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What is the main use of 8- (3,4-dihydroisoquinoline-2 (1H) -ylsulfonyl) quinoline?
8- (3,4 -dihydroisobenzofuran-2 (1H) -ylcarbonyl) benzofuran, this substance has key uses in the chemical and pharmaceutical fields.
In the chemical industry, it is often used as a key monomer for the synthesis of special polymer materials. With its unique chemical structure, polymers with special properties can be constructed through polymerization, such as in the synthesis of organic optoelectronic materials, which can improve the photoelectric conversion efficiency and stability of the material. This is because the conjugate structure of the substance helps to transport electrons, thereby optimizing the electrical properties of the material.
In the field of medicine, it is an important pharmaceutical intermediate. Using it as a starting material, a variety of biologically active compounds can be synthesized through a series of chemical reactions. Like some targeted therapies for specific diseases, with the help of p-8- (3,4-dihydroisobenzofuran-2 (1H) -ylcarbonyl) benzofuran structural modification and modification, drug molecules with high affinity and selectivity for disease-related targets can be obtained, thereby improving drug efficacy and reducing side effects. In the development of anti-cancer drugs, scientists have successfully prepared new compounds with high inhibitory activity against certain cancer cells by optimizing the structure of this substance.
What are the synthesis methods of 8- (3,4-dihydroisoquinoline-2 (1H) -ylsulfonyl) quinoline
To prepare 8- (3,4-dioxyisobenzofuran-2 (1H) -yl) benzaldehyde, the method is as follows:
First take catechol and react it with chloroacetic acid in an alkaline environment to obtain 3,4-dihydroxyphenylacetic acid. In this step, the temperature should be controlled moderately and stirred evenly to make the reaction sufficient.
Then the 3,4-dihydroxyphenylacetic acid is co-heated with acetic anhydride to undergo acetylation reaction to obtain 3,4-diacetoxyphenylacetic acid. When reacting, pay attention to the heat and do not cause the product to decompose due to excessive temperature.
Next, 3,4-diacetoxyisobenzofuran-1 (3H) -one is obtained by intramolecular cyclization of 3,4-diacetoxyisobenzofuran-1 (3H) -one with concentrated sulfuric acid as catalyst. In this process, the amount of concentrated sulfuric acid needs to be accurate and the drip rate should be appropriate.
Subsequently, 3,4-diacetoxyisobenzofuran-1 (3H) -one is hydrolyzed, and the acetyl group is deacetylated to obtain 3,4-dihydroxyisobenzofuran-1 (3H) -one. The hydrolysis conditions are mild to maintain the stability of the product.
Then oxidize 3,4-dioxyisobenzofuran-1 (3H) -one to 3,4-dioxyisobenzofuran-2 (1H) -one with a suitable oxidant. The choice of oxidant needs to be cautious, depending on the reaction conditions and product requirements.
Finally, the Suzuki coupling reaction of 3,4-dioxyisobenzofuran-2 (1H) -one with p-formylphenylboronic acid results in 8- (3,4-dioxyisobenzofuran-2 (1H) -yl) benzaldehyde. In the reaction, the choice of catalyst, base and reaction solvent is crucial, which affects the success or failure of the reaction and the yield.
Each step of the reaction requires fine operation, attention to the control of reaction conditions, such as temperature, pH, reaction time, etc., and the separation and purification of the product cannot be ignored, so as to obtain the target product efficiently.
What are the physicochemical properties of 8- (3,4-dihydroisoquinoline-2 (1H) -ylsulfonyl) quinoline
The physicochemical properties of 8- (3,4-dioxyisopentene-2 (1H) -sulfonylamino) pentene are as follows:
This substance has a unique structure. In terms of physical properties, its appearance may vary depending on the specific state. It may be a solid or a liquid at room temperature. Key physical constants such as melting point and boiling point are determined based on its intermolecular forces and structural characteristics. Due to the presence of multiple specific functional groups in the molecule, the interaction between these functional groups and the surrounding environment will affect its melting boiling point.
Chemically, it has a certain reactivity because of its dioxyisopentene structure and sulfonylamino group. The double bond part of the dioxy isoprene structure may undergo an addition reaction, such as with halogens, hydrogen halides and other electrophilic reagents, to form new compounds. The nitrogen atom in the sulfonylamino group has lone pair electrons and has certain nucleophilic properties, which can participate in nucleophilic substitution reactions, such as reacting with halogenated hydrocarbons to form new nitrogen-containing derivatives. At the same time, the substance may also participate in redox reactions under suitable conditions. The specific reaction path and product depend on the oxidizing or reducing agent used in the reaction and the reaction conditions. Overall, the physicochemical properties of 8- (3,4-dioxy-isoprene-2 (1H) -sulfonylamino) pentene are determined by its molecular structure and exhibit diverse chemical behaviors in different reaction environments.
What is the market price of 8- (3,4-dihydroisoquinoline-2 (1H) -ylsulfonyl) quinoline?
Today there are 8- (3,4-dioxy isosquinone acid-2 (1H) -ylthiazolyl) square acids in the market, what is the price? I will imitate the body of "Tiangong Kaiwu" and describe it in ancient text.
Gai Wen is trading in various stores, and each product has a price. The price of this 8- (3,4-dioxy isosquinone acid-2 (1H) -ylthiazolyl) square acid in the market is difficult to determine. The level of its price depends on many factors.
One is the place where it comes from. If the production is good, the materials are abundant, and the production is convenient, the price will be flat. If its source is sparse, it is difficult to harvest, and the system is cumbersome, the price will increase.
Second, the quality is good or bad. Those with high purity and few impurities are excellent products, and the price is not cheap. If it contains a lot of heterogeneity, the quality is not pure, and the price should be inferior.
Third, the supply and demand of the city. If there are many people who want it, and there are few people who supply it, the price will go up; if supply exceeds demand, the price will automatically drop.
Fourth, the cost of production and sales. Fees such as harvesting, refining, storage and transportation, taxes, etc. are all included in the price. The cost is high if it is complicated, and the price is low if it is simple. < Br >
Therefore, if you want to know the exact price of this 8- (3,4-dioxy isosquanoic acid-2 (1H) -ylthiazolyl) square acid in the market, you should carefully consider its source, quality, supply and demand, and the cost of production and sales. In the market, Jia people also weigh various ends according to the changes of time to set the price. Or you can consult the pharmacy and chemical shop, and negotiate with Jia to get the exact price.
What is the relevant safety information of 8- (3,4-dihydroisoquinoline-2 (1H) -ylsulfonyl) quinoline?
"Tiangong Kaiwu" says: "8 -% 283% 2C4 - dioxoisobutyric acid - 2% 281H% 29 - thiazolyl% 29 - butyric acid light is a matter of safety and is quite important. The material used in this light must be pure in quality. If there are impurities, the light color may be different, and it is prone to danger.
Those who make this light should choose the best material with a strict method. During operation, it is necessary to observe changes in temperature and heat. If the temperature is too high, the material will be vulnerable, and the light will be abnormal; if the temperature is too low, the reaction will be slow, and the light will not be effective.
Also, the environment where this light is located should also be paid attention to. If you are in a humid place, the light body is perishable, causing the light color to be dim, or even extinguished; if you are in a hot and dry place, there is a risk of explosion.
Furthermore, the person who handles it must be familiar with its skills and be careful. A slight mistake will lead to disaster. You must follow the law, and you must not act on your own. In this way, the light of 8 -% 283% 2C4 -dioxoisobutyric acid - 2% 281H% 29 -thiazolyl% 29 butyric acid will be safe for your needs, and there will be no safety. "