Ethyl 7 Chloro 8 Cyano 1 Cyclopropyl 6 Fluoro 4 Oxoquinoline 3 Carboxylate
quinoline thiophene imidazole thiazole

ethyl 7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylate

Taiy Chemical

    Specifications

    HS Code

    490598

    Chemical Name ethyl 7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylate
    Molecular Formula C17H12ClFN2O3
    Molecular Weight 348.74
    Appearance Typically a solid (appearance can vary based on purity and preparation)
    Physical State Solid at standard conditions
    Solubility Limited solubility in water, more soluble in organic solvents like DMSO, acetone
    Melting Point Data may vary, needs experimental determination
    Boiling Point Data may vary, needs experimental determination
    Pka Data may vary, related to the acidic/basic nature of functional groups
    Logp Related to lipophilicity, data may vary based on experimental method
    Crystal Structure Can form different crystal structures depending on crystallization conditions

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    As a leading ethyl 7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylate supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the chemical properties of ethyl 7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylate?
    This is the chemical name of ethyl 7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxyquinoline-3-carboxylic acid ester. Its chemical properties are unique and it has the characteristics of multiple groups.
    Looking at its structure, it contains a quinoline ring, which is the key skeleton of many bioactive molecules, endowing the compound with potential biological activity. The 7-chlorine atom is added with polarity and reaction check point. The electronegativity of chlorine makes it possible to participate in reactions such as nucleophilic substitution, or to strengthen the binding by van der Waals force when interacting with biological targets. 8 - Cyanyl groups have strong electron-absorbing properties, which affect the distribution of molecular electron clouds, change their physical and chemical properties, and can also participate in specific chemical reactions, such as hydrolysis to form carboxyl groups. 1 - Cyclopropyl groups add rigidity and three-dimensional structure, or affect the molecular spatial conformation, and may play an important role in the binding of drugs to receptors. 6 - Fluorine atoms have strong electronegativity, which can enhance molecular stability and affect lipophilicity and other properties, and have potential effects on pharmacokinetics. 4 - Oxygen groups in conjugated systems affect molecular electron delocalization and participate in reactions such as electron transfer. The 3-carboxylic acid ethyl ester group has ester properties, can be hydrolyzed and alcoholized, and is an important reaction check point in organic synthesis, or hydrolyzed into carboxylic acids during metabolism in vivo, changing activity and metabolic pathways.
    Overall, this compound is rich in chemical properties due to the coexistence of various groups, and may have considerable research value and application potential in organic synthesis, drug development and other fields.
    What are the uses of ethyl 7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylate
    Ethyl-7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxyquinoline-3-carboxylic acid ester, this is an organic compound. It has a wide range of uses and can be used as a key intermediate for antibacterial drugs in the field of medicine. Antibacterial drugs can resist bacterial intrusion and protect human health. The quinoline carboxylic acid structure involved in this compound plays a key role in the research and development of antibacterial drugs. It can be used to adjust its structure to enhance antibacterial activity, expand the antibacterial spectrum or improve pharmacokinetic properties.
    In the field of pesticides, it can also act as an important intermediate. After further chemical transformation, pesticide products with insecticidal, bactericidal or herbicidal effects can be prepared. For example, some quinoline-containing pesticides have excellent inhibition and killing effects on specific pests or pathogens, which is helpful for the control of pests and diseases in agricultural production and the protection of crop yield and quality.
    In addition, in the field of organic synthetic chemistry, ethyl-7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxyquinoline-3-carboxylic acid esters are often used as starting materials or key intermediates to participate in the construction of complex organic molecules due to their unique chemical structure and reactivity. Through various organic reactions, such as nucleophilic substitution, electrophilic addition, etc., many organic compounds with novel structures can be derived, providing rich materials and diverse paths for the development of organic synthetic chemistry.
    What is the synthesis method of ethyl 7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylate?
    Synthesis of ethyl 7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxyquinoline-3-carboxylic acid esters, often follows the path of organic synthesis, involves multi-step reactions, and uses a well-designed process to achieve the formation of the target product.
    First, or start from a suitable quinoline derivative. Usually the corresponding haloquinoline is used as the raw material, and the cyanide group is introduced at the 8th position after cyanylation. This step of the reaction, mostly cyanide reagents, such as potassium cyanide, sodium cyanide, etc., under suitable reaction conditions, such as in an organic solvent, with a phase transfer catalyst, heating and stirring, so that the halogen atom and the cyano group are substituted to obtain 8-cyanoquinoline derivatives.
