5-Amino-3-chloroisoquinoline

5-Amino-3-bromo isopyridinecarboxylic acid is an important organic compound with wide applications in many fields.
It is often a key intermediate in the field of medicinal chemistry. Due to its special nitrogen, bromine atom and carboxyl structure, it endows the molecule with unique chemical activity and spatial configuration. By means of organic synthesis, it can be integrated into the molecular framework of drugs, which can significantly improve the physicochemical properties, biological activities and pharmacokinetic properties of drugs. For example, it can optimize the lipid solubility of drugs, enhance their transmembrane ability, and make it easier for drugs to reach their targets; it can also adjust the charge distribution of molecules, improve the interaction with biomacromolecules, and improve the affinity and selectivity of drugs to specific disease-related targets, laying the foundation for the development of new high-efficiency and low-toxicity drugs.
In the field of materials science, 5-amino-3-bromoisopyridine carboxylic acid also has important applications. Due to its good coordination ability, it can form stable complexes with a variety of metal ions. These complexes are excellent in luminescent materials, catalytic materials, etc. For example, as a luminescent material, its complexes can emit specific wavelengths of light under specific conditions, which can be used to prepare organic Light Emitting Diode (OLED) and other optoelectronic devices, bringing new breakthroughs in display technology and lighting fields; in terms of catalytic materials, its metal complexes can efficiently catalyze specific chemical reactions, improve reaction efficiency and selectivity, and are of great significance in the organic synthesis industry.
In the field of agricultural chemistry, this compound can be used to develop new pesticides. With its unique chemical structure, it can interact with specific biomacromolecules in pests or pathogens, interfering with their normal physiological metabolic processes, thus achieving insecticidal and bactericidal effects. And compared with traditional pesticides, pesticides developed based on 5-amino-3-bromoisopyridine carboxylic acid may have higher biological activity and environmental friendliness, reducing the negative impact on the ecological environment.

To prepare 5-amino-3-bromo isocoumarin, there are many methods, each of which is ingenious.
First, you can start from a suitable aromatic compound. First, introduce bromine atoms in a delicate way. In this step, you need to choose suitable brominating reagents and conditions to make the bromine atoms fall precisely in the desired position, or use liquid bromine to react at a specific temperature and time with the assistance of a catalyst, or use N-bromosuccinimide (NBS) under the action of light or initiator. Then, after a series of transformations, try to connect the amino group. Or through the process of nitro reduction, the nitro group is first introduced, and then the nitro group is introduced into the amino group by iron powder, hydrochloric acid and other systems, or by catalytic hydrogenation. This process needs to pay attention to the control of the reaction conditions to avoid side reactions.
Second, it can be modified by a compound containing a coumarin skeleton. First modify the coumarin structure to introduce the functional group precursors required by bromine atoms and amino groups. For example, by using nucleophilic substitution reaction, a group that can be converted into an amino group is introduced into a specific position of coumarin, and at the same time, bromine atoms are connected at a suitable check point by means of electrophilic substitution. This process requires a precise understanding of the reactivity check point of coumarin, and ingeniously designs the reaction sequence and conditions according to its electron cloud distribution and reaction laws.
Third, the strategy of intramolecular cyclization can also be used. Using chain compounds with suitable functional groups as raw materials, through carefully designed reactions, the molecule is cyclized, and the structure of 5-amino-3-bromo isocoumarin is constructed at the same time. In this process, the reaction conditions need to be precisely regulated to promote the cyclization reaction to proceed efficiently and selectively, and to avoid the formation of other isomers or by-products.
Each method has its own advantages and disadvantages, and it is necessary to choose carefully according to the actual situation, such as the availability of raw materials, the difficulty of reaction, and the purity requirements of the product.

