Ethyl7-bromo-1-cyclopropyl-8-(difluoromethoxy)-1,4-dihydro-4-oxoquinoline-3-carboxylate

Ethyl 7 - bromo - 1 - cyclopropyl - 8 - (difluoromethoxy) - 1,4 - dihydro - 4 - oxoquinoline - 3 - carboxylate, this is a quinolone compound. Looking at its name, its chemical structure can be gradually analyzed according to the nomenclature of organic chemistry.
"Ethyl", which is ethyl, it can be seen that this compound contains ethyl group and its structure is - CH ² CH. "7 - bromo" indicates that there is a bromine atom (Br) attached to the quinolone parent nucleus at position 7. " 1-Cyclopropyl ", that is, the No. 1 position is connected with a cyclopropyl group, and the cyclopropyl group is a ternary carbon ring structure." 8- (difluoromethoxy) ", indicating that the No. 8 position is connected with a difluoromethoxy group (-OCHF ³)." 1,4-dihydro-4-oxoquinoline-3-carboxylate ", revealing that the compound has a 1,4-dihydro-4-oxoquinoline as the parent nucleus, and has a carboxylate group (-COOCH -2 CH) at the No. 3 position.
In summary, the chemical structure of this compound is based on quinolone as the parent nucleus, and ethyl, bromine atom, cyclopropyl, difluoromethoxy, and carboxylate ethyl groups are attached at specific positions.

Ethyl7-bromo-1-cyclopropyl-8- (difluoromethoxy) -1,4-dihydro-4-oxoquinoline-3-carboxylate, Chinese name or 7-bromo-1-cyclopropyl-8- (difluoromethoxy) -1,4-dihydroquinoline-3-carboxylate. This substance is an important member of quinolones and is widely used in the field of medicine, mainly in the research and development of antibacterial drugs.
First, in the creation of antibacterial drugs, it is a key intermediate. After a series of chemical reactions, it can combine with many active groups to construct quinolones with specific antibacterial activities. Due to its structural characteristics, it can efficiently inhibit bacterial DNA rotatase or topoisomerase IV, which in turn interferes with the replication, transcription and repair of bacterial DNA, achieving antibacterial effect. Such antibacterial drugs have a wide antibacterial spectrum and have significant inhibitory effects on Gram-positive and Gram-negative bacteria, such as Escherichia coli, Staphylococcus aureus and other common pathogens.
Second, in the study of medicinal chemistry, researchers explore the relationship between structure and activity by modifying and modifying its structure. By changing the type, position and quantity of cyclopropyl, difluoromethoxy and other substituents, the antibacterial activity, pharmacokinetic properties and safety of the drug can be regulated. After structural optimization, new quinolone antibacterial drugs with stronger antibacterial activity, lower drug resistance and fewer side effects may be developed.
Third, in the process of new drug development, it can be used as a starting material to synthesize quinolone derivatives with novel structures. After activity screening and evaluation, lead compounds with new mechanisms of action or unique antibacterial properties may be discovered, which will open up a new direction for the research and development of antibacterial drugs and is of great significance for solving the current severe bacterial resistance problem.

