6-BROMO-2-(PYRIDIN-2-YL)QUINOLINE

6-Bromo-2- (pyridine-2-yl) quinoline, this is an organic compound. Its molecule contains a quinoline parent nucleus, and quinoline is formed by fusing a benzene ring with a pyridine ring. There is a pyridine-2-group at position 2 of quinoline, and a bromine atom is introduced at position 6 of quinoline.
Looking at its structure, the quinoline parent nucleus endows the compound with a rigid planar structure, which has a great influence on the molecular conjugation system and the distribution of electron clouds, giving it unique physical and chemical properties. As a nitrogen-containing heterocycle, the lone pair of electrons on the nitrogen atom can participate in the chemical reaction, which makes the compound have certain alkalinity and coordination ability, and can form complexes with metal ions, etc., which are widely used in the fields of catalysis and materials science. Bromine atom is an active substituent. Due to the large electronegativity of bromine atom, it can make the connected carbon atom partially positively charged, vulnerable to nucleophilic attack, and then nucleophilic substitution reaction occurs. It is often used as a reaction check point in organic synthesis to construct various derivatives and expand the structural diversity and functional characteristics of the compound.
The unique structure of this compound has caused it to attract attention in many fields such as medicinal chemistry, organic synthesis chemistry, and materials science. In drug development, rigid planar structures with nitrogen-containing heterocycles and halogen atoms may allow them to exhibit high affinity and biological activity for specific biological targets; in the field of organic synthesis, as a key intermediate, bromine atoms and pyridyl groups are used to react to construct complex organic molecules; in the field of materials science, their structural characteristics may endow materials with unique optical and electrical properties, such as for the preparation of luminescent materials, semiconductor materials, etc.

6-Bromo-2- (pyridine-2-yl) quinoline is a valuable compound in the field of organic synthesis. It has a wide range of uses and is often used as a key intermediate in the field of medicinal chemistry. Geinoquinoline and pyridine structural units have unique biological activities and pharmacological properties, and can interact with specific targets in organisms. By introducing bromine atoms, molecules can be further modified, their affinity with targets can be enhanced, or pharmacokinetic properties can be changed, so it is widely used in the development of antibacterial, anti-tumor, anti-inflammatory and other drugs.
In the field of materials science, 6-bromo-2- (pyridine-2-yl) quinoline also has outstanding performance. Due to its molecular structure, the material has specific photoelectric properties, which can be used to prepare organic Light Emitting Diodes (OLEDs), organic field effect transistors (OFETs) and other optoelectronic devices. The presence of bromine atoms can adjust the electron cloud distribution of the molecule, affect the fluorescence emission and charge transport properties of the material, and then improve the efficiency and stability of optoelectronic devices.
In addition, in organic synthesis chemistry, it is an important intermediate and participates in many organic reactions. With the activity of bromine atom, other functional groups can be introduced through nucleophilic substitution, coupling and other reactions to construct more complex organic molecules, providing rich strategies for organic synthesis chemists to expand the structural diversity and functional diversity of organic compounds.

To prepare 6-bromo-2- (pyridine-2-yl) quinoline, the following ancient method can be used.
First take the appropriate quinoline derivative and use it as the starting material. In the reactor, add an appropriate amount of brominating reagents, such as liquid bromine or N-bromosuccinimide (NBS). If liquid bromine is used, it should be handled with caution because of its activity. It is carried out at low temperature and in the presence of a suitable catalyst. The catalyst is often Lewis acid, such as aluminum trichloride or iron filings. Iron filings can react with bromine to form iron bromide, which can then catalyze the reaction. The aim of this step is to introduce the 6-position quinoline into the bromine atom to generate a 6-bromoquinoline derivative.
times to prepare a pyridine-2-based related reagent. It can be started from 2-halogenated pyridine and reacted with metal-organic reagents such as Grignard reagent or lithium reagent to obtain an active pyridine-2-based reagent.
Then, the obtained 6-bromoquinoline derivative is mixed with a pyridine-2-based reagent and reacted in a suitable solvent. Commonly used solvents include tetrahydrofuran, ether and other aprotic solvents, which are stable to metal reagents and can dissolve the reactants. The reaction needs to be carried out under the protection of appropriate temperature and inert gas to avoid the reaction of metal reagents with water and oxygen in the air. After the 2-position nucleophilic substitution of 6-bromoquinoline by metal reagents, 6-bromo-2- (pyridine-2-yl) quinoline is obtained.
After the reaction is completed, the product needs to be separated and purified. First, the conventional extraction method is used to extract with an organic solvent and an aqueous phase to enrich the product in the organic phase. Then by column chromatography, appropriate silica gel column and eluent were selected to separate the product from impurities, and finally purified 6-bromo-2-quinoline was obtained.

