8-cyano-1-cyclopropyl-6-fluoro-7- [ (4aS, 7aS) -octahydro-6H-pyrrolo [3,4-b] pyridin-6-yl] -4-oxo-1,4-dihydroquinoline-3-carboxylic acid?

This is the name of 8-cyano-1-cyclopropyl-6-fluoro-7- [ (4aS, 7aS) -octahydro-6H-pyrrolo [3,4-b] pyridine-6-yl] -4-oxo-1,4-dihydroquinoline-3-carboxylic acid. To know its chemical structure, let me tell you in detail.

Looking at its name, this compound contains quinoline parent nucleus. The structure of 1,4-dihydroquinoline-4-one is its core framework. It is connected with a cyclopropyl group at the 1st position, which adds to the rigidity and unique spatial structure of its molecule. The introduction of fluorine atoms at the 6th position has strong electronegativity, which can significantly change the physical and chemical properties of compounds, such as lipophilicity, electron cloud distribution, etc., and has a great impact on their biological activities.

8-position cyano group has strong electron absorption, can further adjust the electron cloud density of molecules, and can participate in a variety of chemical reactions, contributing a lot to the reactivity and biological activity of compounds. < Br >
3-carboxyl group, an acidic group, can ionize hydrogen ions, affect the acidity and solubility of compounds, and play a key role in forming hydrogen bonds and interacting with biological targets.

And the 7-linked [ (4aS, 7aS) -octahydro-6H-pyrrolido [3,4-b] pyridine-6-yl], this complex cyclic structure contains multiple chiral centers, and (4aS, 7aS) indicates its three-dimensional configuration. This structure endows the molecule with a unique spatial conformation, which is crucial for its specific binding to biological macromolecules, such as with specific receptors or enzymes, and greatly affects the biological activity and selectivity of the compound.

In summary, the chemical structure of this compound is composed of quinoline parent nucleus and many different substituents. Each substituent works together to determine its unique physical, chemical and biological properties.

What are the main uses of 8-cyano-1-cyclopropyl-6-fluoro-7- [ (4aS, 7aS) -octahydro-6H-pyrrolo [3,4-b] pyridin-6-yl] -4-oxo-1,4-dihydroquinoline-3-carboxylic acid?

8-Cyano-1-cyclopropyl-6-fluoro-7- [ (4aS, 7aS) -octahydro-6H-pyrroso [3,4-b] pyridine-6-yl] -4-oxo-1,4-dihydroquinoline-3-carboxylic acid, this is the name of the chemical substance. Its main use is quite critical, and it is mostly used in the field of medicine.

The structure of this compound is rich in specific functional groups, such as cyano, fluorine atoms, etc., giving it unique chemical activities and properties. In pharmaceutical research and development, such structures are often the cornerstone of the creation of antibacterial drugs.

Geinquinoline carboxylic acids have excellent antibacterial properties and can effectively inhibit bacterial growth and reproduction. This compound is cleverly designed to introduce cyclopropyl, specific nitrogen-containing heterocycles and other structures, which may enhance antibacterial activity, expand the antibacterial spectrum, and improve pharmacokinetic properties, such as improving bioavailability and prolonging the time of action in vivo.

In addition, it has high selectivity for specific bacterial targets, or can accurately target pathogenic bacteria, and has little impact on normal human cells, which can reduce drug side effects and improve therapeutic effects. Therefore, 8-cyano-1-cyclopropyl-6-fluoro-7- [ (4aS, 7aS) -octahydro-6H-pyrrole [3,4-b] pyridine-6-yl] -4-oxo-1,4-dihydroquinoline-3-carboxylic acid plays an important role in the development of antibacterial drugs, providing powerful weapons for human beings to resist bacterial infections.

8-cyano-1-cyclopropyl-6-fluoro-7- [ (4aS, 7aS) -octahydro-6H-pyrrolo [3,4-b] pyridin-6-yl] -4-oxo-1,4-dihydroquinoline-3-carboxylic acid What are the synthesis methods?

8-Cyano-1-cyclopropyl-6-fluoro-7- [ (4aS, 7aS) -octahydro-6H-pyrroso [3,4-b] pyridine-6-yl] -4-oxo-1,4-dihydroquinoline-3-carboxylic acid, this is an important organic compound, and the synthesis method is quite critical.

Common synthesis paths, the selection of starting materials is very important. Quinoline derivatives with specific substituents can be selected first, and the reaction can be carried out based on them.

One method is to first make the quinoline derivative react with a cyclopropyl-containing reagent under specific reaction conditions. Cyclopropyl can be introduced to a specific position of the quinoline structure through mechanisms such as nucleophilic substitution to generate 1-cyclopropyl-quinoline derivatives.

