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5-Chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1, what is the chemical structure of 2-dihydroquinoline-3-carboxamide?
This is the name of 5-chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-formamide. To clarify its chemical structure, let me tell you in detail.
This compound belongs to quinoline derivatives. According to its name, it can be seen that the structure contains a quinoline parent nucleus. The quinoline parent nucleus is a nitrogen-containing heterocyclic ring, which is formed by fusing a benzene ring with a pyridine ring.
"1,2-dihydro" indicates that the double bond between the 1 and 2 positions of the quinoline parent nucleus is hydrogenated, and two degrees of unsaturation are missing. "5-chloro" indicates that there is a chlorine atom substitution at the 5 position of the quinoline parent nucleus. "4-hydroxyl" refers to the 4 position of the parent nucleus with a hydroxyl group. "1-methyl" means that there is a methyl substitution at the 1 position. "2-oxo" Table 2 is a carbonyl oxygen atom.
Look at "N-ethyl-N-phenyl-3-formamide" again, this is the 3-position formyl group of the parent nucleus connected to ethyl and phenyl on the nitrogen atom. That is, the 3-position carbonyl group is connected to the nitrogen-containing atom group to form an amide structure, and the nitrogen atom is connected to ethyl and phenyl at the same time.
In summary, the chemical structure of this compound is formed by the quinoline parent nucleus modified by multiple substitutions, and contains chlorine, hydroxyl, methyl, carbonyl and specific amide substituents and other functional groups. Each part is connected in an orderly manner by name to form a unique chemical structure.
5-Chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1, what are the main uses of 2-dihydroquinoline-3-carboxamide?
5-Chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-formamide, this material is extraordinary, has a wide range of uses, and has important functions in many fields such as medicine and agriculture.
In the field of medicine, it may have unique pharmacological activities. It can be used as a key intermediate for drug research and development. After ingenious chemical modification and synthesis, new specific drugs are expected to be born. For example, according to the physiological mechanism involved in a specific disease, by virtue of its structural characteristics, the design of therapeutic drugs that fit it, or act on key targets, regulate biological signaling pathways, and have potential significance for disease treatment.
In the field of agriculture, it may play a role in plant protection. Or with bactericidal, antiviral and other properties, it can be developed as a new type of pesticide to protect crops from pests and diseases, improve crop yield and quality, and help the stable development of agriculture. And because of its unique chemical structure, or it shows good degradability in the environment, reducing the long-term impact on the ecological environment is in line with the needs of modern agricultural green development.
In the field of materials science, it may also hold potential. Or by relying on its own structure to endow materials with special properties, such as adding to specific polymer materials, improving the optical, electrical and other properties of materials, providing new opportunities for the creation of new functional materials and promoting the continuous advancement of the field of materials science.
5-Chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1, what is 2-dihydroquinoline-3-carboxamide synthesis method?
The synthesis of 5-chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-formamide is a key research in the field of organic synthesis. This compound has a unique structure and the synthesis path is also quite complex and challenging.
Many talented people in the past have studied the synthesis of quinoline compounds. However, for this specific structure of 5-chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-formamide, its synthesis requires delicate design and careful operation.
Common starting materials, or aniline derivatives with suitable substituents and ethyl acetoacetate compounds containing chlorine can be selected. In the first step, aniline derivatives can be reacted with acylating reagents to obtain corresponding amide intermediates. In this step, the reaction temperature, time and the ratio of reactants need to be carefully adjusted to ensure the smooth progress of the reaction and obtain a higher yield.
In the next step, the obtained amide intermediate and chlorine-containing ethyl acetoacetate are catalyzed by a base for condensation reaction. The choice of bases is crucial, such as inorganic bases such as potassium carbonate and sodium carbonate, or organic bases such as sodium alkoxide, which need to be considered in detail according to the specific reaction conditions. This condensation reaction may generate a preliminary quinoline ring skeleton, but the structure at this time may not fully fit the target product.
Subsequently, the preliminary quinoline ring products are modified by hydroxylation and methylation. Hydroxylation can be achieved by a suitable nucleophilic substitution reaction. Appropriate hydroxylating reagents are selected and operated under appropriate solvents and reaction conditions. Methylation reactions can be completed by methylating reagents such as iodomethane in the presence of bases.
