7-CHLORO-6-FLUORO-1-(4-FLUOROPHENYL)-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLICACID

7-Chloro-6-fluoro-1- (4-fluorophenyl) -1,4-dihydro-4-oxyquinoline-3-carboxylic acid is a crucial intermediate in the field of organic synthesis. It has a wide range of uses and is of great significance in the field of medicinal chemistry.
Bearing the brunt, this compound plays a key role in the development and preparation of antibacterial drugs. It is an important starting material for the synthesis of many new quinolone antibacterial drugs. With its unique antibacterial mechanism, quinolone antibacterial drugs exhibit excellent antibacterial activity against Gram-positive and negative bacteria and many other pathogens. The structural properties of 7-chloro-6-fluoro-1- (4-fluorophenyl) -1,4-dihydro-4-oxyquinoline-3-carboxylic acid lay the foundation for the construction of highly effective antibacterial active molecules. By modifying and modifying its structure, the antibacterial spectrum of the drug can be optimized, the antibacterial efficacy can be improved, and the pharmacokinetic properties of the drug can be improved, such as enhancing the absorption, distribution, metabolism and excretion characteristics of the drug, thereby enhancing the overall therapeutic effect of the drug.
Furthermore, in the field of pesticides, this compound has also been involved. With the advancement of agricultural modernization, the demand for high-efficiency, low-toxicity and environmentally friendly pesticides is increasing day by day. Pesticides developed on the basis of 7-chloro-6-fluoro-1- (4-fluorophenyl) -1,4-dihydro-4-oxoquinoline-3-carboxylic acid may have unique insecticidal, bactericidal or herbicidal activities. By ingeniously designing its derived structure, it is expected to achieve precise control of specific crop diseases and pests, while reducing the impact on non-target organisms, in line with the development concept of modern green agriculture.
In addition, in the field of materials science, although it is not widely used, its potential value cannot be ignored. Due to its specific electronic structure and chemical properties, it can be used to prepare organic materials with special optical and electrical properties. For example, through rational molecular design and assembly, or materials with fluorescent properties can be synthesized, which have emerged in the fields of optical sensors, Light Emitting Diodes, etc.; or because some groups in the structure can interact with specific materials, they can be used in surface modification of materials to improve surface properties such as hydrophobicity and adhesion of materials.

The synthesis of 7-chloro-6-fluoro-1- (4-fluorophenyl) -1,4-dihydro-4-oxyquinoline-3-carboxylic acid is an interesting topic in organic synthetic chemistry. In the past, many researchers have explored the synthesis of this compound, and the methods are also diverse and complicated.
One method is to use fluorobenzene-containing compounds as starting materials. First, fluorobenzene and a specific halogen are catalyzed by a base to undergo nucleophilic substitution. In this process, the choice of base is very critical, such as potassium carbonate, sodium carbonate, etc. The dosage, reaction temperature and time need to be carefully regulated. When the nucleophilic substitution is successfully completed, an intermediate is obtained.
Then, this intermediate and another quinoline precursor compound containing chlorine and fluorine are catalyzed by a specific catalyst in a suitable solvent to carry out cyclization. Commonly used solvents such as toluene, xylene, etc., catalysts such as some transition metal complexes. After this cyclization, the quinoline skeleton of the target compound can be preliminarily constructed. However, the product may need to be further modified at this time.
The second method uses quinoline carboxylic acid as the base parent. First, the specific position of the halogenation reaction is carried out to introduce chlorine atoms and fluorine atoms. The choice of halogenating reagents is of paramount importance. If suitable chlorine-containing and fluorohalogenating agents are selected, under appropriate reaction conditions, fluorine atoms can be introduced at the 6th position of the quinoline ring and chlorine atoms at the 7th position. After that, 4-fluorophenyl groups can be introduced into the 1st position through arylation. This arylation reaction often requires a palladium-catalyzed system. Factors such as the choice of ligands, reaction temperature and time will affect the yield and selectivity of the reaction.
Furthermore, other heterocyclic compounds are also used as starting materials and converted into target products through multi-step reactions. First, the heterocyclic ring was opened or expanded to construct an intermediate with a partial structure similar to the target compound. Then, chlorine, fluorine atoms and 4-fluorophenyl were gradually introduced, and after multi-step modification and improvement, 7-chloro-6-fluoro-1- (4-fluorophenyl) -1,4-dihydro-4-oxyquinoline-3-carboxylic acid was finally obtained. During each step of the reaction, the separation and purification of the intermediate should not be ignored. Methods such as column chromatography and recrystallization should be used to ensure the purity of the product and improve the efficiency and quality of the synthesis.

