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What is the main use of ethyl N- (2-ethoxy-1,2-dihydroquinoline) carboxylate?
Ethyl N- (2-ethoxy-1,2-dihydroquinoline) carboxylate (N - (2-ethoxy-1,2-dihydroquinoline) carboxylate ethyl ester) is widely used. In the field of medicinal chemistry, it is often involved in drug synthesis as a key intermediate. Due to its unique molecular structure and specific chemical activity and spatial configuration, it can be used through a series of chemical reactions to construct complex molecular structures with specific pharmacological activities, which can help the development of new drugs.
In the field of materials science, it may be used to prepare materials with specific properties. By participating in polymerization reactions, etc., it imparts unique optical, electrical or mechanical properties to materials, such as improving material fluorescence properties or enhancing material stability, to meet the special needs of different fields for material properties.
In organic synthetic chemistry, as an important synthetic block, it provides an effective path for the synthesis of complex organic compounds. By virtue of its activity check point in the structure, it reacts with a variety of reagents to achieve functional group transformation and molecular skeleton expansion, enriches the variety and structural diversity of organic compounds, promotes the development of organic synthetic chemistry, and lays the foundation for exploring the structure and properties of novel organic compounds.
What are the physical properties of ethyl N- (2-ethoxy-1,2-dihydroquinoline) carboxylate
Ethyl-N- (2-ethoxy-1,2-dihydroquinoline) carboxylate, the physical properties of this substance are quite important, and it is related to its application in many fields.
Its appearance is often specific, or it is crystalline, with a regular geometric shape, crystal clear, like a miniature gem made in heaven; or it is powdery, delicate and uniform, like the micro-dust of cloud and mist sprinkling on the world. Looking at its color, it is either colorless and transparent, pure and free of impurities, highlighting its high-purity characteristics; or it is slightly yellow, just like the light of the early morning sun, giving it a different charm.
Melting point determination is a key indicator of its purity and characteristics. When placed in a precise instrument and slowly heated to a certain temperature, the substance begins to transform from solid to liquid, and this temperature is the melting point. The accurate determination of the melting point is like affixing a unique identity label to the substance, which helps to identify its authenticity and purity.
Boiling point is also an important physical property. Under specific pressure conditions, it is continuously heated to a certain temperature, and the substance changes sharply from liquid to gas, and a large number of bubbles surge out. This temperature is the boiling point. The boiling point not only reflects the strength of its intermolecular forces, but also is an indispensable parameter in separation and purification processes.
Solubility is also the focus of consideration. In different solvents, its performance varies. In polar solvents, such as alcohols, or because of their molecular structure and polarity, they can be moderately dissolved, just like fish swimming in water and fusing with each other; while in non-polar solvents, such as alkanes, because of their polarity differences, or insoluble as oil and water mutual exclusion, clear stratification.
Density can not be ignored. Take a certain amount of the substance, accurately measure its mass and volume, and calculate its density. The value of density is either greater than water, sinking at the bottom of the water, like a stable rock; or less than water, floating on the water surface, like a light thin feather. This property has important guiding significance in the separation and mixing of substances.
The above physical properties, such as bright stars, together outline the unique physical features of ethyl-N- (2-ethoxy-1,2-dihydroquinoline) carboxylate, laying a solid foundation for its application in chemical, pharmaceutical and other fields.
What is the synthesis method of ethyl N- (2-ethoxy-1,2-dihydroquinoline) carboxylate
The method of synthesizing ethyl-N- (2-ethoxy-1,2-dihydroquinoline) -carboxylic acid esters is the field of organic synthetic chemistry. This synthesis often follows a number of paths.
First, it can be started from quinoline derivatives. First, quinoline is introduced into ethoxy group at the 2-position through a specific reaction. In this step, ethoxylation reagents, such as halogenated ethane and corresponding bases, are used in a suitable solvent. Nucleophilic substitution reaction, ethoxy group is attached to the quinoline ring. Subsequently, the resulting 2-ethoxy quinoline is further modified to hydrogenate at the 1,2-position to form a 1,2-dihydroquinoline structure. The hydrogenation reaction can be achieved by catalytic hydrogenation with a noble metal catalyst such as palladium carbon under suitable hydrogen pressure and temperature. Finally, 1,2-dihydro-2-ethoxyquinoline reacts with a reagent containing a carboxyl ethyl ester structure to form an N-linked carboxylic acid ester structure. This reaction may require the assistance of a shrinking agent, such as dicyclohexyl carbodiimide (DCC), to condensate the two to obtain the target product ethyl-N- (2-ethoxy-1,2-dihydroquinoline) -carboxylic acid ester.
