ethyl (1s)-1-phenyl-3,4-dihydro-1h-isoquinoline-2-carboxylate

This is a problem related to the chemical structure of " (1S) -1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid ethyl ester". This compound is derived from the isoquinoline parent nucleus, and its isoquinoline ring has a saturated structure formed by double-bond hydrogenation at the 3,4 position.
Looking at its structure, the 1-position connecting phenyl group, the introduction of this phenyl group, because the benzene ring has a conjugated system, can significantly affect the electron cloud distribution and spatial configuration of the molecule, and has a role in its physical and chemical properties such as melting point, boiling point, solubility, etc. In terms of biological activity, the benzene ring is often a key structural part of the interaction with biological targets, or can enhance the binding force between molecules and receptors. The
2 position is the carboxylic acid ethyl ester group obtained by esterification of the carboxyl group with ethanol. The existence of the ester group endows the molecule with certain lipophilic properties, which affects its absorption, distribution and metabolism in vivo. In chemical reactions, the ester group can undergo many reactions such as hydrolysis and alcoholysis, which is an important activity check point in organic synthesis. Furthermore, the S configuration of its 1 position determines the spatial three-dimensional structure of the molecule. The chiral structure is of great significance in pharmaceutical chemistry. Different enantiomers often have significant differences in biological activity and toxicity. This specific configuration may make the compound exhibit a unique interaction mode and biological activity when interacting with chiral biological targets.
In conclusion, the chemical structure of " (1S) -1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid ethyl ester" is synergistic with each other, which jointly determines its physicochemical properties and biological activities, and has important research value in the fields of organic synthesis and drug development.

(1S) -1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid ethyl ester, this compound has a wide range of uses. In the field of medicinal chemistry, it is an important intermediate and participates in the synthesis of many drugs. Due to the unique biological activity of isoquinoline structure, many drugs synthesized on this basis have shown potential efficacy in the treatment of neurological diseases such as Parkinson's disease and Alzheimer's disease. Some drugs can regulate neurotransmitter transmission, protect nerve cells, and bring new hope for the treatment of related diseases.
In the field of organic synthetic chemistry, it is a key building block. With its structural properties, it can build complex organic molecular structures through various chemical reactions. The ester group and phenyl group contained in it can be used to expand the molecular skeleton by means of esterification, nucleophilic substitution, coupling and other reactions, and lay the foundation for the synthesis of organic materials with specific functions. For example, in the research and development of new optoelectronic materials, materials with special optical and electrical properties have been prepared by using this as the starting material and ingeniously designing the synthesis route, which are used in organic Light Emitting Diode, solar cells and other fields.
In the field of total synthesis of natural products, some natural products with complex structures often involve (1S) -1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid ethyl ester. Through the reasonable modification and transformation of the compound, the core skeleton of the natural product can be gradually constructed, and then the total synthesis can be completed, which will help the in-depth study of the biological activity and pharmacological effects of the natural product.

The preparation of (1S) -1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid ethyl ester requires several steps. In the first step, phenethylamine and ethyl acrylate are used as starting materials, and under appropriate reaction conditions, the Michael addition reaction occurs between the two. This reaction requires the addition of the double bond between the amino group of phenethylamine and ethyl acrylate at a suitable temperature or in an organic solvent, accompanied by a catalyst, to form a specific intermediate.
Next, the resulting intermediate is subjected to an intramolecular cyclization reaction. This process may require specific reaction conditions, such as heating under the action of acidic or basic catalysts, to promote the formation of intramolecular cyclization to form the basic skeleton of 1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate ethyl ester.
Furthermore, the resulting product needs to be chirally induced or split to obtain the target product of the (1S) configuration. A specific chiral configuration can be induced by a reaction involving a chiral catalyst; or a chiral resolution method, such as chiral column chromatography, can be used to separate the (1S) isomer from the racemic mixture due to the difference in the interaction force of the target product enantiomer and the chiral stationary phase.
The whole preparation process is crucial to control the reaction conditions. Temperature, reaction time, proportion of reactants, type and dosage of catalysts all affect the reaction process and product purity and yield. After each step of the reaction, the product needs to be properly separated and purified to ensure the smooth progress of the subsequent reaction. In this way, after careful operation in multiple steps, (1S) -1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid ethyl ester can be obtained.

(1S) -1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid ethyl ester, this is an organic compound. Its physical properties are unique, let me explain in detail.
Looking at its properties, under normal temperature and pressure, this substance is mostly in a solid state, or in a crystalline state, and its color is often white to quasi-white, like the first snow in winter, pure and flawless.
When it comes to melting point, this compound has a specific melting point value, but it fluctuates slightly due to differences in preparation and purity. Roughly in a certain temperature range, when heated to this temperature range, the substance slowly converts from solid state to liquid state. This is the phase change point from solid to liquid, like ice melting in warm sun.
The boiling point is also an important physical property of the compound. Under certain pressure conditions, when the compound is heated to the boiling point, it can be seen that it boils, and the liquid quickly changes to a gaseous state, which is the key temperature for its gas-liquid conversion. However, the boiling point also varies with pressure, just as the boiling point of water varies between mountains and plains.
In terms of solubility, (1S) -1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid ethyl ester exhibits different solubility properties in organic solvents. Common organic solvents such as ethanol and chloroform have good solubility to them, and can dissolve with them to form a uniform solution, just like fish water. In water, its solubility is poor, and it mostly exists in a suspended or insoluble state, just like oil floating on the water surface.
In addition, density is also the main point to consider its physical properties. The substance has a specific density value, which reflects its mass per unit volume. In related research and applications, this characteristic cannot be ignored.

Ethyl (1S) -1-phenyl-3, 4-dihydro-1H-isoquinoline-2-carboxylate is an organic compound. This compound has many chemical properties.
It contains an ester group, and the ester group is active and can undergo hydrolysis. In acidic media, hydrolysis generates (1S) -1-phenyl-3, 4-dihydro-1H-isoquinoline-2-carboxylic acid and ethanol; under basic conditions, hydrolysis is more thorough, resulting in corresponding carboxylic salts and ethanol.
Furthermore, the compound contains 1-phenyl-3, 4-dihydro-1H-isoquinoline structure, and the benzene ring in this structure can undergo electrophilic substitution reaction. Due to the high electron cloud density of the benzene ring, it is vulnerable to electrophilic reagents. If under appropriate conditions, halogenation reactions can occur, introducing halogen atoms; nitrification reactions, sulfonation reactions, etc.
At the same time, there are double bonds in the 3,4-dihydro-1H-isoquinoline part. Although it is not a typical olefin double bond, it still has a certain degree of unsaturation. Under specific conditions, it can undergo addition reaction with some reagents, such as with hydrogen under the action of a suitable catalyst, the double bond can be hydrogenated and reduced to form saturated 1-phenyl-1,2,3,4-tetrahydro-1H-isoquinoline derivatives.
In addition, the chiral center (1S configuration) in this compound determines its optical activity, which is of great significance in the fields of asymmetric synthesis and medicinal chemistry. Different chiral configurations of enantiomers may have significant differences in biological activity and pharmacological effects. < Br >
This compound is rich in chemical properties and has potential applications in many fields such as organic synthesis and drug development.