6-Bromo-2- (pyridine-2-yl) quinoline is a kind of organic compound. Its physical properties are worth exploring and have important uses in many chemical fields.
In terms of its appearance, under room temperature, it is mostly in a solid state. As for the color, it is usually white to light yellow powder. Due to the arrangement of atoms and electron cloud distribution in the molecular structure, there is a specific pattern of light reflection and absorption, so this color state appears.
Talking about the melting point, it has been experimentally determined to be about [specific melting point value] degrees Celsius. The level of melting point is closely related to the intermolecular forces. There are interactions such as van der Waals force and hydrogen bond between the molecules of this compound, so that the molecules are arranged in an orderly manner. It takes a specific energy to destroy this arrangement and melt into a liquid state, so it has this melting point.
Its solubility is also a key property. It has good solubility in common organic solvents such as dichloromethane and chloroform. Due to the principle of "similar miscibility", the molecular structure of the compound has similar polarity to these organic solvents, so it can be mixed with each other. In water, the solubility is poor, because the polarity of water molecules is strong, and it does not match the intermolecular force of the compound, making it difficult to form a stable dispersion system. < Br >
And its density also has characteristics, about [specific density value] g/cm3, this density value is related to the type of atoms and the way of molecular packing, reflecting the characteristics of its microstructure.
Furthermore, this compound has certain stability and can be stored for a long time under conventional conditions. In case of high temperature, strong oxidant or specific catalyst, its structure will also change, triggering various chemical reactions, which are all due to the chemical activities of bromine atoms, pyridyl groups and quinoline rings in its molecular structure.
In summary, the physical properties of 6-bromo-2- (pyridine-2-yl) quinoline, such as appearance, melting point, solubility, density and stability, are determined by its molecular structure, and play a key role in its reactivity and application in the fields of organic synthesis and medicinal chemistry.

Today I have a question, what is the market price of 6 - BROMO - 2 - (PYRIDIN - 2 - YL) QUINOLINE. This is a specific compound in the field of chemistry, and it is quite complicated to know its price.
Looking at the example of "Tiangong Kaiwu" in the past, the book records all kinds of process materials, but there were no such fine chemical compounds at that time. The price of this compound is primarily due to its difficulty in preparation. If complicated steps and rare raw materials are required to prepare, the price must be high.
The price of raw materials is the main reason. If the synthesis requires rare and expensive starting materials, or the price of the reagents used is high, the cost will increase, resulting in high market prices. The simplicity of the preparation process is also key. If there are many steps and harsh conditions, high technology and equipment are required, and the cost rises, the price will also follow.
Furthermore, market supply and demand also affect its price. If there are many applicants, but the output is limited, the price will rise; if the demand is low, the supply exceeds the demand, the price will decline. And the use of this compound is also important. If used in high-end pharmaceutical research and development, cutting-edge material science, due to special demand, the price may not be low.
In addition, different suppliers and purity grades have different prices. High purity is difficult to prepare, and the price is higher. However, there is no exact data today, and it is difficult to determine its specific market price. It is necessary to comprehensively consider various factors to know its approximate price range.