Ethyl 1-chloro-4-hydroxy-7-phenoxyisoquinoline-3-carboxylate

Ethyl 1-chloro-4-hydroxy-7-phenoxyisoquinoline-3-carboxylate (ethyl 1-chloro-4-hydroxy-7-phenoxyisoquinoline-3-carboxylate) It is difficult to have an exact correspondence at the time of "Tiangong Kaiju". "Tiangong Kaiju" was written in Chongzhen ten years in the Ming Dynasty, when the chemical synthesis was still in its infancy, and the synthesis and application of such complex organic compounds is the result of the development of modern chemistry.
If it is strongly attached, it may be slightly speculated from the carboxylic acid ethyl ester part of its structure. In ancient times, although there was no such specific compound, esters may have similar applications in some aspects. For example, in the processing of grease, grease is a high-grade fatty acid glyceride, which belongs to the same ester as ethyl carboxylate. Grease can be used for lighting, lubrication, soap making, etc. In lighting, animal grease or vegetable oil was often used as fuel in lamps to burn for lighting in ancient times. If this compound existed at that time, its flammability may be considered for similar lighting purposes, but its complex structure such as chlorine and phenoxy groups may affect its combustion characteristics and practical value.
In the field of lubrication, natural oils can be used to reduce friction between mechanical parts. If this compound has suitable physical properties, such as low viscosity, good adhesion, etc., or can be tried as a lubricant, its complex structure may lead to poor compatibility with traditional materials.
As for soap making, traditional soap making uses the reaction of grease and alkali to form soap. Although this compound is not a traditional oil, in theory, if its carboxylic acid ethyl ester part can be hydrolyzed under alkaline conditions to generate corresponding acid and ethanol, acid and alkali reaction, or can simulate the soap making process, but the properties of the product are different from those of traditional soap or larger. However, this is all speculation based on modern chemical knowledge of hypothetical situations, which is far from the real application in the era of "Tiangong Kaiwu".

To prepare ethyl 1-chloro-4-hydroxy-7-phenoxyisoquinoline-3-carboxylic acid ester, there are many ways to synthesize it. In general, it can be formed by several steps of reaction.
First, or start from the corresponding isoquinoline derivative. First, the isoquinoline ring is introduced into the chlorine atom at position 1 under suitable reaction conditions. This may be done by halogenating reagents, such as chlorine-containing reagents, at a specific temperature and in the presence of a catalyst.
Second, the hydroxyl group is introduced at position 4. This may be through a nucleophilic substitution reaction, with a suitable nucleophilic reagent, replacing the corresponding substituent to achieve the introduction of hydroxyl groups. This process requires fine regulation of the reaction conditions to ensure the selectivity of the reaction.
Furthermore, the phenoxy group is introduced at position 7. Or the phenoxy group can be connected to the isoquinoline ring through an arylation reaction. This may require the use of transition metal catalysts, such as palladium catalysts, to promote the reaction.
At the end, the structure of ethyl carboxylate is constructed at position 3. Or carboxylic acid derivatives, such as acyl chloride or acid anhydride, can be used to react with ethanol under the catalysis of a base to form the structure of ethyl carboxylate.
Each step of the reaction requires careful selection of reaction reagents, control of reaction temperature, reaction time and pH of the reaction system. After each step of the reaction, recrystallization, column chromatography and other methods may be required to purify the product, improve the purity of the product, and ensure the smooth synthesis and quality of the product. In this way, several steps can be followed in sequence to achieve the purpose of synthesizing ethyl 1-chloro-4-hydroxy-7-phenoxyisoquinoline-3-carboxylate.