7-Chloro-6-fluoro-1- (4-fluorophenyl) -1,4-dihydro-4-oxyquinoline-3-carboxylic acid, this is an organic compound. Looking at its physical and chemical properties, this substance is often in a solid state, but the specific properties may vary depending on the preparation method and purity.
Regarding the melting point, the compound has a high melting point. Due to the existence of various forces between molecules, such as van der Waals force, hydrogen bonds, etc., the molecules are closely arranged, and more energy is required to disintegrate its lattice structure and melt the substance. < Br >
Its solubility is either slightly soluble or insoluble in common organic solvents. This is because in the molecular structure, although the carboxyl group can form a hydrogen bond with some solvents, at the same time, the hydrophobic groups such as benzene ring and quinoline ring account for a large proportion, resulting in poor overall hydrophilicity. In water, it is also difficult to dissolve due to the partial influence of hydrophobicity.
In terms of chemical properties, the carboxyl group has a high activity and can neutralize with bases to form corresponding carboxylate salts. This reaction is often used in organic synthesis to separate and purify the compound. At the same time, due to the existence of a conjugated system in the molecule, it has certain stability. However, under specific conditions, such as strong oxidants and high temperatures, the conjugated system may be destroyed, triggering a chemical reaction. In addition, although halogen atoms (chlorine, fluorine) are relatively stable, they can also participate in the substitution reaction under appropriate catalyst and reaction conditions, providing more possibilities for organic synthesis.
In short, the physicochemical properties of 7-chloro-6-fluoro-1 - (4-fluorophenyl) -1,4-dihydro-4-oxyquinoline-3-carboxylic acids determine their application direction and mode in organic synthesis, pharmaceutical chemistry and other fields.

7-Chloro-6-fluoro-1- (4-fluorophenyl) -1,4-dihydro-4-oxyquinoline-3-carboxylic acid, which is a class of high-profile compounds in the field of pharmaceutical and chemical industry, plays a key role in the development of many drugs.
As for its market price, it is difficult to give an exact number directly. Gai because its price is like a smart water, often varies with many factors. The first one to bear the brunt is the cost of raw materials. The synthesis of this compound requires various specific raw materials. If the supply of raw materials is tight or encounters price fluctuations, its cost will also fluctuate, which will then affect the price of the finished product. Furthermore, the simplicity of the production process also has a significant impact. If the production process requires fine and complex steps, or special equipment and technology are required, it will undoubtedly increase production costs and cause prices to rise.
The dynamic balance of market supply and demand is also a powerful lever for prices. If many pharmaceutical companies have strong demand for it and limited supply, prices will rise; conversely, if the market is oversupplied, prices will be under pressure to decline.
In addition, different manufacturers produce different prices due to quality differences. Those with high quality often have higher prices. In terms of current market conditions, the price of this compound fluctuates widely, ranging from a few hundred yuan per kilogram to several thousand yuan. To know the exact price, you need to consult the chemical raw material supplier in detail, or refer to the real-time quotation of the professional chemical product trading platform. In this way, you can get the price information that fits the current market situation.

7-Chloro-6-fluoro-1- (4-fluorophenyl) -1,4-dihydro-4-oxoquinoline-3-carboxylic acid, this is a valuable organic compound, which is widely used in the field of medicinal chemistry and is often a key intermediate in the synthesis of antibacterial drugs. Many manufacturers are involved in the production of this compound, and today I enumerate several well-known manufacturers.
First, Zhejiang Tianyu Pharmaceutical Joint stock company, which has a long-standing reputation in the field of fine chemicals and API manufacturing. With advanced technology and strict quality control system, the company has achieved remarkable results in the production of 7-chloro-6-fluoro-1- (4-fluorophenyl) -1,4-dihydro-4-oxyquinoline-3-carboxylic acid. Its production technology is exquisite, which can ensure high quality and stable supply of products. It has a good reputation in the industry and has won the trust of many customers.
Looking at Jiangsu Hengrui Pharmaceutical joint stock company, this is a large and well-known pharmaceutical enterprise in China with strong R & D and production strength. Hengrui Pharmaceutical also attaches great importance to the production of this compound and invests a lot of resources to optimize the process. Its production process follows strict specifications, from raw material procurement to finished product delivery, all links are strictly controlled to ensure that the product quality meets high standards and meets domestic and foreign market demand.
Another Shandong Lukang Pharmaceutical joint stock company, as an important enterprise in antibiotic production, also has profound heritage in the production of related compounds. Lukang Pharmaceutical uses its own technical accumulation and scale advantages to achieve efficient production of 7-chloro-6-fluoro-1 - (4-fluorophenyl) -1,4-dihydro-4-oxyquinoline-3-carboxylic acid. The company pays attention to environmental protection and sustainable development, and practices green concepts in the production process, setting a good example for the development of the industry.
In addition to the above enterprises, there are still many small and medium-sized manufacturers active in the market. However, these well-known large factories, with their excellent quality, stable supply and deep technical accumulation, occupy an important position in the production of 7-chloro-6-fluoro-1- (4-fluorophenyl) -1,4-dihydro-4-oxyquinoline-3-carboxylic acid, leading the development direction of the industry.