What is the chemical structure of -Methyl-6-quinolineacetic acid ethyl ester?

What I am asking you is what is the chemical structure of "α-Methyl-6-quinolineacetic acid ethyl ester". This substance is also an organic compound. From its name and disassembly, "quinoline", quinoline is a nitrogen-containing heterocyclic aromatic hydrocarbon with the structure of benzopyridine. Its parent nucleus, quinoline, is connected to "quinolineacetic acid" at the sixth position, which is the structural part of quinoline acetic acid, meaning that the acetic acid group is connected to the quinoline at the sixth position. Furthermore, "α-Methyl" means that there is a methyl group at the α position, that is, there is a methyl substitution on the carbon atom directly connected to the carboxyl group. And "ethyl ester" indicates that this substance is an ethyl ester, that is, the carboxyl group undergoes esterification reaction with ethanol to form an ester group - COOCH ® CH 🥰. In summary, the chemical structure of "α-Methyl-6-quinolineacetic acid ethyl ester" is based on quinoline as the parent nucleus, and the sixth position is connected with an ethyl acetate group with α-methyl. This structure has specific physical and chemical properties due to the interaction between each atom and the group, and may be important in organic synthesis, medicinal chemistry and other fields.

What are the physical properties of α -Methyl-6-quinolineacetic acid ethyl ester?

α-methyl-6-quinoline ethyl acetate, this is an organic compound. Looking at its structure, it contains a fragment of quinoline ring and ethyl acetate, and this structure gives it unique physical properties.

Let's talk about the properties first. Usually α-methyl-6-quinoline ethyl acetate is a colorless to pale yellow liquid. When viewed in sunlight, it can be seen that it is clear and has a faint luster. If placed in a glass container and shaken lightly, it can feel that its fluidity is quite good. Because the intermolecular force is not strong, it is in a liquid state.

When it comes to boiling point, after many experiments, its boiling point is about a certain range. Due to the existence of van der Waals forces and weak hydrogen bonds between molecules, it is necessary to provide enough energy to overcome such forces in order to make the molecule break free from the liquid phase and convert to the gas phase.

Solubility is also an important property. Ethyl α-methyl-6-quinoline acetate is soluble in common organic solvents such as ethanol and ether. Due to the principle of similar phase solubility, its molecules have certain hydrophobicity, and can form similar forces with organic solvent molecules, so they are mutually soluble. However, its solubility in water is not good. Because of the overall hydrophobicity of the molecule, the force between the water molecule and the compound molecule is difficult to match the hydrogen bond between the water molecule, so it is difficult to dissolve.

In terms of density, after precise measurement, its density is smaller than that of water. If it is placed in the same container as water and left to stand for a while, it can be seen that it floats on the water surface, just like oil floats on the water. This is due to the way molecules are piled up and the distribution of mass.

In addition, α-methyl-6-quinoline ethyl acetate has a certain degree of volatility. It is placed in the air open, and after a period of time, its amount will decrease. This is because some molecules obtain enough energy to escape from the liquid phase and spread into the air. This volatility is also related to temperature. The higher the temperature, the stronger the volatility.

What are the main uses of -Methyl-6-quinolineacetic acid ethyl ester?

α-methyl-6-quinoline ethyl acetate is an organic compound. It has a wide range of uses and has made significant contributions to the field of medicinal chemistry.

In the process of drug research and development, it is often used as a key intermediate. Many drug molecules with specific biological activities rely on α-methyl-6-quinoline ethyl acetate as the starting material or key structural fragment in their synthesis process. Through the wonderful method of organic synthesis, its chemical structure can be modified and transformed to create new drugs with unique pharmacological properties to deal with diseases such as anti-infection and anti-tumor.

In the field of materials science, it has also emerged. Due to its specific chemical structure and physical properties, it can participate in the preparation of functional materials. For example, in the synthesis of some organic optoelectronic materials, α-methyl-6-quinoline ethyl acetate can endow the materials with unique optical or electrical properties, paving the way for the development of new optoelectronic devices.

