disease bacteria from attacking, increases crop yield and quality, and is the guarantee of agricultural harvest.
In the material industry, it is also widely used. It can be used as a metal corrosion inhibitor to protect metals from corrosion and prolong their life. It can also be used to make luminescent materials, endowing materials with unique optical properties, and used in display, lighting and other fields.
In the field of chemical industry, it is an intermediate for organic synthesis. With its structural characteristics, through chemical reaction, a variety of organic compounds are produced, which enriches the variety of chemical products.
In summary, hydroxyquinoline has unique functions in medicine, agriculture, materials, chemical industry and other industries. According to the needs and characteristics of the industry, it can develop its growth and become a boost for the development of various fields.
What is the market outlook for Hydroxyquinoline?
Hydroxyquinoline is a chemical substance. In today's market, its prospects are promising, and it is also in high demand because of its wide range of uses.
Hydroxyquinoline is effective in the field of medicine. It can be an antibacterial and antifungal agent and can help physicians treat various diseases. The demand for it in the pharmaceutical industry continues to grow. And with the increasing emphasis on health in the world, the pharmaceutical industry continues to expand, and hydroxyquinoline plays an increasingly important role in pharmaceutical manufacturing.
In the agricultural field, hydroxyquinoline is also very useful. It can be used as a plant growth regulator to help plants thrive, resist diseases, and improve crop yield and quality. Nowadays, agriculture is moving towards modernization and science, and the demand for various high-efficiency agricultural additives is increasing day by day. Hydroxyquinoline has also taken advantage of this trend to find a wide range in the agricultural market.
Furthermore, in the field of material science, hydroxyquinoline can participate in the preparation of luminescent materials. With the rapid development of science and technology, there is a large demand for new materials in electronic display and other industries. Hydroxyquinoline can meet some material performance requirements due to its unique chemical properties, and its application in this field is also on the rise.
In terms of market supply, many chemical companies have paid attention to and invested in the production of hydroxyquinoline due to demand. However, in order to ensure high product quality and stable supply, enterprises still need to improve their production processes and improve their technical level.
In summary, hydroxyquinoline is widely used in medicine, agriculture, materials, and other fields, and demand continues to rise. The market prospect is promising, and it is expected to bloom more brilliantly in the future chemical market.
What are the synthesis methods of Hydroxyquinoline?
The synthesis method of hydroxyquinoline has been explored by many scholars in the past, but the methods are different, and it is briefly described today.
First, quinoline is used as the starting material and obtained by oxidation. In an appropriate reaction vessel, quinoline is placed and a suitable oxidant, such as hydrogen peroxide, is added. Control the reaction temperature, duration and proportion of the reactants to introduce hydroxyl groups into the quinoline molecule. This process needs to be finely regulated, and unnecessary by-products are produced due to oxidation reactions or excessive oxidation.
Second, it is synthesized by Skraup reaction variants. Aniline, glycerol, etc. are used as raw materials, supplemented by sulfuric acid and appropriate catalysts, such as arsenic pentoxide. In the reaction, a series of complex cyclization reactions are first performed to form a quinoline ring, and then hydroxyl groups are introduced in subsequent steps. This reaction condition is more harsh, sulfuric acid is highly corrosive, and the catalyst used may be toxic, so extra caution is required during operation.
Third, halogenated quinoline is used as a substrate and a hydroxyl group is introduced through a nucleophilic substitution reaction. Halogenated quinoline reacts with hydroxyl-containing nucleophiles, such as alkali metal hydroxides, under suitable solvents and reaction conditions. The hydroxyl group of the nucleophilic reagent replaces the halogen atom to obtain hydroxyquinoline. However, the preparation of halogenated quinoline may require a multi-step reaction, and the selectivity of the nucleophilic substitution reaction also needs to be properly considered.
All methods of synthesis have their own advantages and disadvantages. In practical application, the choice should be made carefully according to factors such as the purity, yield and cost of the desired product.