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What is the chemical structure of (4S) -4,11-diethyl-4-hydroxy-1H-pyrano [3 ', 4': 6,7] indolo [1,2-b] quinoline-3,14 (4H, 12H) -dione?
The compound is named (4S) -4,11-diisopropyl-4-pentyl-1H-pyrrolido [3 ', 4': 6,7] indolo [1,2-b] furozan-3,14 (4H, 12H) -dione. Its chemical structure consists of several parts:
1. ** Core skeleton **: Pyrrozo [3 ', 4': 6,7] indolo [1,2-b] furozan as the core, this part is the key structure of the whole molecule, fusing the structural characteristics of pyrrole, indole and furozan, giving the compound unique electronic properties and spatial configuration. Among them, the pyrrole ring and the indole ring are connected by a specific union ring, which determines the molecular planarity and the range of the conjugated system; the existence of the furozan ring further enriches the structural complexity, because it contains nitrogen and oxygen heteroatoms, which affects the electron cloud distribution and reactivity of the molecule.
2. ** Substituent **: On the basis of the core skeleton, the 4 and 11 positions are connected to diisopropyl, and the 4 positions are also connected with amyl. Isopropyl and amyl, as alkyl substituents, have electron-giving effects, which can change the electron cloud density of the core skeleton and affect its chemical properties. For example, the steric hindrance of alkyl groups will affect the intermolecular interactions and the proximity of reagents in chemical reactions; at the same time, alkyl groups of different lengths and structures also have significant effects on the physical properties of compounds, such as solubility, melting point, boiling point, etc.
3. ** Diketone structure **: The diketone structure at position 3,14 is an important activity check point. Carbonyl (C = O) has strong polarity, which makes the electron cloud density in this area high, prone to nucleophilic addition reactions, can react with active hydrogen or nucleophilic reagents, and participate in various chemical reaction pathways, thereby deriving a variety of chemical products, which have potential application value in the fields of organic synthesis and drug development. < Br >
This compound has a unique structure and the synergistic effect of multiple structural fragments endows it with rich chemical properties and potential applications.
What are the main pharmacological activities of (4S) -4,11-diethyl-4-hydroxy-1H-pyrano [3 ', 4': 6,7] indolo [1,2-b] quinoline-3,14 (4H, 12H) -dione?
(4S) -4,11-diisopropyl-4-pentyl-1H-pyrrolido [3 ', 4': 6,7] indolo [1,2-b] pyrazine-3,14 (4H, 12H) -dione, this compound has a variety of important pharmacological activities.
Its main pharmacological activities are as follows:
1. ** Anti-tumor activity **: Compounds of this structure have shown inhibitory effects on tumor cell growth in some studies. It can interfere with the proliferation and survival of tumor cells by affecting key metabolic pathways of tumor cells. For example, it can act on the signaling pathway of certain tumor cells, blocking the signaling that promotes abnormal cell proliferation, thereby inhibiting the division and growth of tumor cells, and is expected to become a potential direction for the development of anti-tumor drugs.
2. ** Neuroregulatory activity **: Some compounds containing structures similar to pyrroloindole and pyrazine have been found to have regulatory effects on the nervous system. It may affect the release and uptake of neurotransmitters, regulate the signaling between nerve cells, and have potential application value in the treatment of neurological-related diseases, such as Parkinson's disease, Alzheimer's disease, etc., and may improve the symptoms of neurological dysfunction in patients.
3. Antibacterial activity: In some experiments, related structural analogs have shown certain antibacterial ability. They may inhibit the growth and reproduction of bacteria by destroying the cell wall and cell membrane structure of bacteria, or interfering with key physiological processes such as protein synthesis and nucleic acid metabolism of bacteria, and have inhibitory effects on a variety of common pathogenic bacteria, providing ideas for the development of new antibacterial drugs.
What are the synthesis methods of (4S) -4,11-diethyl-4-hydroxy-1H-pyrano [3 ', 4': 6,7] indolo [1,2-b] quinoline-3,14 (4H, 12H) -dione?
In "Tiangong Kaiwu", there are many ways to synthesize (4S) -4,11-diisopropyl-4-pentyl-1H-pyrrolo [3 ', 4': 6,7] indolo [1,2-b] pyrazine-3,14 (4H, 12H) -dione.
First, the molecular structure can be constructed one by one from the basic raw materials through multiple delicate chemical reactions. First take the appropriate starting compound, through a specific substitution reaction, isopropyl, amyl and other groups are introduced. This process requires precise control of the reaction conditions, such as temperature, pH and catalyst dosage, to ensure the accuracy of the substitution check point.
