ETHYL 4-CHLORO-6,8-DIFLUOROQUINOLINE-3-CARBOXYLATE

ETHYL 4 - CHLORO - 6,8 - DIFLUOROQUINOLINE - 3 - CARBOXYLATE, that is, 4 - chloro - 6,8 - difluoroquinoline - ethyl 3 - carboxylate, is widely used.
In the field of medicinal chemistry, it is often a key intermediate for the synthesis of many specific drugs. Quinoline compounds have various biological activities, such as antibacterial, anti-inflammatory, anti-tumor, etc. By ingenious modification and derivatization of the structure of this compound, new drugs with good efficacy and strong specificity can be created. Taking antimicrobial drugs as an example, after fine modification of their structures, drugs with high inhibitory activity against specific bacteria may be obtained, which can effectively deal with stubborn infectious diseases.
In the field of pesticide chemistry, it also plays an important role. Quinoline derivatives may have the functions of insecticide, herbicide, and sterilization. Using 4-chloro-6,8-difluoroquinoline-3-carboxylic acid ethyl ester as a basic raw material, through a series of chemical transformations, it may be possible to prepare environmentally friendly, efficient and low-toxicity pesticide products. For example, the development of insecticides targeting specific pests can precisely combat pests while reducing the harm to the environment and non-target organisms.
In the field of organic synthetic chemistry, due to its unique structure and reactivity, it is often used as a key building block for the construction of complex organic molecules. With its quinoline ring and functional groups such as ester groups and halogen atoms, complex organic compounds with specific structures and functions can be constructed through various organic reactions such as nucleophilic substitution and coupling, providing an important material basis for the creation of new materials and functional molecules.

ETHYL 4 - CHLORO - 6,8 - DIFLUOROQUINOLINE - 3 - CARBOXYLATE is an organic compound, the Chinese name is 4 - chloro - 6,8 - difluoroquinoline - 3 - carboxylic acid ethyl ester. Its physical properties are very important, and it is of great significance for chemical research and related industrial applications.
Looking at its appearance, under normal temperature and pressure, this compound is often in a colorless to light yellow liquid state, with uniform and clear texture and no obvious impurities. This appearance characteristic is convenient for intuitive identification and preliminary judgment of its quality in actual operation.
The boiling point is about a specific temperature range, because the exact value will vary slightly according to the experimental conditions. In general, its boiling point is at a relatively high temperature, indicating that the intermolecular force is strong, and high energy is required to convert it from liquid to gaseous. This property is crucial in the process of separation and purification, for example, it can be separated from other substances by distillation according to the difference in boiling point.
In terms of melting point, the compound has a specific melting point, and when the solid and liquid state transition, the phase change occurs at a specific temperature range. The accurate determination of the melting point helps to determine the purity of the compound. The melting point of the pure product is more sensitive. If it contains impurities, the melting point will be reduced and the melting range will be wider.
Solubility is also a key physical property. It exhibits good solubility in common organic solvents such as ethanol, acetone, and dichloromethane, and is mutually soluble with these solvents in a certain proportion. However, the solubility in water is very small. This solubility characteristic determines the choice of solvent in the chemical reaction. Organic solvents can promote the reaction because they can fully contact the reactants and increase the reaction rate and yield.
The density is a specific value. Compared with water, its density is different, which needs to be taken into account when operations such as liquid-liquid separation are involved. Density differences can be used to achieve separation from the aqueous phase or other liquids of different densities by means of liquid separation.
In addition, the compound may have a certain odor. Although it is not pungent and unpleasant, it is also necessary to pay attention to ventilation during operation to prevent discomfort to the human body. Its physical properties are stable, and under general environmental conditions, it will not spontaneously change significantly in a short period of time. In case of extreme conditions such as high temperature and open flame, it may cause chemical reactions, so it is necessary to follow safety regulations when storing and using.

