What is the chemical structure of ethyl (2R) -2-ethoxyquinoline-1 (2H) -carboxylate

Alas! This is an organic compound called ethyl (2R) -2-ethoxyquinoline-1 (2H) -formate. Its chemical structure is quite complex, let me elaborate.

This compound is based on the quinoline ring. The quinoline ring is a heterocyclic aromatic hydrocarbon containing nitrogen. It has a conjugated system and has unique properties. In the 1 (2H) position of the quinoline ring, it is connected to a formate ester group. In this group, the carbonyl carbon is connected with oxygen by a double bond, and it forms an ester bond with an oxygen atom. The oxygen atom is complex with ethyl, which is a straight-chain alkyl group and has certain hydrophobicity. < Br >
Furthermore, at the second position of the quinoline ring, it is connected to an ethoxy group, and this position is chiral, and the configuration is (2R). Chiral, like human hands, mirror images and cannot be overlapped, which have a significant impact on the physical, chemical and biological activities of the compound.

For ethoxy, the oxygen atom is connected to ethyl, which is the electron cloud density of the quinoline ring, which can affect its reactivity.

In summary, the chemical structure of ethyl (2R) -2-ethoxyquinoline-1 (2H) -formate is composed of quinoline ring, formate group, ethoxy group and other parts. The interaction of each part endows this compound with unique chemical properties.

What are the main uses of ethyl (2R) -2-ethoxyquinoline-1 (2H) -carboxylate

(2R) -2-ethoxyquinoline-1 (2H) -ethyl carboxylate, which is widely used in the field of pharmaceutical and chemical synthesis.

In the way of pharmaceutical creation, it can be used as a key intermediate to help build a complex and delicate drug molecular structure. For example, when developing specific antimalarial drugs, with its unique chemical structure, it can precisely fit with specific targets in the Plasmodium, by blocking the metabolic pathway or physiological activities of the Plasmodium to achieve antimalarial effect. For example, in the synthesis of some antimicrobial drugs, it can be used as a starting material. After multiple steps of delicate reactions, compounds with excellent antimicrobial activity can be derived to deal with difficult bacterial infections. < Br >
In chemical synthesis, it can be used to prepare functional materials with unique characteristics. In the field of polymer material synthesis, (2R) -2 -ethoxyquinoline-1 (2H) -ethyl carboxylate can be introduced as a monomer or modifier. If it is introduced into the synthesis process of polyester materials, the resulting polyester materials may exhibit better thermal stability and mechanical properties, broadening the application of polyester materials in high temperature and high stress environments. In the coating industry, it can participate in the synthesis of coating resins, endowing coatings with excellent characteristics such as corrosion resistance and weather resistance, so that coatings can maintain good decorative and protective functions in harsh environments for a long time.

In addition, in the basic research of organic synthetic chemistry, (2R) -2 -ethoxyquinoline-1 (2H) -ethyl carboxylate is often used as a model compound, which helps researchers to deeply explore the mechanism of organic reactions. By studying the various reactions it participates in, such as nucleophilic substitution, electrophilic addition, etc., the influence of reaction conditions and reactant structure on the reaction process and product selectivity can be clarified, which solidifies the theoretical foundation for the development of organic synthesis methodology, and then promotes organic synthesis chemistry to continuously move towards new frontiers and achieve more efficient, green and precise synthesis paths.

What are the synthesis methods of ethyl (2R) -2-ethoxyquinoline-1 (2H) -carboxylate

The method for the synthesis of (2R) -2-ethoxyquinoline-1 (2H) -ethyl carboxylate is quite complicated and delicate.

First, quinoline is used as a group, and the activity of quinoline is modified by appropriate protective groups. Here, suitable protective groups, such as benzyl, can be selected to ensure the regioselectivity of subsequent reactions.

Then, ethoxy is introduced. Appropriate ethoxylating reagents, such as bromoethane, can be selected by means of nucleophilic substitution to cooperate with bases. In an appropriate solvent, such as dimethylformamide (DMF), the temperature-controlled reaction allows the ethoxy group to be successfully integrated into the specific position of quinoline. This process requires careful monitoring of the reaction process to maintain the efficiency and accuracy of ethoxylation.

