What is the chemical structure of (4S) -4-ethyl-4-hydroxy-11- {2- [ (1-methylethyl) amino] ethyl} -1H-pyrano [3 ', 4': 6,7] indolizino [1,2-b] quinoline-3,14 (4H, 12H) -dione

(4S) - 4 - ethyl - 4 - hydroxy - 11 - {2 - [ (1 - methylethyl) amino] ethyl} - 1H - pyrano [3 ', 4': 6,7] indolicino [1,2 - b] quinoline - 3,14 (4H, 12H) -dione, which is a complex organic compound. According to its name, its structure can be gradually analyzed according to the system nomenclature.

" (4S) " indicates that the configuration of the compound at the No. 4 carbon atom is S-type, which is a sign of the configuration of the chiral carbon atom. It is related to the arrangement of molecular space and has an important impact on many properties of the compound, such as biological activity and optical activity.

"4-ethyl" is obviously connected to the fourth carbon atom of the main chain with ethyl (-C ² H). The introduction of this alkyl group can change the physical and chemical properties of the molecule, such as solubility and fat solubility. < Br >
"4-Hydroxy", indicating that the fourth carbon atom also has a hydroxyl group (-OH), which is a strongly polar group and can participate in the formation of hydrogen bonds, which plays a role in the water solubility, acidity and alkalinity of the compound and chemical reactivity.

"11 - {2- [ (1-methylethyl) amino] ethyl}", indicating that there is a complex side chain connected at position 11. Among them, "2 - [ (1 - methylethyl) amino] ethyl", (1 - methylethyl) that is, isopropyl (-CH (CH) ³), this side chain structure contains an amino group, the amino group is basic, and can participate in acid-base reactions and other carbonyl-containing groups to form hydrogen bonds or covalent bonds.

"1H-pyrano [3 ', 4': 6,7] indolicino [1,2 - b] quinoline-3,14 (4H, 12H) -dione", which is the core parent structure of the compound. It is formed by fusing a pyran ring, an indolicino ring and a quinoline ring, and each has a carbonyl group (C = O) at the 3rd and 14th positions (in the state of 4H and 12H, respectively). This fused ring system endows the compound with a unique conjugate structure, which affects its electron cloud distribution, stability and spectral properties.

In summary, the chemical structure of this compound is composed of carbon atoms of specific configurations, various substituents and complex fused ring parent nuclei. The interactions of each part jointly determine the physical, chemical and biological activities of the compound.

What are the physical properties of (4S) -4-ethyl-4-hydroxy-11- {2- [ (1-methylethyl) amino] ethyl} -1H-pyrano [3 ', 4': 6,7] indolizino [1,2-b] quinoline-3,14 (4H, 12H) -dione

(4S) -4-ethyl-4-hydroxy-11 - {2 - [ (1-methylethyl) amino] ethyl} -1H -pyrano [3 ', 4': 6,7] indolo [1,2 - b] quinoline-3,14 (4H, 12H) -dione, which is a rather complex organic compound. Looking at its structure, it is composed of a combination of many specific groups. Its physical properties, when first discussed in terms of appearance, have not been described in detail, or it is a solid state, white or off-white powder, because many complex organic compounds of the same type are often like this.

When it comes to melting point, such complex organic compounds may have a high melting point due to complex intermolecular forces, but the specific value needs to be determined by accurate experiments. Its solubility in water or solubility is very small. Although its molecular structure contains polar groups such as hydroxyl groups, it is composed of a large cyclic structure and non-polar alkyl groups as a whole, which makes it insoluble in polar solvent water. In organic solvents, such as dichloromethane, chloroform and other non-polar or weakly polar solvents, the solubility may be relatively high. Due to the similar miscibility principle, its non-polar part can be well miscible with organic solvents.

In addition, the density of this compound is also an important physical property, but the exact value is difficult to infer out of thin air and needs to be measured experimentally. However, according to its structure and similar compound characteristics, the density may be within the range of common organic compounds, which is roughly different from the density of water, or the corresponding value may be presented due to the type and close arrangement of atoms in the molecule.

The physical properties of this compound have a profound impact on its application in chemical synthesis, drug development and other fields, and it needs to be accurately determined by experiments to clarify its characteristics and lay the foundation for subsequent research and application.

What is the synthesis method of (4S) -4-ethyl-4-hydroxy-11- {2- [ (1-methylethyl) amino] ethyl} -1H-pyrano [3 ', 4': 6,7] indolizino [1,2-b] quinoline-3,14 (4H, 12H) -dione

The synthesis of (4S) -4-ethyl-4-hydroxy-11 - {2 - [ (1-methylethyl) amino] ethyl} -1H-pyrano [3 ', 4': 6,7] indolicino [1,2 - b] quinoline-3,14 (4H, 12H) -dione, including the synthesis of this compound, requires multiple steps of delicate reaction.

