What are the main uses of Ethyl 4-chloro-6-methoxyquinoline-3-carboxylate?

Ethyl 4-chloro-6-methoxyquinoline-3-carboxylic acid ester is a class of organic compounds. It has a wide range of uses and is often a key intermediate in the creation of new drugs in the field of medicinal chemistry. Due to its special chemical structure, compounds with different biological activities can be derived from various chemical reactions, making great contributions to the treatment of many diseases.

In the field of materials science, this compound may also have unique applications. Due to its stable structure and specific chemical properties, it may participate in the material synthesis process, endowing materials with special properties such as optics and electricity, and then be used in frontier fields such as optoelectronic devices and sensors.

Furthermore, in organic synthetic chemistry, ethyl 4-chloro-6-methoxyquinoline-3-carboxylic acid ester is an important starting material, which can be used to construct complex and diverse organic molecular structures through ingenious synthesis strategies, which can help the further development of organic synthetic chemistry and explore the synthesis path of novel compounds.

What are the synthetic methods of Ethyl 4-chloro-6-methoxyquinoline-3-carboxylate?

There are several common methods for the synthesis of ethyl 4-chloro-6-methoxyquinoline-3-carboxylic acid esters.

First, it can be obtained by the esterification reaction of the corresponding quinoline carboxylic acid and ethanol under the catalysis of acid. First take an appropriate amount of 4-chloro-6-methoxyquinoline-3-carboxylic acid and place it in the reaction vessel, add excess ethanol, because the esterification reaction is reversible, excess ethanol can promote the balance to move in the direction of ester formation. Adding an appropriate amount of concentrated sulfuric acid as a catalyst can enhance the electrophilicity of the carbonyl carboxylic acid, which is conducive to the nucleophilic attack of ethanol. The reaction process needs to be heated and stirred. Heating can speed up the reaction rate, and stirring can make the reactants fully contact. The temperature should be controlled in a moderate range. If it is too high, it may cause side reactions, and if it is too low, the reaction rate will be too slow. After the reaction is completed, the product is purified by neutralization, liquid separation, distillation, etc.

Second, halogenated quinoline is used as the starting material. First, the halogenated quinoline is reacted with a methoxylating agent to introduce a methoxy group. For example, an appropriate base is used as the acid binding agent, and a methoxylating agent such as sodium methoxide is reacted in a suitable solvent. After the methoxy group is successfully introduced, other check points on the quinoline ring are modified, such as the introduction of carboxyl eth It can be achieved by a coupling reaction with the corresponding halogenated carboxylic acid ester under the action of a metal catalyst. In this process, the choice of metal catalyst is crucial, and its activity and selectivity will affect the yield and purity of the reaction. After the reaction is completed, a series of post-processing steps, such as extraction, column chromatography, etc., are used to obtain pure ethyl 4-chloro-6-methoxyquinoline-3-carboxylic acid ester.

Third, a cyclization reaction strategy is adopted. The cyclization reaction is carried out under acidic or basic conditions with aniline derivatives containing appropriate substituents and β-ketoic acid esters as raw materials. Under acidic conditions, the nucleophilic addition of amino groups to the carbonyl group of β-ketoate can be promoted, and then dehydrated and cyclized to form a quinoline ring system. Under basic conditions, the reaction mechanism may be different, but it can also promote the cyclization reaction. During the reaction process, it is necessary to strictly control the reaction conditions, such as the ratio of reactants, reaction temperature, reaction time, etc., to ensure the formation of the target product. After the reaction is completed, the desired ethyl 4-chloro-6-methoxyquinoline-3-carboxylic acid ester is obtained by separation and purification.

What are the physical properties of Ethyl 4-chloro-6-methoxyquinoline-3-carboxylate?

Ethyl 4-chloro-6-methoxyquinoline-3-carboxylate is an organic compound. Its physical properties are of great importance and are relevant to many chemical applications.