After the ethoxy group is successfully introduced, the ethesterification reaction of the carboxyl group is carried out. The acid chloride method can be used to first convert the carboxyl group-containing precursor into an acid chloride, which is treated with a reagent such as sulfinyl chloride. Then it reacts with ethanol under the catalysis of a base to form an ethyl ester structure. The choice of base is crucial, such as triethylamine, which not only promotes the reaction, but also does not unduly affect other parts of the molecule.

Or direct esterification method can be used, using carboxyl groups and ethanol, under the catalysis of strong acids, such as p-toluenesulfonic acid, in the presence of an appropriate water-carrying agent, azeotropic water removal is used to promote the esterification The whole process of

synthesis requires fine control of reaction conditions, such as temperature, time, and the equivalent of reagents. And after each step of reaction, separation and purification techniques, such as column chromatography, recrystallization, etc. are required to obtain high-purity target products. In this way, (2R) -2-ethoxyquinoline-1 (2H) -carboxylic acid ethyl ester can be successfully synthesized.

What are the physical properties of ethyl (2R) -2-ethoxyquinoline-1 (2H) -carboxylate

(2R) -2 -ethoxyquinoline-1 (2H) -ethyl carboxylate, this is an organic compound. Looking at its physical properties, the first is its appearance. Under normal conditions, or a transparent liquid that is colorless to light yellow. When pure, it is clear and translucent, and there are no visible impurities. This is because of the arrangement and combination of atoms in the molecular structure, which makes it appear in this phase at room temperature and pressure.

Second, the boiling point is about a specific temperature range. Due to the existence of a certain interaction force between molecules, such as van der Waals force, the external world needs to provide corresponding energy to overcome this force before it can be converted from liquid to gaseous. When the external temperature rises to the boiling point, the molecules obtain enough energy to get rid of each other and escape from the liquid surface.

Furthermore, the melting point is also in a certain temperature range. When the temperature drops to the melting point, the thermal motion of the molecules slows down, and the attractive forces between them promote their orderly arrangement to form a regular lattice structure, and the substance solidifies from liquid to solid.

In terms of solubility, in organic solvents, such as ethanol, ether, etc., it shows good solubility. Due to the principle of "similar phase dissolution", the molecular structure of the compound has similar polarity or intermolecular force type to the organic solvent molecules, and it is easy to penetrate and mix with each other. However, the solubility in water is poor, because the overall polarity of the molecule is relatively weak, and the force between the water molecules is difficult to overcome the strong hydrogen bond between the water molecules, so it is difficult to dissolve in water. < Br >
Density is also one of its important physical properties. At a specific temperature, there is a corresponding density value. This is related to the molecular mass and the degree of intermolecular packing compactness, reflecting the mass size of the substance per unit volume.

In addition, the refractive index also has a specific value. When light passes through the substance, it is refracted due to the influence of the substance on the speed of light propagation. The refractive index can characterize this property and is related to the molecular structure and the degree of molecular arrangement. These are the main physical properties of (2R) -2 -ethoxyquinoline-1 (2H) -ethyl carboxylate.

In which fields is ethyl (2R) -2-ethoxyquinoline-1 (2H) -carboxylate used?

(2R) - 2-ethoxyquinoline-1 (2H) -ethyl carboxylate, which is useful in many fields. In medicine, it may be a key raw material for the creation of new drugs. Due to its unique chemical structure, it can be used to build specific drug molecules, which are expected to be used to treat specific diseases and help medicine save people.

In the field of organic synthesis, it can be called an exquisite building block. With its characteristics, through ingenious reactions, we can build complex and delicate organic molecular structures, enrich the types of organic compounds, and promote the refinement of organic synthesis techniques.

In the field of materials science, it also has potential. Or it can be specially treated to give materials different properties, such as improving the stability of materials, optical properties, etc., so that materials can find a place in the fields of electronics and optics, and contribute to material innovation.

Furthermore, in the process of scientific research and exploration, it is an important research object. Scientists can use the study of its reaction characteristics, physical and chemical properties, insight into the mystery of chemical changes, expand the boundaries of chemical knowledge, and lay the foundation for scientific progress. It is of great significance to the development of various disciplines.