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What are the chemical properties of 7-bromo-2-chloro-3-ethylquinoline?
7-Hydroxy-2-amino-3-methylpyridine, this physical property is also, its color is often colorless to light yellow liquid or crystalline, alkaline, and can form salts with acids.
In terms of its solubility, it has a certain solubility in water, alcohols such as ethanol, and ethers such as ether. This is because the polar groups such as hydroxyl and amino groups in the molecule can form hydrogen bonds with water and polar organic solvents, so they can be soluble.
Its chemical activity is quite strong. Due to the existence of amino and hydroxyl groups, the density of the electron cloud of the phenyl ring increases, and the electrophilic substitution reaction is prone to occur. In case of a halogenating agent, the halogen atom can enter the benzene ring to form a halogenated derivative; in case of an acylating agent, the amino group and hydroxyl group can be replaced by an acyl group.
Furthermore, the amino group can participate in many reactions, such as condensation with aldodes and ketones to form imines or Schiff bases. Hydroxyl groups can also participate in esterification reactions, and react with organic acids or inorganic acids to produce corresponding esters.
It has a wide range of uses in the field of organic synthesis and can be used as an intermediate for drug synthesis. Due to its structural characteristics, it can introduce various functional groups through a series of reactions to construct compounds with specific physiological activities. It can also be used in the preparation of agricultural chemicals, such as the synthesis of some insecticides and fungicides. With its chemical activity, pesticide products with high efficiency and low toxicity can be prepared.
What are the synthesis methods of 7-bromo-2-chloro-3-ethylquinoline?
7-Bromo-2-iodine-3-methylbenzoic acid is an organic compound that can be synthesized by a variety of chemical methods. Here are the common methods:
** Using benzoic acid derivatives as starting materials **:
1. ** Halogenation reaction **:
- If 3-methylbenzoic acid is used as the starting material, the bromination reaction is carried out first. Dissolve 3-methylbenzoic acid in an appropriate solvent, such as dichloromethane, add an appropriate amount of brominating reagent, such as N-bromosuccinimide (NBS), and add a small amount of initiator such as benzoyl peroxide. Under heating or lighting conditions, methyl ortho-sites can be brominated to obtain 3-methyl-2-bromobenzoic acid.
- Then proceed to iodization reaction. Put 3-methyl-2-bromobenzoic acid in a suitable solvent, such as DMF, etc., add an iodizing reagent, such as potassium iodide (KI), and add an appropriate amount of catalyst such as cuprous iodide (CuI) and ligands, and react at a certain temperature. Iodine atoms can be introduced into the ortho-position of bromine atoms to obtain 7-bromo-2-iodine-3-methylbenzoic acid.
2. ** Carboxyl group introduction reaction **:
- Using 1-methyl-2-bromo-3-iodobenzene as raw material, the Grignard reagent is first prepared. 1-Methyl-2-bromo-3-iodobenzene is dissolved in anhydrous ether and other solvents, and magnesium chips are slowly added at low temperature to react to form Grignard reagent.
- After that, carbon dioxide gas is introduced into the Grignard reagent, and then acid hydrolysis can introduce carboxyl groups on the benzene ring, thereby obtaining 7-bromo-2-iodo3-methylbenzoic acid.
** With benzene ring construction as the starting step **:
1. ** Construction of benzene ring by Fu-gram reaction and introduction of substituents **:
- Using suitable halogenated alkanes and halogenated aromatics, such as 1-bromo-2-iodine-3-chloropropane and benzene, under the catalysis of Lewis acid such as aluminum trichloride, through Fu-gram alkylation reaction, an alkyl chain with bromine and iodine atoms is introduced on the benzene ring.
- Then through oxidation reaction, such as the use of strong oxidants such as potassium permanganate, the alkyl chain is oxidized to a carboxyl group, and finally 7-bromo-2-iodine-3-methylbenzoic acid is synthesized. This process requires attention to the control of reaction conditions, because the oxidation reaction may affect the stability of bromine and iodine atoms.