The choice of starting material is crucial. It is often based on derivatives such as indolicidine and quinoline with corresponding structures. In the first step, it may be necessary to protect or activate the activity check point of the starting material. For example, if the starting material contains reactive hydroxyl groups, amino groups, etc., suitable protective groups, such as silicon ethers to protect hydroxyl groups, amides to protect amino groups, are required to prevent them from reacting improperly in subsequent reactions.

Then, by means of condensation reaction, the fragments containing ethyl groups and hydroxyl groups are connected to the indolicino-quinoline skeleton. This condensation reaction may be carried out by using a condensation agent, such as dicyclohexyl carbodiimide (DCC), 1 - (3-dimethylaminopropyl) - 3-ethyl carbodiimide hydrochloride (EDCI), etc., to promote the reaction to proceed efficiently.

After the skeleton is initially formed, the {2 - [ (1-methylethyl) amino] ethyl} fragment of position 11 is introduced. This step may be achieved by nucleophilic substitution. The halogenated ethyl derivative is reacted with isopropylamine first to obtain the corresponding aminoethyl compound, and then reacted with the formed skeleton under basic conditions to realize the introduction of the fragment. < Br >
During the reaction process, the reaction conditions at each step, such as temperature, reaction time, and solvent selection, need to be precisely controlled. If the temperature is too high or too low, the reaction yield can be low, or by-products can be formed. The polarity and solubility of the solvent also have a significant impact on the reaction process.

Finally, the product is deprotected to obtain the target product (4S) -4-ethyl-4-hydroxy-11 - {2 - [ (1-methylethyl) amino] ethyl} -1H -pyrano [3 ', 4': 6,7] indolicino [1,2-b] quinoline-3,14 (4H, 12H) -dione. The product needs to be purified by recrystallization, column chromatography, etc. to achieve higher purity.

(4S) -4-ethyl-4-hydroxy-11- {2- [ (1-methylethyl) amino] ethyl} -1H-pyrano [3 ', 4': 6,7] indolizino [1,2-b] quinoline-3,14 (4H, 12H) -dione is used in which fields

(The name of this compound is very long and complex, and its related applications are rarely found in ancient books. I try to use today's understanding and describe it in the language of antiquarians.)

This " (4S) -4-ethyl-4-hydroxy-11- {2- [ (1-methylethyl) amino] ethyl} -1H-pyrano [3 ', 4': 6,7] indolizino [1,2 - b] quinoline - 3,14 (4H, 12H) -dione", in the field of medicine, or has potential use. Looking at modern medical research, such complex organic compounds are often the basis for exploring new drugs. Or they can use their unique molecular structure to act on specific targets in the human body to treat various diseases.

In the field of chemical synthesis, this compound can be the key to the exploration of synthetic paths. Its complex structure requires quite strict synthesis techniques. If its synthesis method can be understood, it may promote the further development of organic synthesis, paving the way for the creation of more novel and useful compounds.

In the study of life sciences, such compounds may be used to explore the interactions between molecules in living organisms. Observing their combination with biological macromolecules and understanding their impact on biological processes will help to reveal the mysteries of life and contribute to the development of life science in the future. Although ancient books did not contain the name and use of such compounds, their potential value in many fields should not be underestimated.

What is the market outlook for (4S) -4-ethyl-4-hydroxy-11- {2- [ (1-methylethyl) amino] ethyl} -1H-pyrano [3 ', 4': 6,7] indolizino [1,2-b] quinoline-3,14 (4H, 12H) -dione?

There is a product named (4S) -4-ethyl-4-hydroxy-11- {2- [ (1-methylethyl) amino] ethyl} -1H-pyrano [3 ', 4': 6,7] indolizino [1,2-b] quinoline-3,14 (4H, 12H) -dione. The market prospect of this product is quite attractive.

In today's field of medicine and chemical industry, the emergence of new compounds is often an opportunity for development. This compound has a unique structure or has different chemical activities and pharmacological properties. In the pharmaceutical market, if it can exhibit significant pharmacological activities, such as anti-inflammatory and anti-tumor, it must attract the attention of pharmaceutical companies and is expected to be developed into innovative drugs. However, the road to new drug research and development is full of thorns, and it needs to go through multiple rounds of rigorous tests, from cell experiments, animal experiments, to human clinical trials, layer by layer, before it can be put on the market.

In the chemical industry, its unique structure may make it an excellent material intermediate, which can be used to synthesize high-performance materials, such as special plastics, fibers, etc. However, chemical applications also need to consider the production cost and the difficulty of the production process. If the production process is complex and the cost is high, it may be difficult to promote on a large scale.

Furthermore, market competition is also the key. The number of similar or alternative products affects its market prospects. If this compound has unique advantages and stands out, it can occupy a place in the market. However, the current market is constantly changing, and only by continuously improving technology, reducing costs, and improving quality can we follow the trend and open up a vast market space.