What are the physical properties of 5-Hydroxyquinoline?

5-Hydroxyquinoline is a kind of organic compound. It has specific physical properties and is now described in detail by you.

Looking at its form, under normal conditions, 5-hydroxyquinoline is a light yellow to brown crystalline powder. When placed in sunlight, it has a slight luster and shimmering, fine and uniform.

When it comes to the melting point, it is about 157-160 ° C. When the temperature gradually rises to the melting point, the substance slowly melts from the solid state into a liquid state, like ice disappearing in the warm sun, and the process is smooth and orderly.

As for the boiling point, it is about 306 ° C. When the temperature reaches this boiling point, 5-hydroxyquinoline is converted from liquid to gaseous state, and rises up like a cloud.

In terms of solubility, 5-hydroxyquinoline is slightly soluble in water, which seems to be rejected in water. It can only be slightly melted with water, but it can be soluble in organic solvents such as ethanol, ether, and chloroform. In ethanol, it can be rapidly dispersed, making the solution uniform, just like a fish entering a Wang Yang, and it blends seamlessly.

Although its density is not comparable with exact ancient books, it has a certain value according to scientific measurements today, which makes it have specific behavior in various reactions and applications. The color, state, melting and boiling point, and solubility of 5-hydroxyquinoline make it unique in various fields of chemistry, such as organic synthesis, drug research and development, etc., just like good materials in craftsmen, each does its best to play an important role.

What are the chemical properties of 5-Hydroxyquinoline?

5-Hydroxyquinoline is an organic compound. Its properties are specific and have many chemical properties.

First of all, its acidity and alkalinity. The hydroxyl group of 5-hydroxyquinoline can release protons, so it is somewhat acidic. However, its quinoline ring is weakly basic, and it can be combined with protons because the nitrogen atom does not share an electron pair. This acid-base amphoteric makes it in different acid-base environments, either acidic dissociation or basic binding protons, and its behavior is variable.

times and redox. In its structure, hydroxyl groups are easily oxidized and can be converted into oxidation products such as quinones. And quinoline rings may also be oxidized when they encounter strong oxidants, causing structural changes. At the same time, if 5-hydroxyquinoline encounters a suitable reducing agent, or can obtain electrons, it is reduced, but the specific reduction product depends on the reaction conditions and the reducing agent used.

The other is coordination. The nitrogen atom and the oxygen atom of 5-hydroxyquinoline have no shared electron pair, which can be used as a ligand to coordinate with metal ions. It can form complexes with diverse structures, and this coordination ability is of great significance in many fields, such as catalysis and materials science. Due to the properties of the formed complexes, they are often very different from the ligands and metal ions alone, or have unique optical, electrical, magnetic and other properties.

The hydrogen atom on the quinoline ring can be replaced by other groups under appropriate conditions. Electrophilic substitution reactions mostly occur in positions with higher electron cloud density. Hydroxyl groups are the power supply groups, which can increase the density of adjacent and para-electron clouds, making them more vulnerable to electrophilic attack, and then generate corresponding substitution products.

5-hydroxyquinoline has rich chemical properties and plays an important role in many fields such as organic synthesis, pharmaceutical chemistry, and materials science. It is an important object of chemists' investigation.

Where is 5-Hydroxyquinoline used?

5-Hydroxyquinoline is used in the fields of chemical industry, medicine and materials.

In the field of chemical industry, it is often used as a chelating agent for metal ions. Due to the characteristics of hydroxyl groups and quinoline rings in the molecular structure, it can complex with a variety of metal ions to form stable chelates. This property is of great significance in the separation, purification and analysis of metal ions. For example, in the extraction of certain rare metals in ores, 5-hydroxyquinoline can selectively bind to target metal ions, helping to separate it from complex mixtures and improve extraction efficiency and purity.

In the field of medicine, 5-hydroxyquinoline also has its functions. It has certain antibacterial and anti-inflammatory activities. Studies have shown that it has inhibitory effects on the growth of some bacteria and fungi, or can be used to develop new antibacterial drugs. And it is used as a key intermediate in the synthesis of some drugs. After chemical modification, many compounds with different pharmacological activities can be derived, providing a broad space for the creation of new drugs.

In the field of materials, 5-hydroxyquinoline can be used to prepare functional materials. For example, in organic electroluminescent materials, it can participate in the construction of luminescent systems, improve the luminescent properties of materials, enhance luminous efficiency and stability, and may have potential applications in display technology. It can also be used to prepare sensor materials with recognition function for specific substances, and by means of their specific binding to the target, sensitive detection of specific substances can be achieved.

What is the preparation method of 5-Hydroxyquinoline?

5 - Hydroxyquinoline is also a way to transform things. The way to do it is also an ancient way.

One method can be obtained from the original of 5-nitroquinoline. Take 5-nitroquinoline first, put it in the appropriate reactor, and take the original of the original, such as the combination of powder and acid. With the help of the original powder and the medium of acid and the medium of acid reaction, the two are combined to make the nitro group in the 5-nitroquinoline. The reverse, the need to control the degree, should be in the low degree, not high, not low. High-level reaction is strong, to control; low-level reaction, lasting for a long time. After the reaction, the method of extraction, crystallization, etc. is used to obtain 5-quinolinol.

Another method starts with 8-quinolinol. First make it nitrified and reversed to get 5-nitro-8-quinolinol. In this step, the nitrification of the compound is used, such as the mixed acid of nitric acid and sulfuric acid. The acidity and acidity of the reaction environment need to be carefully controlled before the nitro group can be replaced at the 5-position of 8-quinolinol. In addition, the original step is to go through the original step, and the nitro group of 5-nitro-8-quinoline can also be used in the original system such as powdered acid. The original reaction is completed, and the original reaction is applied in the same way, and the product of 5-quinoline is used.

There are other raw materials for different phases, such as multi-step synthesis and anti-reaction. First, the method of synthesis is the basic framework of quinoline, and then the group is introduced into its 5 positions. In this way, it is necessary to follow the principle of transformation, and the reasonable reverse way is to follow, and the reverse way is to be done in sequence, such as substitution, addition, elimination, etc. Each step of the reaction requires the injection of the reaction parts, the catalysis of the reaction, etc., to ensure the reaction efficiency and improve the efficiency of the object.

What to pay attention to when using 5-Hydroxyquinoline

5-Hydroxyquinoline is an organic compound. When using it, many matters must be observed.

First, it is related to toxicity. This substance is toxic to a certain extent. When operating, be sure to take good protection. Wear protective clothing, gloves and goggles, and beware of skin contact, inhalation and accidental ingestion. If you accidentally contact it, rinse it with a lot of water immediately, and seek medical treatment if necessary.

Second, about storage. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. Because of its flammability, it can be burned in case of open flames and hot topics, so it needs to be stored separately from oxidants, and it must not be mixed with storage to prevent dangerous reactions.

Third, the use environment is also exquisite. It needs to be operated in a fume hood to ensure air circulation, reduce its concentration in the air, and reduce the harm to the human body. At the same time, the equipment used should be grounded to prevent static electricity from causing fires.

Fourth, the experimental operation should be rigorous. Precisely weigh and measure, strictly follow the experimental procedures, and do not change the steps and dosage without authorization. After use, properly dispose of the remaining drugs and waste, and do not discard them at will. They should be centrally disposed of according to regulations to prevent environmental pollution.

All precautions for the use of 5-hydroxyquinoline should be kept in mind and done with caution to ensure safety and smooth experiment.