Furthermore, the introduction of chlorine atoms at specific positions can be achieved by halogenation reactions. The selection of halogenating reagents and the control of the reaction environment are all related to the location and efficiency of the introduction of chlorine atoms.
Finally, after reacting with ethylamine, N-ethyl group is introduced to complete the total synthesis of 5-chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-formamide. After each step of the reaction, fine operations such as separation and purification, such as column chromatography and recrystallization, are required to ensure the purity of the product and lay a good foundation for subsequent reactions. In this way, the target compound can be obtained after multiple steps of carefully designed and operated reactions.
5-Chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1, what are the physical properties of 2-dihydroquinoline-3-carboxamide?
5-Chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-formamide is an organic compound. Its physical properties are quite important and have a great impact on its application in many fields.
Looking at its properties, at room temperature and pressure, this compound may be a solid, but the exact shape needs to be determined by experiments. In terms of color, if there is no impurity interference, or it is white to light yellow, because many organic compounds with similar structures are mostly of this color. The melting point of
is one of the key physical properties. The melting point of this compound may be in a specific temperature range, which is the critical temperature for solid-state to liquid-state. Determination of the melting point helps to distinguish its purity and structural stability. After experimental determination, accurate melting point values can be obtained, providing an important basis for its identification and application.
The boiling point cannot be ignored either. The boiling point is the temperature at which the compound transitions from liquid to gaseous state. The boiling point of this compound may be quite high due to its strong intermolecular forces. The high boiling point indicates that at higher temperatures, the compound will vaporize, which is crucial in distillation, separation and other operations.
Solubility is related to the dispersion ability of this compound in different solvents. In organic solvents, such as ethanol, acetone, etc., it may have a certain solubility. Due to the principle of "similar miscibility", its organic structure has good affinity with organic solvents. In water, because it contains more hydrophobic groups, its solubility may be poor, but polar groups such as hydroxyl groups in the molecule may make it slightly soluble.
Density is also a key point in physical properties. Although the exact density value needs to be accurately measured by experiments, it can be inferred that its density may be similar to that of common organic compounds and within a certain range. This value is of great significance in solution preparation, mass and volume conversion, etc.
In addition, the volatility of this compound is relatively low, and the intermolecular force is sufficient to inhibit the molecular escape from the liquid phase due to the relatively stable molecular structure. In terms of odor, if there are no special groups or impurities, or only a weak and indescribable odor.
In summary, the physical properties of 5-chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-formamide are of key significance in its research, production and application, which can help researchers understand its behavioral characteristics and provide important reference for practical operation.
5-Chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1, 2-dihydroquinoline-3-carboxamide what are the precautions during use?
5-Chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-formamide is a rather complex organic compound. During use, many matters need to be paid attention to.
Bear the brunt first, and safety protection must not be slack. This compound may be toxic and irritating. When operating, be fully armed, wear protective clothing, protective gloves and goggles to prevent direct contact with skin and eyes. In case of inadvertent contact, rinse with plenty of water immediately and seek medical attention in time according to the specific conditions. At the same time, the operation should be carried out in a well-ventilated place, or with the help of ventilation equipment, to avoid inhaling its dust or volatile gaseous substances, in order to prevent damage to the respiratory tract.
Furthermore, storage also needs to be paid attention to. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Due to its chemical properties or instability, it should be stored separately from oxidants, acids, bases, etc., and should not be mixed to prevent dangerous chemical reactions.
In the process of taking and weighing, precise operation is required. Due to its complex structure and unique chemical properties, the dosage is slightly deviated, which may greatly affect the experimental results or reaction process. After taking it, be sure to seal the container in time to prevent it from getting wet, oxidizing or reacting with other components in the air.
In addition, the user should have a detailed understanding of the properties and reaction mechanism of the compound. When participating in a chemical reaction, fully consider the possible reaction path and side reactions, and formulate coping strategies in advance to ensure the smooth progress of the experiment or production process and avoid the occurrence of unexpected situations. In short, the use of this compound must be rigorous and meticulous, and the relevant operating procedures and safety guidelines must be strictly followed.