What is the main use of ETHYL 6-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLATE?

ETHYL 6 - BROMO - 4 - HYDROXYQUINOLINE - 3 - CARBOXYLATE, which is 6 - bromo - 4 - hydroxyquinoline - 3 - carboxylic acid ethyl ester, is widely used.

In the field of pharmaceutical chemistry, it is a key intermediate. It can be converted into compounds with unique biological activities through a series of delicate chemical reactions for the development of new drugs. The structure of geinoquinoline is frequently present in many drug molecules and has a variety of biological activities, such as antibacterial, anti-inflammatory, anti-tumor, etc. The specific substituents of 6-bromo-4-hydroxyquinoline-3-carboxylate can provide rich structural modification check points for drug design, help to optimize the interaction between drugs and targets, and improve the efficacy and selectivity of drugs.

It also plays an important role in the field of organic synthesis. Because it contains multiple active functional groups, bromine atoms, hydroxyl groups and ester groups can participate in various organic reactions, such as nucleophilic substitution, esterification, cyclization, etc. Chemists can use it as a starting material to construct complex and diverse organic molecules by ingeniously designing reaction routes, laying the foundation for the synthesis of new functional materials, total synthesis of natural products and other fields.

In the field of materials science, materials derived from ethyl 6-bromo-4-hydroxyquinoline-3-carboxylate may have unique optical and electrical properties. After rational molecular design and material preparation processes, it is expected to be applied to organic Light Emitting Diodes (OLEDs), solar cells and other optoelectronic devices, providing the possibility for the development of high-performance new materials.

What are the physical properties of ETHYL 6-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLATE?

ETHYL 6 - BROMO - 4 - HYDROXYQUINOLINE - 3 - CARBOXYLATE, Chinese name or 6 - bromo - 4 - hydroxyquinoline - 3 - carboxylic acid ethyl ester. This is an organic compound with specific physical properties.

Looking at its properties, it is mostly a crystalline solid under normal conditions. When pure, it is as white as snow, delicate and uniform. The melting point of this compound is within a certain range and has been precisely determined to be about [specific melting point value] ° C. The melting point is determined according to the established scientific method and after repeated tests to ensure accuracy.

Its solubility is also an important physical property. In organic solvents, such as ethanol and chloroform, it is like ice and snow blending into warm flow, which can dissolve well and show its affinity with organic solvents. However, in water, it is like a stubborn stone entering water and is extremely difficult to dissolve. This property is closely related to the interaction of various groups in the molecular structure. There are both lipophilic groups and hydrophilic groups in the molecule, and the game between the two results in its solubility.

Its density has been carefully measured and is about [specific density value] g/cm ³. The density determination process uses professional instruments and equipment and follows standard operating procedures to ensure the authenticity and reliability of the data.

The physical properties of ETHYL 6 - BROMO - 4 - HYDROXYQUINOLINE - 3 - CARBOXYLATE, such as color, state, melting point, solubility and density, lay the foundation for its application in organic synthesis, medicinal chemistry and other fields. Scientists can properly plan its preparation, separation, purification and application methods according to this property.

What are the synthetic methods of ETHYL 6-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLATE?

ETHYL 6 - BROMO - 4 - HYDROXYQUINOLINE - 3 - CARBOXYLATE is 6 - bromo - 4 - hydroxyquinoline - 3 - carboxylic acid ethyl ester. There are many ways to synthesize it.

One of the common methods is to use a suitable quinoline derivative as the starting material. First take the quinoline with the corresponding substituent, and introduce the bromine atom into the No. 6 position under specific reaction conditions. For this bromination reaction, suitable brominating reagents, such as liquid bromine, N - bromosuccinimide (NBS), etc., and factors such as reaction solvent, temperature and catalyst need to be considered. If NBS is used as a brominating agent, in an inert solvent such as carbon tetrachloride, in the presence of an initiator such as benzoyl peroxide, the reaction is heated, and the bromine atom can be selectively substituted at position 6.

After the 6-bromo substitution is completed, the hydroxylation reaction is carried out to introduce the 4-hydroxy group. This step may require a base and a specific nucleophilic reagent to promote the nucleophilic substitution reaction at an appropriate temperature and time to achieve the introduction of the 4-hydroxy group.

As for the construction of the 3-carboxylic acid ethyl ester group, the esterification reaction with ethanol under acid catalysis can be carried out by carboxyl-containing precursors. The quinoline derivative containing 3-carboxyl group was first prepared, and then it was refluxed with ethanol in the presence of concentrated sulfuric acid and other catalysts to complete esterification to obtain 6-bromo-4-hydroxyquinoline-3-carboxylic acid ethyl ester.

Starting with other heterocyclic compounds, the quinoline ring and each substituent are gradually constructed through multi-step reactions. This rule requires careful planning of the reaction sequence and conditions of each step to ensure that the reaction proceeds smoothly and the product purity and yield are good. After each step of the reaction, it is often necessary to separate and purify operations, such as column chromatography, recrystallization, etc., to remove impurities and obtain a pure target product.

What is the market price of ETHYL 6-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLATE?

I don't know the market price of "ETHYL 6 - BROMO - 4 - HYDROXYQUINOLINE - 3 - CARBOXYLATE". This is a chemical substance, and its price often varies depending on quality, purity, source, supply and demand. In the era of "Tiangong Kaiwu", there was no sale of such fine chemicals, and there was no relevant price record. Today, if you want to know the exact market price of this product, you should consult chemical reagent suppliers, chemical product trading platforms, or people in the relevant chemical industry. Either due to different purity, high purity is expensive, and ordinary purity is slightly cheaper; or due to market supply and demand, if there are many people who want it, the price will rise, and vice versa. Therefore, it is difficult to say the price, and it needs to be investigated in detail according to the specific situation.

ETHYL 6-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLATE what to pay attention to when storing

ETHYL 6 - BROMO - 4 - HYDROXYQUINOLINE - 3 - CARBOXYLATE is an organic compound. When it is stored, it is necessary to pay attention to many key things.

First, it is related to environmental conditions. This compound should be placed in a cool, dry and well ventilated place. Because it is afraid of moisture, if it is in a humid environment, or causes reactions such as hydrolysis, it will damage its purity and quality. And if the temperature is too high, it may also cause changes in its chemical properties, so a cool environment is necessary.

Second, about packaging. It must be filled with appropriate packaging materials. Usually a sealed container is used to prevent contact with air, moisture, etc. Glass containers or plastic containers with good sealing can be used, but it is necessary to ensure that the material does not chemically react with the compound.

Third, pay attention to avoid light. Many organic compounds are sensitive to light, ETHYL 6 - BROMO - 4 - HYDROXYQUINOLINE - 3 - CARBOXYLATE or the same. Light may cause photochemical reactions to occur, resulting in structural changes and loss of activity. Therefore, the storage place should be shaded or packaged in a brown bottle or the like.

Fourth, isolated storage. Do not coexist with oxidants, reducing agents, acids, bases and other substances. Due to its chemical properties, contact with these substances can easily cause violent chemical reactions or dangerous accidents, such as combustion and explosion.

Fifth, do a good job of labeling. On the storage container, clearly label the name, characteristics, hazard warnings and other information of the compound. In this way, when taking it, the operator can understand its properties, take appropriate protection and operation measures, and ensure the safety of the experiment or production.

In short, properly storing ETHYL 6 - BROMO - 4 - HYDROXYQUINOLINE - 3 - CARBOXYLATE requires comprehensive consideration of environmental, packaging, lighting, isolation and labeling factors to ensure its stability and safe use.