This compound is at room temperature, or in the form of a solid state, with a specific melting point. The melting point is the temperature at which the substance changes from solid to liquid. Accurate determination of the melting point can help to identify its purity. If the purity is high, the melting point range is narrow; if the purity is low, the melting point range is wide and the melting point may be offset.

Looking at its appearance, or white or off-white crystalline powder, this morphological characteristic is easy to identify and handle in actual operation. The particle size of the powder is also affected, and the particle size is fine, and its solubility and reactivity may be different. < Br >
When it comes to solubility, this compound has good solubility in organic solvents, such as ethanol, acetone, dichloromethane, etc. The polarity, molecular structure and other factors of organic solvents interact with the compound, resulting in different degrees of solubility. In polar organic solvents, due to inter-molecular hydrogen bonds, dipole-dipole interactions, etc., it may be more soluble; in non-polar organic solvents, the solubility may be inferior.

Furthermore, its density is also an important physical property. Density represents the mass per unit volume, which is of great significance for chemical production, storage and transportation. Knowing the density can accurately calculate the loading amount in a specific container to ensure the safety and efficiency of operation.

Ethyl 4 - chloro - 6 - methoxyquinoline - 3 - carboxylate's physical properties are of critical value in chemical research and industrial production, helping researchers and producers better control their properties and behavior.

What are the chemical properties of Ethyl 4-chloro-6-methoxyquinoline-3-carboxylate?

Ethyl 4-chloro-6-methoxyquinoline-3-carboxylate is an organic compound with specific chemical properties. Its structure contains a quinoline ring, with a chlorine atom at the 4th position of the quinoline ring, a methoxy group at the 6th position, and a carboxyl group connected to an ethyl ester group at the 3rd position.

This compound has a certain nucleophilic substitution activity because it contains chlorine atoms. The chlorine atom can be replaced by a variety of nucleophilic reagents, such as alkoxides, amines, etc., whereby derivatives with diverse structures can be synthesized. For example, when reacting with alkoxides, the chlorine atom can be replaced by an alkoxy group to achieve molecular structure modification, which is of great significance in the field of organic synthesis. The methoxy group is the power supply group, which has an effect on the density distribution of the quinoline ring electron cloud, enhances the density of the ring electron cloud, changes the activity of the electrophilic substitution reaction on the ring, and the steric hindrance of the methoxy group also plays a role in the reaction selectivity.

Its ethyl ester part can undergo hydrolysis reaction under basic or acidic conditions. The corresponding carboxylic acid can be obtained by alkaline hydrolysis, and the free carboxylic acid can be obtained by acidification treatment; the acidic hydrolysis directly generates carboxylic acid and ethanol. This hydrolysis reaction is quite commonly used in the preparation of related carboxylic acid derivatives.

In addition, due to the existence of conjugated systems, this compound has certain photophysical properties, or can exhibit fluorescent properties, and may have potential application value in fluorescent materials and other fields. It has good solubility in organic solvents, which is conducive to various chemical reactions in solution systems and facilitates synthesis and research.

What is the price range of Ethyl 4-chloro-6-methoxyquinoline-3-carboxylate in the market?

I don't know what the price range of "Ethyl 4 - chloro - 6 - methoxyquinoline - 3 - carboxylate" is in the market. The price of this compound may fluctuate greatly due to factors such as purity, source, and market supply and demand.

Looking at the example of "Tiangong Kaiwu", the price of various things at that time was also affected by the origin, season, and process difficulties. Such as the genus of smelting, the materials used are different, the casting skills are different, and the prices are different. Today's "Ethyl 4 - chloro - 6 - methoxyquinoline - 3 - carboxylate", if it is high purity and used in special scientific research fields, the price will be high; if it is only ordinary industrial grade, the price may be slightly lower.

However, I have not personally involved in the trading market of this compound, so it is difficult to determine its price range. Or you need to consult chemical product distributors, scientific research material suppliers, or professional chemical product price information platforms to get a more accurate price.