9-fluoro-5-methyl-1-oxo-6, 7-dihydro-1H, 5H-pyrido [3,2,1-ij] quinoline-2-carboxylic acid

9-Fluoro-5-methyl-1-oxo-6,7-dihydro-1H, 5H-pyridino [3,2,1-ij] quinoline-2-carboxylic acid, this is an organic compound. Looking at its name, its structure can be deduced according to the naming rules of organic chemistry.

"Pyridino [3,2,1-ij] quinoline", indicating that its core structure is a fused pyridine and quinoline, and it is connected in a specific position. " 9-Fluorine ", Ming 9 position has fluorine atom substitution;" 5-methyl ", Table 5 position is connected with methyl;" 1-oxo ", refers to No. 1 position as carbonyl (= O);" 6,7-dihydro-1H, 5H ", saying that the 6 and 7 positions are double bond hydrogenation, and the 1 and 5 positions are hydrogen atoms;" 2-carboxylic acid ", know that the 2 position is connected with carboxyl (-COOH).

Its structure is roughly as follows: pyridine-quinoline fused ring is used as the parent nucleus, No. 9 carbon-fluorine atom, No. 5 carbon-methyl, No. 1 carbon is carbonyl carbon, No. 2 carbon-carboxyl, and No. 6 and 7 are saturated carbons. In this way, the chemical structure of this compound can be obtained according to the name.

What are the main uses of 9-fluoro-5-methyl-1-oxo-6, 7-dihydro-1H, 5H-pyrido [3,2,1-ij] quinoline-2-carboxylic acid

9 - fluoro - 5 - methyl - 1 - oxo - 6,7 - dihydro - 1H, 5H - pyrido [3,2,1 - ij] quinoline - 2 - carboxylic acid, that is, 9 - fluoro - 5 - methyl - 1 - oxo - 6,7 - dihydro - 1H, 5H - pyrido [3,2,1 - ij] quinoline - 2 - carboxylic acid, which is mostly used in the field of medicinal chemistry.

It is of great significance in the development of antibacterial drugs. Taking quinolones as an example, these compounds are often used as key intermediates. Because quinolones exhibit strong antibacterial activity by inhibiting bacterial DNA gyrase or topoisomerase IV. The unique structure of 9-fluoro-5-methyl-1-oxo-6,7-dihydro-1H, 5H-pyrido [3,2,1-ij] quinoline-2-carboxylic acid can optimize the antibacterial spectrum of quinolones, enhance antibacterial efficacy and improve pharmacokinetic properties. Like some new quinolone antibacterial drugs, after introducing this structure, it exhibits excellent antibacterial activity against Gram-positive bacteria, negative bacteria, and even anaerobic bacteria, and is well absorbed in the body, widely distributed, and has a suitable half-life elimination. It provides effective drug selection for the clinical treatment of various infectious diseases.

It is also an important tool in pharmaceutical chemistry research. Scientists explore the structure-activity relationship by modifying and modifying its structure, laying the foundation for the development of more efficient and safe antibacterial drugs. For example, changing the position of fluorine atoms, adjusting groups such as methyl groups, and observing the effect on drug activity and toxicity, so as to design more advantageous antibacterial compounds. In addition, in the field of organic synthesis, it can be used as a starting material or key intermediate to participate in the construction of complex organic molecules, providing new paths and methods for the synthesis of organic compounds with specific biological activities or functions, and promoting the development of organic synthesis chemistry.

9-fluoro-5-methyl-1-oxo-6, 7-dihydro-1H, 5H-pyrido [3,2,1-ij] What are the physical properties of quinoline-2-carboxylic acid

9-Fluoro-5-methyl-1-oxo-6,7-dihydro-1H, 5H-pyridino [3,2,1-ij] quinoline-2-carboxylic acid, this is an organic compound. Its physical properties are crucial for its application in various fields.

First, the appearance is often white to light yellow crystalline powder at room temperature and pressure. This form makes the substance easy to store and transport, because it is relatively stable and does not easily change significantly under normal conditions. The melting point of

is also one of the important physical properties. Its melting point is in a specific temperature range. This characteristic can be used to identify the compound and also help to control the reaction process and product purity during the synthesis process. Accurately knowing the melting point can help chemists determine whether the prepared product is pure. If the melting point deviates from the expected range, it may suggest that the product contains impurities.

In terms of solubility, the substance exhibits specific solubility properties in organic solvents. In some polar organic solvents, such as dimethyl sulfoxide (DMSO), it has a certain solubility, but relatively low solubility in water. This difference in solubility is of great significance in separation, purification, and formulation development. In the field of drug research and development, if it is to be made into a suitable dosage form, its solubility needs to be fully considered in order to better exert the drug effect.

In addition, the density of the compound also has certain research value. The density affects its sedimentation and dispersion in solution. In chemical production and experimental operations, density data is indispensable for the control of material ratio and reaction system stability.

From the perspective of spectral properties, its characteristic peaks such as infrared spectrum and nuclear magnetic resonance spectroscopy are like the unique "fingerprint" of the compound, which can accurately reflect the molecular structure information. With the help of spectral analysis, chemists can deeply explore the connection mode and spatial configuration of each atom in the molecule, laying the foundation for further research on its chemical properties and reaction mechanism.