The preparation of ETHYL 4-CHLORO-6,8-DIFLUOROQUINOLINE-3-CARBOXYLATE (4-chloro-6,8-difluoroquinoline-3-carboxylate ethyl ester) requires a multi-step reaction.
The first step, or by suitable starting materials, such as aromatic hydrocarbon derivatives containing fluorine and chlorine, can be halogenated to precisely introduce chlorine atoms and fluorine atoms at specific positions. This process requires the selection of appropriate halogenation reagents and reaction conditions. Halogenation reagents such as chlorine gas, hydrogen chloride, fluorination reagents, etc., are selected according to the activity and positioning requirements of the reaction substrate. The reaction conditions also need to be carefully regulated, such as temperature, pressure, catalyst, etc.
The second step is to form a quinoline ring structure through cyclization. This step often requires the help of suitable catalysts and reaction solvents to promote intramolecular rearrangement and cyclization. The catalyst may be an acid, base or metal catalyst, and the solvent needs to be able to dissolve the substrate without adverse effects on the reaction. For example, organic solvents such as dichloromethane, N, N-dimethylformamide are selected.
Next, a carboxyl group is introduced at the 3-position of the quinoline ring, which can be achieved by a specific carboxylation reaction, using reagents such as carbon dioxide or other carboxylation reagents.
Last step, the carboxyl group is converted to ethyl ester. Ethanol and suitable esterification reagents can be used to carry out the esterification reaction under the action of acid catalysis or condensation agent, such as concentrated sulfuric acid, dicyclohexylcarbodiimide (DCC), etc. as catalysts or condensation agents to complete the synthesis of 4-chloro-6,8-difluoroquinoline-3-carboxylic acid ethyl ester. Each step of the reaction requires careful monitoring and purification to obtain a high-purity target product.

I look at your question and ask "ETHYL 4 - CHLORO - 6,8 - DIFLUOROQUINOLINE - 3 - CARBOXYLATE" about the market price range. However, this cannot be easily determined.
The price of this compound is affected by many factors. First, the difficulty of its preparation is also. If the synthesis requires complicated steps, special raw materials or harsh reaction conditions, the cost will be high and the price will be expensive. Second, the amount of market demand is also the key. If there is a lot of demand, the supply will exceed the demand, and the price will rise; if the demand is small and the supply exceeds the demand, the price will be depressed. Third, the production scale is different. In large-scale production, the unit cost may decrease or the price may decrease due to the scale effect; in small-scale production, the cost is high and the price is high.
Looking at past market conditions, the price of similar compounds varies greatly. Simple and common, the price may be relatively simple; complex and rare, the price is high. And "ETHYL 4 - CHLORO - 6,8 - DIFLUOROQUINOLINE - 3 - CARBOXYLATE", without detailed market survey data, it is difficult to determine the price range.
Generally speaking, in the fine chemical raw material market, such quinoline derivatives containing special substituents, if the demand is average and the synthesis is not extremely difficult, the price per gram may be between tens and hundreds of yuan; if the synthesis is extremely difficult or the demand is strong, the price per gram may exceed 1,000 yuan, or even higher. However, this is only speculation, and the real price needs to be checked in detail on the chemical product trading platform, consult relevant suppliers or industry insiders to obtain the exact number.

ETHYL 4 - CHLORO - 6,8 - DIFLUOROQUINOLINE - 3 - CARBOXYLATE, Chinese name or 4 - chloro - 6,8 - difluoroquinoline - 3 - carboxylic acid ethyl ester. The manufacturer of this compound, the skilled craftsmen in the world have their own skills. In the chemical industry, many manufacturers are involved in the preparation of such fine chemicals.
In the land of Huaxia, there are many manufacturers specializing in organic synthesis. They have exquisite skills and excellent production equipment. For example, some chemical enterprises in developed coastal areas can produce this compound stably with advanced technology and management. They invest a lot in research and development, which can continuously optimize the production process and improve product quality.
There are also many such manufacturers overseas. In Europe and the United States, the chemical industry has a long history, and some established companies have accumulated deep experience in the production of this compound. They pay attention to environmental protection and sustainable development, follow strict standards in the production process, and their products are of high quality, which is quite reputable in the international market.
There are also some emerging chemical companies, although they have been established for a short time, but they are determined to forge ahead. With innovative technology and efficient operation, they are also among the ranks of this compound production. With their flexible market strategy, they can quickly respond to customer needs and provide a diverse product selection for the market.
In short, the manufacturers that produce ETHYL 4 - CHLORO - 6,8 - DIFLUOROQUINOLINE - 3 - CARBOXYLATE, whether large or small, medium or foreign, all have their own advantages, occupying a place in the chemical market, promoting the continuous development of the production and application of such compounds.