What is the chemical structure of Quinoline-3-Carboxylate Ethyl 6,7-Difluoro-1-Methyl-4-Oxo-1H, 4H- (1,3) Thiazeto (3,2-a)?

< Br >
The name of this compound is complicated and difficult to explain its chemical structure, and the principles of organic chemistry should be followed.

The name of "Ethyl 6,7 - Difluoro - 1 - Methyl - 4 - Oxo - 1H, 4H - (1,3) Thiazeto (3,2 - a) Quinoline - 3 - Carboxylate", "Ethyl", ethyl is also, it can be known that the group containing ethyl in this compound is represented by "-COOCH 2O CH".

"6,7 - Difluoro" indicates that there is a fluorine atom substitution at the 6th and 7th positions of a specific parent nucleus, and the fluorine atom is denoted by "F". " 1 - Methyl "indicates that there is a methyl group at the 1st position, and the methyl group is" -CH <. "4 - Oxo" has a carbonyl group at the 4th position, and the carbonyl group is "C = O".

"1H, 4H - (1,3) Thiazeto (3,2 - a) Quinoline" indicates the structure of the parent nucleus, which is composed of a quinoline structure and a thiazolo ring. Quinoline has the structure of azanaphthalene, and the thiazolo ring is connected to it to form a unique fused ring system.

In summary, its chemical structure is roughly as follows: (1,3) thiazolo (3,2-a) quinoline as the parent nucleus, fluorine atoms at positions 6 and 7, methyl at position 1, carbonyl at position 4, and ethyl carboxylate at position 3. In this way, the approximate structure can be obtained by name.

What are the physical properties of Quinoline-3-Carboxylate Ethyl 6, 7-Difluoro-1-Methyl-4-Oxo-1H, 4H- (1,3) Thiazeto (3,2-a)

The physical properties of ethyl 6,7-difluoro-1-methyl-4-oxo-1H, 4H - (1,3) thiazolo (3,2-a) quinoline-3-carboxylate are of great value.

Looking at its morphology, at room temperature, it is mostly in the shape of a white-like to light yellow crystalline powder, which is delicate and uniform in quality. The particle size of the powder is moderate and the distribution is relatively uniform. Viewed under light, it is slightly shiny, as if the subtle stars are hidden in it.

When it comes to solubility, this compound exhibits unique solubility properties in organic solvents. In common organic solvents, such as methanol and ethanol, it can show a certain degree of dissolution. When it dissolves in ethanol, with a moderate increase in temperature, the dissolution rate accelerates, and the solution gradually clarifies and becomes transparent, as if it is hidden in the arms of the solvent. However, in water, its solubility is quite limited, and it is difficult to dissolve in water. It is like a foreign body that is incompatible with water, forming tiny particles suspended in water and difficult to fuse.

Another melting point, after rigorous measurement, the melting point of this substance is within a specific range, about between [X] ° C and [X] ° C. When the temperature slowly rises to the melting point range, its solid structure begins to gradually disintegrate, the orderly arrangement of crystal forms is broken, and the force between molecules is readjusted, transforming from solid to liquid. This process marks a key change in the state of matter.

Its density is also one of the important physical properties. After accurate measurement, it has a relatively certain value. This value has a non-negligible impact on its distribution and behavior in various systems, related to its proportion of space in the mixture and the way it interacts with other substances.

And its stability, under normal environmental conditions, can still maintain a relatively stable state, but if it encounters extreme environmental factors such as high temperature, high humidity or strong light, its structure may be damaged, causing chemical properties to change. Therefore, when storing and using, it is necessary to properly consider and control the external environmental conditions to ensure the stability of its physical properties and the integrity of its chemical structure.

What is the synthesis method of Ethyl 6, 7-Difluoro-1-Methyl-4-Oxo-1H, 4H- (1,3) Thiazeto (3,2-a) Quinoline-3-Carboxylate?

To prepare ethyl 6,7-difluoro-1-methyl-4-oxo-1H, 4H - (1,3) thiazolo (3,2-a) quinoline-3-carboxylic acid ester, the synthesis method is as follows.

First take a suitable starting material, such as a compound containing quinoline structure, carefully selected to ensure its purity and structure correctness. Place this raw material in the reaction kettle and add an appropriate amount of organic solvent to make the raw material fully disperse and facilitate the reaction. This organic solvent needs to be compatible with subsequent added reagents and has good adaptability to reaction conditions.

Then, a specific fluorinating reagent is added to the reaction system to introduce fluorine atoms at the 6,7-position. The choice of fluorinating reagents is crucial, and many factors such as reactivity, selectivity, and cost need to be considered. When adding fluorinated reagents, the speed and temperature of addition should be controlled to prevent the reaction from being too violent and causing side reactions. Under suitable temperature and stirring conditions, the fluorination reaction can be fully carried out. This process requires close monitoring of the reaction progress, and analytical methods such as thin-layer chromatography can be used.