In addition, in the study of organic synthetic chemistry, α-methyl-6-quinoline ethyl acetate is an important research object. By exploring its chemical reaction characteristics, chemists can open up novel synthesis methods and paths, expand the boundaries of organic synthetic chemistry, and provide possibilities for the synthesis of more complex organic compounds. Overall, α-methyl-6-quinoline ethyl acetate plays an indispensable role in many fields and has made extraordinary contributions to promoting the progress of science and technology.

What are the preparation methods of α -Methyl-6-quinolineacetic acid ethyl ester?

The method of preparing α-methyl-6-quinoline ethyl acetate has existed in ancient times, and with the evolution of time, the method has become more and more abundant. The following are the common preparation methods.

First, using 6-quinoline ethyl acetate as the starting material, to obtain α-methyl-6-quinoline ethyl acetate, 6-quinoline ethyl acetate can interact with methylation reagents. Common methylation reagents, such as iodomethane and dimethyl sulfate, can interact with methylation reagents. This reaction usually requires the help of a base to grab the hydrogen atom at the alpha-position of 6-quinoline ethyl acetate, so that it forms a carbon negative ion, and then the carbon negative ion undergoes a nucleophilic substitution reaction with the methylation reagent to obtain the final target product. Commonly used bases include potassium carbonate, sodium hydride, etc. For example, in a suitable organic solvent, such as N, N-dimethylformamide (DMF), 6-quinoline ethyl acetate, iodomethane and potassium carbonate are co-located, stirred at controlled temperature, and after a certain period of time, α-methyl-6-quinoline ethyl acetate can be obtained.

Second, 6-quinoline formaldehyde is used as the starting material. First, the Knoevenagel condensation reaction between 6-quinoline formaldehyde and diethyl malonate is carried out under alkali catalysis to generate the corresponding alkenyl ester. Commonly used bases include organic bases such as piperidine. Subsequently, the obtained alkenyl ester is reduced. For example, by catalytic hydrogenation, using palladium carbon as a catalyst and hydrogen as a reducing agent, the alkenyl ester can be reduced to 6-quinoline ethyl acetate. Then according to the above methylation steps, it is reacted with methylating reagents to obtain α-methyl-6-quinoline ethyl acetate.

Third, it can be prepared by organometallic reagents. For example, an organolithium reagent or Grignard reagent containing quinoline structure is first prepared, and then reacted with α-halogenated ethyl acetate. If 6-bromoquinoline is used as a raw material and reacts with lithium metal at low temperature to make 6-quinoline lithium reagent, and then reacts with α-chloroacetate, the synthesis of α-methyl-6-quinoline ethyl acetate can also be achieved.

All preparation methods have advantages and disadvantages, and it is necessary to carefully weigh and choose the most suitable method according to the actual situation, such as the availability of raw materials, the difficulty of reaction conditions, and the purity requirements of the product.

What are the precautions for α -Methyl-6-quinolineacetic acid ethyl ester during storage and transportation?

I look at what you call "α-Methyl-6-quinolineacetic acid ethyl ester", which is an organic compound. During storage and transportation, many matters should be paid attention to.

First, when storing, choose a cool, dry and well-ventilated place. This compound is afraid of moisture and moisture. If it is in a humid place, it may cause it to deteriorate, which will affect the quality. And the temperature should also be suitable. If it is too high, the temperature may cause a chemical reaction, which will damage its stability.

Second, during transportation, the protection must be comprehensive. Make sure that the packaging is tight to prevent package damage and material leakage due to vibration and collision. And the means of transport should also be clean, no other chemical residues, so as not to react with it.

Furthermore, because it is a chemical, whether it is stored or transported, it must follow relevant regulations and safety standards. Operators must have professional knowledge and skills, and know how to deal with emergencies. In case of emergencies such as leaks, appropriate measures can be taken quickly to avoid the expansion of hazards.

In addition, the storage area should be kept away from fire and heat sources. This compound may be flammable, and in case of open flames or hot topics, it may be dangerous to burn or explode.

All of these are things that should be taken into account when storing and transporting "α-Methyl-6-quinolineacetic acid ethyl ester", so as to ensure its safety and quality.