Second, it can also be used to construct a quinoline ring. First, suitable raw materials, such as aniline derivatives and ethoxy-containing β-ketoate, are used to construct quinoline rings through condensation reaction. This condensation process, or a series of steps such as cyclization and dehydration, generates 2-ethoxy quinoline. Subsequent to the same method, hydrogenate it to 1, 2-dihydroquinoline, and then introduce the carboxyl ethyl ester structure to obtain the target product. In the
reaction process, the choice of solvent is very important. Commonly used organic solvents such as toluene, dichloromethane, etc., need to be selected according to the reaction characteristics of each step. Temperature and reaction time also need to be carefully controlled to make each step of the reaction effective and improve the yield and purity of the target product. And after each step of the reaction, it is often necessary to separate and purify means, such as column chromatography, recrystallization, etc., to remove impurities and obtain a pure product to meet the needs of subsequent reactions or applications.
What is the price range of ethyl N- (2-ethoxy-1,2-dihydroquinoline) carboxylate in the market?
I do not know the price range of "ethyl + N - (2 - ethoxy - 1,2 - dihydroquinoline) carboxylate" in the market. This compound is not widely known and common, and its price is determined by many factors.
First, the difficulty of preparation is the key factor. If its synthesis requires complex steps, special raw materials or harsh reaction conditions, the cost will be high, and the price will also rise. If the preparation requires rare raw materials or multiple steps of fine reaction, it requires huge manpower and material resources, and the price is naturally expensive.
Second, the market demand has a great impact. If the demand is strong, it is used in important industrial production or popular areas of scientific research, and the merchant may increase the price appropriately according to the demand; on the contrary, there is little demand, and the price may decrease for promotional sales.
Third, purity has a significant impact on price. High purity is often used in high-end scientific research or special industrial purposes, and it is more difficult to prepare, and the price is much higher than that of low-purity products.
Fourth, the supply situation also affects the price. If there are many manufacturers and the supply is sufficient, the price may tend to be reasonable under competition; if only a few manufacturers can produce, the supply is limited, and the price may remain high.
Because I do not know its specific production, demand, purity and supply status, it is difficult to determine its price range. For more information, please consult chemical product suppliers, chemical trading platforms, or relevant scientific research institutions to obtain accurate price information.
What are the storage conditions for ethyl N- (2-ethoxy-1,2-dihydroquinoline) carboxylate?
Ethyl-N- (2-ethoxy-1,2-dihydroquinoline) carboxylate, which is a fine chemical and the like. Its storage conditions are quite important, which is related to the quality and stability of this material.
According to the concept of "Tiangong Kaiwu", each product has its own nature, and there is a way to exist. For ethyl-N- (2-ethoxy-1,2-dihydroquinoline) carboxylate, the first environment is dry. Moisture is easy to cause it to deteriorate. If it is in a humid place, or it causes hydrolysis and other changes, it will damage its purity and utility. Therefore, it is time to choose a dry place, such as a dry warehouse, away from water sources and places where moisture rises. < Br >
Next, the temperature should be appropriate. Excessive temperature may accelerate its chemical reaction, causing decomposition or polymerization, etc.; too low temperature may also affect its physical properties, such as crystal morphology changes. With common sense, it should be stored in a cool place, and the temperature should be controlled between 5 ° C and 25 ° C, so as to ensure the stability of its properties.
Furthermore, it is important to avoid light. Light is the source of energy, or it can stimulate photochemical reactions of this substance, causing structural changes. Therefore, it should be hidden in an opaque container, such as a brown glass bottle or covered with light-shielding packaging, and placed in a place without direct light.
In addition, this substance may have certain chemical activity and needs to be isolated from other substances. Do not co-store with strong oxidants, strong acids, strong bases, etc., to prevent violent reactions and endanger safety and quality.
In general, the storage of ethyl-N- (2-ethoxy-1,2-dihydroquinoline) carboxylate needs to create a dry, cool, dark and isolated environment according to its physical properties, so as to survive for a long time without losing its usefulness.