In summary, the physical properties of 9-fluoro-5-methyl-1-oxo-6,7-dihydro-1H, 5H-pyridino [3,2,1-ij] quinoline-2-carboxylic acids, from appearance, melting point, solubility, density to spectral characteristics, play a crucial role in their research and application, providing a key basis for the exploration of many fields.

What are the synthesis methods of 9-fluoro-5-methyl-1-oxo-6, 7-dihydro-1H, 5H-pyrido [3,2,1-ij] quinoline-2-carboxylic acid

9 - fluoro - 5 - methyl - 1 - oxo - 6,7 - dihydro - 1H, 5H - pyrido [3,2,1 - ij] quinoline - 2 - carboxylic acid, that is, 9 - fluoro - 5 - methyl - 1 - oxo - 6,7 - dihydro - 1H, 5H - pyrido [3,2,1 - ij] quinoline - 2 - carboxylic acid, and there are many synthesis methods, which are briefly described by you below.

First, a compound containing the structure of pyridine and quinoline is used as the starting material. After the halogenation reaction, halogen atoms are introduced to lay the foundation for the subsequent reaction. The selected halogenating reagents are different, and the reaction conditions need to be carefully regulated to achieve the ideal halogenation effect. Then, through the nucleophilic substitution reaction, fluorine atoms and methyl groups are introduced. The selection of nucleophilic reagents is the key, and their activity and selectivity determine the reaction process and product purity. During the reaction process, factors such as solvent, temperature, and time need to be carefully considered to promote the reaction to proceed efficiently in the direction of the target product.

Second, through the strategic synthesis of building a pyridine-quinoline skeleton. With suitable aromatic compounds and nitrogen-containing heterocyclic compounds as starting materials, the core skeleton is constructed through cyclization reaction. The reaction may require a specific catalyst. The type and dosage of the catalyst, as well as the pH and temperature of the reaction environment, all have a great impact on the rate and selectivity of the cyclization reaction. After the skeleton is formed, functional groups such as carbonyl and carboxyl groups are introduced through modification steps such as oxidation and substitution. The oxidation process requires the selection of appropriate oxidants to ensure precise control of the degree of oxidation and obtain the specific structure of the target product.

Third, the idea of total synthesis of natural products is adopted. Seek natural products with similar structural fragments as a starting point. After gradual modification and transformation, the synthesis to the target compound is realized. This approach requires in-depth understanding of the structure and reactivity of natural products, clever use of their inherent structural characteristics, reducing reaction steps and improving synthesis efficiency. The stability of the natural product source and the difficulty of extraction and separation are also key points to consider.

When synthesizing this compound, every step of the reaction needs to be precisely controlled, from raw material selection, reaction conditions optimization, to product separation and purification, all of which are related to the quality and yield of the final product. Experimenters need deep organic synthesis skills and rich practical experience to find an efficient and feasible synthesis path.

9-fluoro-5-methyl-1-oxo-6, 7-dihydro-1H, 5H-pyrido [3,2,1-ij] What are the common specifications of quinoline-2-carboxylic acid on the market?

9 - fluoro - 5 - methyl - 1 - oxo - 6,7 - dihydro - 1H, 5H - pyrido [3,2,1 - ij] quinoline - 2 - carboxylic acid, the Chinese name is often 9 - fluoro - 5 - methyl - 1 - oxo - 6,7 - dihydro - 1H, 5H - pyridino [3,2,1 - ij] quinoline - 2 - carboxylic acid, this is a common specification in the city, Rong Wu is your detailed description.

Common specifications, mostly purity. Such as high purity, it can reach more than 98%. This kind of product is often used in high-end pharmaceutical research and development. Due to its low number of impurities, it has little interference with experimental results. When exploring new drug ingredients and pharmacological mechanisms, it can provide researchers with accurate raw materials and make the research path clearer.

There are also those with a purity of about 95%. This specification is quite common in the field of chemical synthesis. Because it can meet the needs of general organic synthesis, when preparing related derivatives or performing specific reactions, it can be used at a relatively reasonable cost to obtain the expected reaction products, reducing costs and improving efficiency for industrial production.

In addition to purity specifications, packaging specifications are also different. Small packages are commonly used in grams, such as 1 gram, 5 grams, and 10 grams. These are mostly suitable for initial experiments in scientific research institutes, which is convenient for researchers to use on demand, accurately control the dosage, and reduce material waste. Large packages are used in kilograms, 5 kilograms, 10 kilograms, or even more. They are mainly aimed at large-scale production enterprises to meet their long-term and large-scale production needs and ensure the continuity of the production process.

In addition, their morphological specifications also vary. Or white to light yellow crystalline powder, this form is easy to weigh, dissolve and mix, and can be quickly dispersed in various reaction systems, which is conducive to the full progress of the reaction. It is also made into granular materials, which are easy to store and transport. It is not easy to deteriorate due to extrusion and vibration during logistics circulation, and is more suitable for long-distance and long-term transportation.