5-Amino-3-bromoisocoumarin is a unique organic compound with several specific physical and chemical properties.
Its properties are mostly solid under normal conditions, which is related to its intermolecular interactions. There are van der Waals forces and hydrogen bonds between molecules, which cause it to be solid at room temperature and pressure.
The melting point is a specific temperature range, which varies slightly due to different purity and experimental conditions. Generally speaking, the melting point characterizes the critical temperature of a substance from solid to liquid state, reflecting the strength of intermolecular forces. 5-Amino-3-bromoisocoumarin has a specific molecular structure and moderate intermolecular forces, which determine its melting point range.
In terms of solubility, it has a certain solubility in organic solvents such as dichloromethane, chloroform, N, N-dimethylformamide (DMF). The organic solvent molecule and 5-amino-3-bromo isocoumarin molecules can form similar miscibility effects, such as van der Waals force, dipole-dipole interaction, etc., to help them dissolve. However, the solubility in water is relatively low, because its molecules are not highly hydrophilic, it is difficult to form strong interactions between water molecules and the compound molecules to overcome the intermolecular forces of the compound.
5-Amino-3-bromo isocoumarin contains amino and bromine atoms and isocoumarin structures, which give it certain chemical activity. Amino groups are nucleophilic and can participate in nucleophilic substitution, condensation and other reactions; bromine atoms can be introduced into other functional groups through substitution reactions; isocoumarin structure gives it the possibility of cyclization, ring opening and other reactions under specific conditions. These chemical properties make it widely used in the field of organic synthesis, and can be used as key intermediates to prepare a variety of organic compounds with biological activity or special functions.

In today's market, the price of 5-amino-3-bromo isonicotinic acid varies depending on the quality, quantity, and supply. Its price is about tens to hundreds of dollars per gram. If you ask for a large quantity, or you can negotiate with Jia, you can get a slightly cheaper price.
This substance is widely used in the fields of medicine and chemical industry, and is an essential material for the production of various medicines and fine chemicals, so its price also varies with the needs of the market. If it is of high quality, if you ask for more with less, the price will be high; if it is of slightly inferior quality, if the supply is sufficient and the demand is slow, the price will be flat.
If you want to get a definite price, you can consult drug dealers, chemical manufacturers, or visit the market network of chemical transactions to know the range of the current price for preparation. And the market conditions are ever-changing, and the price is also unstable. If you look at it often, you can get a good price, which is what the industry should pay attention to.

5-Amino-3-bromoisocoumarin is an organic compound. Its storage conditions are crucial and related to the stability and quality of this substance.
First, it needs to be stored in a low temperature environment. It should be placed in the refrigerator at a temperature of about 2-8 ° C. In this way, it can slow down the molecular movement and inhibit the rate of chemical reactions to prevent its deterioration. Low temperature can reduce the molecular activity and reduce the decomposition and polymerization caused by molecular collision, thereby prolonging the shelf life of this substance.
Second, keep it dry. Moisture can cause many compounds to undergo reactions such as hydrolysis, and 5-amino-3-bromoisocoumarin is no exception. It should be stored in a dryer, or a desiccant should be added to the storage container to isolate external water vapor. The desiccant can absorb moisture in the environment, maintain the drying of the storage environment, and avoid the structural damage of the compound due to the presence of water.
Third, it is indispensable to store in the dark. This compound is more sensitive to light. Under light, it is easy to cause photochemical reactions, causing changes in its structure and loss of activity. Therefore, it should be placed in a dark container such as a brown bottle, or stored in a place where light is difficult to shine. The brown bottle can absorb part of the light, reduce the influence of light on the compound, and ensure its stability.
Fourth, sealed storage is also the key. Long-term contact with air, oxygen, carbon dioxide and other components in it, or react with 5-amino-3-bromoisocoumarin. Sealed storage can reduce contact with air, prevent oxidation, carbonation and other reactions, and ensure the purity and quality of the compound.
In summary, 5-amino-3-bromoisocoumarin should be stored at low temperature, dry, protected from light and sealed conditions to ensure its stability for subsequent use.