Second, for the formation of heterocyclic structures such as pyrrole and indole, cyclization can be used. Through ingenious design of the structure of the reactants, under appropriate reaction reagents and conditions, the intramolecular cyclization is promoted, and the key heterocyclic skeleton is established. During this period, attention should be paid to the selectivity and yield of the reaction to avoid unnecessary side reactions. < Br >
Third, the formation of diketone structures can often be achieved by oxidation or acylation reactions. According to the specific raw materials and reaction paths, select appropriate oxidizing agents or acylating reagents to achieve accurate synthesis of diketones.
Synthesis of this compound requires chemists to be familiar with the characteristics and laws of various organic reactions, carefully plan the reaction route, and carefully operate each step of the reaction in order to effectively and efficiently prepare the target product.
(4S) -4,11-diethyl-4-hydroxy-1H-pyrano [3 ', 4': 6,7] indolo [1,2-b] quinoline-3,14 (4H, 12H) -dione in which applications?
(4S) -4,11-diisopropyl-4-pentyl-1H-pyrrolo [3 ', 4': 6,7] indolo [1,2-b] pyrazine-3,14 (4H, 12H) -dione, which is used in various fields. In the field of medicine, it may have unique pharmacological activities and can be used as a lead compound to develop new drugs. Due to its special chemical structure, it may be able to closely fit with specific biological targets, affect cell signaling pathways, and then intervene in disease processes. For example, for the development of anti-cancer drugs, it is expected to use its structural properties to precisely target cancer cells with minimal side effects. < Br >
In the field of materials science, it may exhibit specific optoelectronic properties. Due to the presence of a conjugated system in the compound structure, or the material has good charge transport ability, it can be applied to organic semiconductor materials. If used in the manufacture of organic Light Emitting Diode (OLED), it is expected to improve the luminous efficiency and stability of the device, providing a new direction for the development of display technology.
In the field of agriculture, it may also have potential applications. Due to its structural complexity, or its inhibitory or killing effect on specific pests and bacteria, it can be developed as a new type of pesticide. And because it is derived from organic synthesis, it is more environmentally friendly than traditional pesticides, and is conducive to the development of green agriculture.
In summary, (4S) -4,11-diisopropyl-4-pentyl-1H-pyrrole [3 ', 4': 6,7] indolo [1,2-b] pyrazine-3,14 (4H, 12H) -dione has broad application prospects in the fields of medicine, materials science, and agriculture.
What is the market prospect of (4S) -4,11-diethyl-4-hydroxy-1H-pyrano [3 ', 4': 6,7] indolo [1,2-b] quinoline-3,14 (4H, 12H) -dione?
Nowadays, there are (4S) -4,11-diisopropyl-4-fluoro-1H-pyrrole [3 ', 4': 6,7] indolo [1,2-b] furazan-3,14 (4H, 12H) -dione. Its market prospects are as follows:
This compound has a unique structure and contains specific groups such as diisopropyl and fluoro groups. It can be used in the field of pharmaceutical research and development, or due to the strong electronegativity and unique electronic effects of fluorine atoms, it can change the physical and chemical and biological activities of compounds, or become new drug lead compounds. For example, some fluorinated drugs have good lipophilic properties, easily penetrate biofilms, improve bioavailability, and may have potential for the development of anti-cancer and antiviral drugs.
In the field of materials science, its pyrroloindole and fuzan structures may endow materials with special optoelectronic properties. For example, pyrrole derivatives are often used in organic semiconductor materials. The compound may be structurally modified to make a new type of organic optoelectronic material. It is used in organic Light Emitting Diodes, solar cells, etc. Due to its unique structure or special light absorption, emission and charge transport properties.
However, its marketing activities also face challenges. Synthesis of the compound may require complex steps and special reagents, resulting in high production costs. And the research and development of new compounds requires a large number of experiments and strict approval. In the field of medicine, from lead compounds to marketed drugs, it needs to go through long stages such as preclinical research and clinical trials, which is time-consuming and labor-intensive.
But in general, if the synthesis and research and development problems can be overcome, (4S) -4,11-diisopropyl-4-fluoro-1H-pyrrolido [3 ', 4': 6,7] indolo [1,2-b] fuzan-3,14 (4H, 12H) -dione may have broad market prospects in the fields of medicine and materials.