Ethyl 1 - chloro - 4 - hydroxy - 7 - phenoxyisoquinoline - 3 - carboxylate is an organic compound. The physical properties of this compound allow me to tell you.
Looking at its properties, it may be a solid under normal conditions, because many organic compounds containing similar structures are in a solid state. Its color may be white to light yellow powdery material, because the presence of substituents such as phenoxy and chlorine atoms in this type of structure affects the absorption and reflection of light by molecules to a certain extent, resulting in this color range.
When it comes to melting point, due to the existence of various interactions in molecules, such as hydrogen bonds, van der Waals forces, etc., it is expected that its melting point is relatively high. The hydroxyl groups in the molecule can form intermolecular hydrogen bonds, enhance the intermolecular force, and increase the lattice energy, so the melting point rises. It is speculated that its melting point may be between 150 ° C and 250 ° C, but the exact value needs to be accurately determined experimentally.
As for solubility, the compound has a certain polarity because it contains polar carboxyl ethyl ester groups and hydroxyl groups, so it should have a certain solubility in polar organic solvents such as methanol, ethanol, acetone, etc. The presence of phenoxy groups makes it have a certain lipid solubility, and it may also have a certain degree of solubility in some non-polar solvents such as dichloromethane and chloroform. However, in water, because the molecule as a whole is not highly hydrophilic, the solubility may be limited.
In terms of density, its density may be slightly higher than that of water based on its molecular structure and the relative atomic mass of its constituent atoms. Due to the presence of chlorine atoms, benzene rings and other structural units in the molecule, the mass per unit volume is relatively large.
In summary, Ethyl 1-chloro-4-hydroxy-7-phenoxyisoquinoline-3-carboxylate has the above physical properties, but the actual properties still need to be based on the experimental data.

Ethyl 1 - chloro - 4 - hydroxy - 7 - phenoxyisoquinoline - 3 - carboxylate is an organic compound. Its chemical properties are quite unique, let me elaborate.
This compound contains chlorine atoms, and the properties of chlorine give it a certain activity. Chlorine atoms can be used as leaving groups in many chemical reactions, such as nucleophilic substitution reactions, which are easily replaced by nucleophiles. Its reactivity allows the compound to participate in a variety of organic synthesis pathways, providing the possibility to construct more complex organic molecular structures. The presence of
4 - hydroxyl groups also has a significant impact. The hydroxy group is hydrophilic, so that the compound can form hydrogen bonds with water molecules to a certain extent, which affects its solubility. And the hydroxyl group is also acidic. Although the acidity is weak, it can deprotonate when a suitable base exists, and then participate in various acid-base related reactions. Hydroxyl groups can also undergo esterification reactions to react with acids to form ester compounds. This reaction is often used in organic synthesis to modify molecular structures and change the properties of compounds.
7-phenoxy partially adds the aromaticity and hydrophobicity of the molecule. The conjugation system of phenoxy groups enhances the overall stability of the molecule, and at the same time affects the distribution of its electron cloud, which in turn affects the reactivity and physical properties of the compound. Aromatic rings can be used as an activity check point for electrophilic substitution reactions, introducing different substituents to enrich the structural diversity of compounds.
And ethyl ester-COOEt not only provides a certain steric barrier for molecules, but also can be hydrolyzed under basic or acidic conditions. Basic hydrolysis produces carboxylic salts and ethanol, and acidic hydrolysis produces carboxylic acids and ethanol. This hydrolysis reaction is of great significance in the fields of organic synthesis and drug metabolism.
Overall, Ethyl 1 - chloro - 4 - hydroxy - 7 - phenoxyisoquinoline - 3 - carboxylate exhibits diverse and unique chemical properties due to the interaction of different functional groups, which has potential application value in many fields such as organic synthesis and medicinal chemistry.

It is not an easy task to inquire about the market price of "Ethyl + 1 - chloro - 4 - hydroxy - 7 - phenoxyisoquinoline - 3 - carboxylate" today. To cover this or a rare chemical, its market price needs to be investigated in detail.
If in the world of "Tiangong Kaiwu", although there is no such fine chemical, it is also enlightening to look at the method of exploring it there. If you want to know the price of this product today, you should visit the chemical market and the genus of the pharmacy. Or ask the merchants who specialize in chemical materials, they may know the value of this product.
In today's world, information is accessible, and it can also be obtained on the online business platform. Observe the price quoted by various merchants, and observe the differences in their quality and measurement to analyze the level of their price. However, due to the special use and difficulty in preparation, the price of this product may fluctuate. Or due to changes in market supply and demand, the price is sometimes high, and sometimes the price is low.
If you want to get an accurate price, you should go to the place where chemical materials are collected and distributed in person, discuss it in detail with various merchants, and observe their goods in detail before you can know the exact price in the market. Although it is difficult to achieve it overnight, you may be able to obtain its approximate price by following this route.