After the fluorination reaction reaches the desired level, the next step is carried out to introduce 1-methyl. Select a suitable methylating reagent and add it to the reaction system in a certain proportion. It is also necessary to control the temperature, time, pH and other conditions of the reaction to ensure the smooth progress of the methylation reaction and precisely connect the methyl groups to the specified position.

Furthermore, construct a thiazolo ring structure. By adding reagents containing sulfur and nitrogen atoms, and adjusting the reaction environment, it is promoted to cyclize with fluorinated and methylated intermediates to generate the desired (1,3) thiazolo (3,2-a) quinoline structure. In this step, the control of the reaction conditions is particularly important, and subtle differences may lead to wide differences in the structure and yield of the cyclized products.

Finally, an esterification reaction is carried out to form ethyl 6,7-difluoro-1-methyl-4-oxo-1H, 4H - (1,3) thiazolo (3,2-a) quinoline-3-carboxylate. Ethanol and a suitable esterification catalyst are added, and the carboxylic acid and ethanol are esterified under heating and stirring conditions. After the reaction, the product is separated and purified, and various methods such as extraction and column chromatography can be used to obtain high-purity target products.

The above is the general method for synthesizing ethyl 6,7-difluoro-1-methyl-4-oxo-1H, 4H - (1,3) thiazolo (3,2-a) quinoline-3-carboxylic acid ester. In actual operation, it needs to be carefully adjusted and optimized according to the specific experimental conditions.

What are the application fields of Ethyl 6, 7-Difluoro-1-Methyl-4-Oxo-1H, 4H- (1,3) Thiazeto (3,2-a) Quinoline-3-Carboxylate

Ethyl 6,7-difluoro-1-methyl-4-oxo-1H, 4H - (1,3) thiazolo (3,2-a) quinoline-3-carboxylate, this compound has specific functions in the field of medicine and related fields.

In the field of antimicrobial drugs, it exhibits unique activity. Its structural properties give it the ability to inhibit and even kill specific bacteria. Certain Gram-positive and negative bacteria are affected by this compound due to the characteristics of cell membrane or cell wall structure and metabolic pathways. For example, it may be able to interfere with the normal operation of bacterial DNA gyrozyme, which plays an important role in key processes such as bacterial DNA replication and transcription. Once its function is blocked, it is difficult for bacteria to proliferate and survive normally, and then provide support for antibacterial treatment.

At the level of drug development, it can be used as a lead compound. Researchers can use this as a basis to optimize its structure by means of chemical modification. For example, by adjusting specific substituents, changing their electronic effects and spatial resistance, they hope to obtain new derivatives with better antibacterial activity and better pharmacokinetic properties. For example, changing the structure of the ester group may affect the lipid solubility of the compound, which in turn affects its absorption, distribution, metabolism and excretion in the body.

In addition, in the field of chemical synthesis research, it is also of great significance to explore the synthesis path of this compound. Developing more efficient, green and economical synthesis methods can reduce production costs and improve production efficiency. For example, exploring new catalysts or reaction conditions can make the synthesis steps more concise and reduce the occurrence of side reactions, which is of great significance for the large-scale preparation of this compound and subsequent application expansion.

Ethyl 6,7-Difluoro-1-Methyl-4-Oxo-1H, 4H- (1,3) Thiazeto (3,2-a) Quinoline-3-Carboxylate

Guanfu ethyl 6,7-difluoro-1-methyl-4-oxo-1H, 4H - (1,3) thiazolo (3,2-a) quinoline-3-carboxylic acid ester is quite promising in the market prospect.

This product is also a product of the field of medicinal chemistry. Since the general trend of today's pharmaceutical development, its prospects have begun to emerge, but there are many variables. At present, the pharmaceutical industry is tireless in the exploration of new compounds, and the pursuit of high-efficiency, low-toxicity and specific drugs is expected. If ethyl 6,7-difluoro-1-methyl-4-oxo-1H, 4H - (1,3) thiazolo (3,2-a) quinoline-3-carboxylate has unique pharmacological activities, such as antibacterial, anti-inflammatory, anti-tumor and other effects, and its safety and effectiveness have been experimentally verified, it will be able to compete for a place in the market.

Watching the market demand, there are many types of diseases and many patients. The research and development of new drugs, if they can hit the heart of the disease and solve the suffering of patients, the market demand will be considerable. If this compound is effective for a certain type of intractable disease or disease with high incidence, pharmaceutical companies must compete to develop and produce it to meet the needs of the market, and the future should be bright.

However, the challenges it faces must not be ignored. The road to drug development is arduous and long, and it needs to go through many experiments, from cell experiments to animal experiments to clinical trials, and many barriers, all of which need to be strictly verified. And there are many competing products of the same kind. If they do not have unique advantages in pharmacological properties and production costs, it may be difficult to stand out.

Overall, the market prospect of ethyl 6,7-difluoro-1-methyl-4-oxo-1H, 4H - (1,3) thiazolo (3,2-a) quinoline-3-carboxylic acid esters, such as seeing flowers in the fog, although there is a bright omen, it needs to be tempered by research and development and tested by the market before it can be understood.