When synthesizing 7-bromo-2-iodine-3-methylbenzoic acid, the appropriate method should be selected according to the actual situation, considering the availability of raw materials, the difficulty of reaction conditions, the yield and side reactions, etc., and the reaction should be finely regulated to achieve satisfactory synthesis results.
What is the main use of 7-bromo-2-chloro-3-ethylquinoline?
7-Hydroxy-2-naphthalene-3-ethylbenzyl ether is an organic compound with the following main uses:
- ** Medicinal field **: In pharmaceutical chemistry, this compound may have potential biological activity. Or it can be used as a pharmaceutical intermediate to synthesize drugs with specific curative effects. Because the structure of naphthalene ring and benzene ring is commonly found in many drug molecules, it endows the compound with a certain lipid solubility and a special spatial configuration, which is conducive to interaction with targets in vivo. For example, some drugs with such structures can act on specific enzymes or receptors, or show therapeutic potential for diseases such as inflammation and tumors.
- ** Materials Science **: In the field of materials science, or can be applied to the preparation of functional materials. Due to its special chemical structure, or endowing materials with unique optical, electrical or thermal properties. Such as in the field of organic optoelectronic materials, or can participate in the preparation of organic Light Emitting Diode (OLED) materials, with its structural characteristics, affect the luminous efficiency and color purity of materials; in the modification of polymer materials, or can be used as an additive to improve the mechanical properties and stability of materials.
- * Fragrance industry **: Its structure or endowing compounds with a special smell may have application value in the fragrance industry. Or it can be blended with other fragrance ingredients to create a unique aroma, which can be used in perfumes, air fresheners, detergents and other products to add pleasant fragrance.
What are the precautions for 7-bromo-2-chloro-3-ethylquinoline during storage and transportation?
7 - Alkyl-2-alkane-3-ethylbenzyl ether, if you are hiding it, you should pay attention to all kinds of matters. This is a special problem, and if you are hiding it, you must be in a place where things are dry and good. If you are in a place where the tide is high, it is easy to cause its nature or be damaged by decay. And it is a source of fire and heat, because it is flammable, if you are not careful, you will be in a fire.
If you are in a place, you should also be extra careful. The package must be made to prevent leakage. It is fragile, and it can be shaken and collided on the way. On the way, you should avoid heights. Exposure to the hot sun or fumigation in the summer can make it easier.
In addition, if there is any leakage, it can be properly placed as soon as possible.
In addition, all those who have been hidden must abide by the laws and regulations, and they must not do so without permission. Register the warehouse, and clarify its quantity and whereabouts, so that the management can be traced. In this way, the safety of the storage of 7-2-alkane-3-ethylbenzyl ether can be guaranteed, and the safety of all parties can be protected.
What is the market price of 7-bromo-2-chloro-3-ethylquinoline?
Today there are 7-hydroxyl-2-naphthalene-3-ethylbenzaldehyde, and the price of the market is roughly difficult to determine. The price depends on multiple ends.
The first one has a lot to do with its purity and heterogeneity. If the quality is pure and flawless, and there are very few impurities mixed, the price will be high; if the quality is uneven and contains some impurities, the price will drop from time to time.
Second, the supply and demand of the city is also the main reason. If the current industry is prosperous, and the demand for it is very strong, and the demand is too much, the price will skyrocket; if the times change, the demand is few, and the supply exceeds the demand, the price will be like a river. < Br >
Furthermore, the difficulty of making it also affects its price. If the process of making it is cumbersome, requires a lot of clever skills and precious materials, and costs money and effort, the price will be high; if it is easy to make, and what is needed is ordinary, the price will be low.
There is competition in the market, and it cannot be ignored. There are many people in the same industry, each competing for the price, in order to attract customers, or reduce its value; if there are few people in the same industry, they are almost exclusive, and the price can be independent.
Therefore, if you want to know the exact price, you must carefully observe the state of the city, the quality of the situation, the method of making and the shape of the competition. Roughly speaking, according to the current situation, the price of pure gold varies from tens to hundreds of gold per gram; the quality of inferior gold, or the number of gold per gram to tens of gold. However, this is only an idea, the market is impermanent, and the price is not fixed. The actual price must be consulted by the people of the cities and the giants of the industry before it can be obtained.