Ethyl 7-bromo-1-cyclopropyl-8- (difluoromethoxy) -1,4-dihydro-4-oxoquinoline-3-carboxylate is an organic compound, and its preparation process is as follows:
The starting material selects quinoline compounds containing specific substituents. The first step of the reaction is to add a halogenating agent, such as a brominating agent, such as N-bromosuccinimide (NBS), to a suitable organic solvent, such as dichloromethane, N, N-dimethylformamide, etc., under mild heating or light conditions, the quinoline ring is brominated at a specific position. In this case, bromine atoms are introduced at position 7. This step requires precise control of the reaction temperature and time. If the temperature is too high or the time is too long, it may cause side reactions such as excessive bromination.
In the next step, the bromine-containing compound is reacted with the cyclopropylation reagent in an alkaline environment. Commonly used bases such as potassium carbonate, sodium carbonate, etc., and the cyclopropylation reagent can choose cyclopropyl halide, such as cyclopropyl bromide. The reaction is carried out under heated reflux conditions to allow the cyclopropyl group to be successfully replaced to the quinoline ring 1 position. This step should pay attention to the pH of the reaction system. Too strong or too weak alkalinity may affect the reaction process and yield. < Br >
In another step, to introduce the 8-position (difluoromethoxy) group, a difluoromethoxylation reagent is used, such as difluoromethyl halide reacts with sodium alcohol (such as sodium methoxide) to form difluoromethoxy negative ions, and then reacts with the previous product. This step requires an anhydrous environment, because water will react with the reagent to cause its inactivation, and the reaction conditions must be strictly controlled to ensure the accurate introduction of the group.
In the last step, the 3-carboxyl group of the quinoline ring is esterified with a carboxylic acid ethylation reagent, such as ethanol and corresponding acylation reagent, under the action of a catalyst such as concentrated sulfuric acid or p-toluenesulfonic acid, to generate the target product Ethyl 7-bromo-1-cyclopropyl-8 - (difluoromethoxy) -1,4-dihydro-4-oxoquinoline-3-carboxylate. After the reaction, the high-purity product can be obtained by separation and purification methods such as extraction and column chromatography.

I look at the "Ethyl 7 - bromo - 1 - cyclopropyl - 8 - (difluoromethoxy) - 1,4 - dihydro - 4 - oxoquinoline - 3 - carboxylate" you are inquiring about, this is a complex organic compound. However, it is not easy to know its market price. The cover is affected by many factors because of its price.
First, the purity of this compound has a great impact on the price. If the purity is very high, almost perfect, and there is no impurity interference, the price will be high; if the purity is slightly lower, containing some impurities, the price may drop.
Second, the difficulty of preparation is also the key. If its synthesis requires exquisite skills, complicated processes, and consumes many rare raw materials and long working hours, the price will be high; if the preparation is relatively simple and the cost is controllable, the price will also decrease.
Third, the situation of market supply and demand cannot be ignored. If there are many people who want it, the supply is in short supply, and merchants may raise prices in pursuit of profit; if there is an oversupply, the inventory will be overstocked, and merchants may reduce prices to promote.
Fourth, regional differences also affect prices. In different places, due to differences in transportation costs, tax policies, and market competition, there may be large price differences.
As far as I know, there is no exact specific price to quote. For accurate prices, you can consult chemical reagent suppliers or check in detail on chemical product trading platforms, so that you can obtain current relatively accurate market prices.

Ethyl7 - bromo - 1 - cyclopropyl - 8 - (difluoromethoxy) - 1,4 - dihydro - 4 - oxoquinoline - 3 - carboxylate is an organic compound. During use, all precautions are most important.
First safety protection. This compound may be toxic and irritating. When handling, be sure to wear suitable protective equipment, such as laboratory clothes, gloves and goggles, to prevent skin contact and eye splashing. In case of inadvertent contact, rinse with plenty of water immediately and seek medical treatment according to the specific situation.
Furthermore, pay attention to its chemical properties. The substance may be sensitive to light, heat or specific chemical reagents. When storing, it should be placed in a cool, dry and dark place, away from sources of fire and oxidants, etc., to avoid chemical reactions that may cause deterioration or danger.
During the experimental operation, it is crucial to precisely control the reaction conditions. Factors such as temperature, reaction time and the proportion of reactants can all have a significant impact on the reaction results. Strict operation is required according to established experimental procedures to ensure that the reaction proceeds smoothly and the desired product is obtained.
In addition, since it is an organic compound, it may have a potential impact on the environment. After use, its waste must not be discarded at will. It must follow relevant environmental protection regulations and be properly disposed of to reduce the harm to the environment.
In conclusion, when using Ethyl7 - bromo - 1 - cyclopropyl - 8 - (difluoromethoxy) -1,4 - dihydro - 4 - oxoquinoline - 3 - carboxylate, safety protection, attention to chemical properties, accurate operation and proper disposal of waste cannot be ignored, so as to ensure the safety and effectiveness of the use process.