Next, a cyano group is introduced. A suitable cyanide reagent can be used to obtain 8-cyano-1-cyclopropyl-quinoline derivatives in a suitable reaction environment, such as in the presence of a catalyst, a suitable temperature and a solvent system.

The introduction of fluorine atoms can be achieved at the 6-position fluoride substitution under suitable conditions by means of special fluorination reagents, according to the characteristics of the fluorination reaction, to obtain 8-cyano-1-cyclopropyl-6-fluoro-quinoline derivatives.

As for the introduction of the 7- [ (4aS, 7aS) -octahydro-6H-pyrrolido [3,4-b] pyridine-6-yl] part, the corresponding pyrrolido-pyridine derivatives must be synthesized first, and then precisely linked at the 7-position through a series of reactions such as condensation and substitution.

Finally, the structure of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid was constructed, which can be achieved by oxidation, carboxylation and other reaction steps. During the whole synthesis process, the control of reaction conditions, the purification and identification of intermediates are all crucial, which are related to the purity and yield of the final product.

What are the pharmacological properties of 8-cyano-1-cyclopropyl-6-fluoro-7- [ (4aS, 7aS) -octahydro-6H-pyrrolo [3,4-b] pyridin-6-yl] -4-oxo-1,4-dihydroquinoline-3-carboxylic acid?

8-Cyano-1-cyclopropyl-6-fluoro-7- [ (4aS, 7aS) -octahydro-6H-pyrroso [3,4-b] pyridine-6-yl] -4-oxo-1,4-dihydroquinoline-3-carboxylic acid, this is the name of the chemical substance, and its related pharmacological properties are particularly important.

Its antibacterial activity is quite strong, and it has excellent inhibitory effect on both Gram-positive and negative bacteria. For common negative bacteria such as Escherichia coli and Klebsiella pneumoniae, as well as positive bacteria such as Staphylococcus aureus, it can show strong antibacterial power, which can effectively inhibit the growth and reproduction of bacteria, making it difficult for bacteria to wreak havoc.

Furthermore, its ability to penetrate bacterial cell membranes is outstanding. It can easily cross bacterial cell membranes and reach the target of action, just like a sharp blade to break through bamboo and directly attack Huanglong, and then efficiently exert its antibacterial ability, greatly improving the efficiency of antibacterial.

And it is widely distributed in the body, and can penetrate into various tissues and body fluids of the body, such as blood, tissue fluids, etc. In this way, no matter where the bacteria are hidden, they can be found and attacked, thus having the potential to treat infections all over the body.

In addition, the safety of this substance is also quite high. Under the appropriate dose, there are few adverse reactions, and the human body tolerates it well. There is no need to worry too much about safety when using it. It is like a reliable companion and provides strong support for the treatment of infectious diseases.

8-cyano-1-cyclopropyl-6-fluoro-7- [ (4aS, 7aS) -octahydro-6H-pyrrolo [3,4-b] pyridin-6-yl] -4-oxo-1,4-dihydroquinoline-3-carboxylic acid competitive advantage in the market?

8-Cyano-1-cyclopropyl-6-fluoro-7- [ (4aS, 7aS) -octahydro-6H-pyrroso [3,4-b] pyridine-6-yl] -4-oxo-1,4-dihydroquinoline-3-carboxylic acid, which is a specific compound in the field of chemistry. On the market, its competitive advantages are manifested in many aspects.

In terms of the pharmaceutical industry, this compound may have unique pharmacological activities or may become a key raw material for the development of new antimicrobial drugs. Nowadays, the demand for antibacterial drugs is urgent, and new antibacterial ingredients are very popular. This compound has a unique chemical structure, which may endow it with a novel antibacterial mechanism. It can deal with bacteria that are difficult to overcome by existing drugs. Compared with traditional antibacterial drugs, it may have a wider antibacterial spectrum and stronger antibacterial activity. This is a weapon for its competition in the pharmaceutical market.

At the research and development level, the complex structure of this compound brings challenges to researchers and also provides opportunities for innovation. If the R & D team can successfully control its synthesis and application, it can stand out in the market competition with its technological leadership. Furthermore, if a series of derivative drugs can be developed based on this compound, the product line can be further enriched and market competitiveness enhanced.

In the production process, if an enterprise can build an efficient and green synthesis process, achieve large-scale stable production, and ensure uniform product quality, it can reduce costs and gain a competitive advantage in price. At the same time, environmentally friendly production processes are also in line with the current development trend of green chemistry, and are easy to gain market recognition and policy support. These are all important advantages of 8-cyano-1-cyclopropyl-6-fluoro-7- [ (4aS, 7aS) -octahydro-6H-pyrrolio [3,4-b] pyridine-6-yl] -4-oxo-1,4-dihydroquinoline-3-carboxylic acid in market competition.