    Then, cyclopropyl is introduced at the 1 position. This can be achieved by nucleophilic substitution reaction. Cyclopropyl halide is used as a reagent, in the presence of a base, such as potassium carbonate, sodium carbonate, etc., in an organic solvent, reacts with 8-cyanoquinoline derivatives, and cyclopropyl negative ions attack quinoline 1 position as a nucleophilic reagent to form 1-cyclopropyl-8-cyanoquinoline derivatives.
    Furthermore, fluorine atoms are introduced at the 6th position. Most of the electrophilic fluorination reagents, such as Selectfluor, react with the above-mentioned derivatives in an appropriate reaction system to replace the hydrogen atoms in the corresponding positions with fluorine atoms to obtain 1-cyclopropyl-6-fluoro-8-cyanoquinoline derivatives.
    As for the introduction of the 7-position chlorine atom, a suitable chlorination reagent, such as phosphorus oxychloride, can be selected. Under suitable reaction conditions, react with the above product to replace the group at the corresponding position with a chlorine atom to obtain 7-chloro-1-cyclopropyl-6-fluoro-8-cyanoquinoline derivatives.
    Finally, the carboxylic acid ester part is synthesized. First, the 3-position carboxylation of the above quinoline derivatives can be achieved by reaction of organometallic reagents with carbon dioxide. Then, ethanol and carboxyl groups are esterified, and under acid catalysis, such as concentrated sulfuric acid, heating and refluxing, ethyl 7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxyquinoline-3-carboxylic acid ester is formed. Each step of the reaction requires fine regulation of the reaction conditions, including temperature, time, and the proportion of reactants, and various analytical methods, such as thin-layer chromatography, nuclear magnetic resonance, etc. are required to monitor the reaction process and product purity in order to achieve the ideal synthesis effect.
    What is the market outlook for Ethyl 7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylate?
    Guanfu "ethyl + 7 - chloro - 8 - cyano - 1 - cyclopropyl - 6 - fluoro - 4 - oxoquinoline - 3 - carboxylate", this is a professional term in the field of chemistry, Chinese or can be called "7 - chloro - 8 - cyano - 1 - cyclopropyl - 6 - fluoro - 4 - oxyquinoline - 3 - carboxylate ethyl ester". Its market prospect needs to be studied from multiple dimensions.
    In the field of medicine, such compounds may have antibacterial, antiviral and other pharmacological activities. At present, the problem of drug-resistant bacteria is serious, and the demand for new antibacterial drugs is eager. If this compound is proved to have high-efficiency antibacterial properties and is also effective against drug-resistant bacteria, it will have unlimited potential in the pharmaceutical market. Many pharmaceutical companies are making every effort to develop new antibacterial drugs. If this material can stand out, it will be able to occupy a place in the antibacterial drug market and bring considerable economic benefits.
    Second, the chemical industry may be used as a key intermediate for the synthesis of other complex compounds. The chemical industry is developing rapidly, and the demand for various intermediates is also increasing day by day. If the compound can use its own unique structure to help synthesize new materials with excellent performance, such as high-strength, high-stability polymers, etc., it will also be very popular in the chemical raw material market.
    However, its marketing activities are not smooth. R & D costs are a major challenge. From laboratory synthesis to large-scale production, huge sums of money need to be invested in process optimization, equipment purchase, etc. And safety assessment should not be underestimated. It is necessary to ensure that it has no adverse effects on human body and environment in pharmaceutical and chemical applications. Furthermore, the market competition is fierce, and similar or alternative products may have occupied a certain market share. If you want to stand out, you need to show unique advantages.
    In summary, the market prospect of "ethyl + 7 - chloro - 8 - cyano - 1 - cyclopropyl - 6 - fluoro - 4 - oxoquinoline - 3 - carboxylate" is broad, but it is also accompanied by many challenges. Practitioners need to consider carefully and move forward to have the opportunity to achieve great results in the market.
    What are the relevant safety precautions for ethyl 7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylate?
    Ethyl-7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxyquinoline-3-carboxylic acid ester, this is a rather complex organic compound. Regarding its safety precautions, let me elaborate.
    First, this substance is chemically active. When operating, be sure to wear suitable protective equipment, such as laboratory clothes, gloves and goggles. Because it may sensitize and irritate the skin, eyes and respiratory tract. If it comes into contact with the skin, rinse with plenty of water immediately; if it enters the eyes, rinse with running water quickly and seek medical attention in time.
    Second, due to its chemical properties, storage also requires special attention. It should be stored in a cool, dry and well-ventilated place, away from fire sources, heat sources and oxidants. Due to heat, fire or mixing with oxidants, dangerous chemical reactions may be caused, such as combustion or even explosion.
    Third, during use, be sure to operate in a fume hood to prevent inhalation of its volatile aerosols or dust. The volatile components of this compound may be harmful to human health, long-term inhalation or cause adverse consequences such as respiratory diseases.
    Fourth, disposal should not be sloppy. Relevant regulations and standards should be followed and should not be discarded at will. Due to its special chemical structure, improper disposal or pollution to the environment will endanger the ecological balance.
    When handling ethyl-7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxyquinoline-3-carboxylate, all aspects of caution are required to ensure personal safety and environmental safety.