What is the chemical structure of (4α S-cis) -1-Cydopropyl-6-fluoro-1, 4-dihydro-8-methoxy-7- (octahydro-6H-pyrrolo [3,4-b] pyridin-6-y1) -4-oxo-3-quinolinecarboxylic acid

(4α S-cis) -1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7- (octahydro-6H-pyrrolido [3,4-b] pyridine-6-yl) -4-oxo-3-quinoline carboxylic acid, which is an organic compound. Looking at its name, it can be seen that it is composed of many structural fragments.

Its core structure is quinoline carboxylic acid, and there are various substituents at specific positions in the quinoline ring. The first position is connected with a cyclopropyl group, which has a compact structure and certain rigidity, or affects the spatial configuration and physical and chemical properties of the molecule. The sixth position is a fluorine atom, which has high electronegativity and can change the electron cloud distribution of the molecule, affecting its polarity and chemical reactivity. The eighth position is connected to a methoxy group, and the lone pair electrons of the oxygen atom in the methoxy group can participate in the conjugation, which has an effect on the electron cloud density of the molecule.

The octahydro-6H-pyrrolio [3,4-b] pyridine-6-yl at position 7 is a complex nitrogen-containing heterocyclic structure. The existence of this heterocyclic ring enriches the stereochemical characteristics of the molecule, and multiple chiral centers may make the compound stereoselectivity. The carbonyl group (4-oxo) at position 4 is an electron-withdrawing group, which affects the electron cloud distribution and acidity of the molecule.

In summary, the chemical structure of this compound is composed of a quinoline carboxylic acid core skeleton and many specific position substituents. The interaction of each part endows it with unique chemical properties and potential biological activities.

What are the pharmacological effects of (4α S-cis) -1-Cydopropyl-6-fluoro-1, 4-dihydro-8-methoxy-7- (octahydro-6H-pyrrolo [3,4-b] pyridin-6-y1) -4-oxo-3-quinolinecarboxylic acid

(4α S-cis) -1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7- (octahydro-6H-pyrrolido [3,4-b] pyridine-6-yl) -4-oxo-3-quinoline carboxylic acid, which is the name of the chemical substance. As a quinolone antibacterial drug, it plays a key role in the field of medicine.

This drug can interfere with the replication, transcription and repair of bacterial DNA by inhibiting the activity of bacterial DNA rotatase and topoisomerase IV, and then achieve antibacterial effect. In clinical application, it has shown significant antibacterial activity against many Gram-positive and Gram-negative bacteria.

Gram-negative bacteria such as Escherichia coli and Klebsiella pneumoniae, when encountered with this drug, their normal growth and reproduction process will be strongly inhibited. For Gram-positive bacteria such as Streptococcus pneumoniae and Staphylococcus aureus, this drug can also play an effective antibacterial effect.

Its pharmacokinetic properties in vivo are also very important. After oral administration, it can be absorbed relatively quickly, widely distributed in the body, and can achieve effective drug concentrations in multiple tissues and body fluids, which lays a solid foundation for its effective treatment of infectious diseases. Whether it is respiratory tract infections, urinary system infections, or intestinal infections, it is possible to use this drug for treatment, and it can often harvest good curative effects and help patients recover.

What are the clinical applications of (4α S-cis) -1-Cydopropyl-6-fluoro-1, 4-dihydro-8-methoxy-7- (octahydro-6H-pyrrolo [3,4-b] pyridin-6-y1) -4-oxo-3-quinolinecarboxylic acid

(4α S-cis) -1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7- (octahydro-6H-pyrrolido [3,4-b] pyridine-6-yl) -4-oxo-3-quinoline carboxylic acid, this is the name of the chemical substance, and its clinical application is quite extensive.

In the field of antibacterial, this drug can effectively fight many bacteria. For example, Gram-positive and negative bacteria, it can play a significant role. For pneumonia caused by Gram-positive bacteria such as Streptococcus pneumoniae, this drug can inhibit the activity of bacterial DNA rotatase and topoisomerase IV, hinder bacterial DNA replication, transcription and repair, and then achieve bactericidal effect, helping patients relieve lung infection symptoms and improve respiratory status.

In urinary system infections, Gram-negative bacteria such as Escherichia coli are often the culprit. This drug can precisely act on bacteria, kill bacteria, reduce patients' urinary frequency, urgency, urinary pain and other uncomfortable symptoms, and promote urinary system recovery.

Intestinal infections are also its uses. Like dysentery caused by Shigella, this substance can inhibit bacterial growth and reproduction, relieve patients' diarrhea, abdominal pain and other symptoms, and help intestinal function return to normal.

In addition, if skin and soft tissue infections are caused by sensitive bacteria, this medicine can also exert antibacterial and anti-inflammatory effects, promote wound healing, and relieve local symptoms such as redness, swelling, heat, and pain. In conclusion, (4α S-cis) -1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7- (octahydro-6H-pyrrolido [3,4-b] pyridine-6-yl) -4-oxo-3-quinolinecarboxylic acid has important value in the field of clinical antimicrobial therapy and provides an effective means for the treatment of many infectious diseases.

What are the side effects of (4α S-cis) -1-Cydopropyl-6-fluoro-1, 4-dihydro-8-methoxy-7- (octahydro-6H-pyrrolo [3,4-b] pyridin-6-y1) -4-oxo-3-quinolinecarboxylic acid

(4α S-cis) -1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7- (octahydro-6H-pyrrolido [3,4-b] pyridine-6-yl) -4-oxo-3-quinoline carboxylic acid, this is the name of the chemical substance, which is rarely heard by ordinary people. It is mostly used in the field of medicine to make drugs and exert specific pharmacological effects.

The side effects of this substance are related to the safety of the user and cannot be ignored. The first to bear the brunt, it affects the gastrointestinal tract. After taking the medicine, you may feel nausea, there seems to be something stirring in the abdomen, and you want to vomit but not quickly; or you may feel vomiting, and the food in the stomach gushes out; or you may have diarrhea, intestinal rumbling in the abdomen, and frequent toilet use. This is all caused by the drug stimulating the gastrointestinal mucosa, which affects its normal transportation and transportation.

Furthermore, it also has an effect on the central nervous system. After taking the medicine, some people may feel dizzy, unsteady, as if they are in clouds and fog; or they may suffer from headaches, such as the head being pressed by heavy objects, causing unbearable pain; in severe cases, they may even experience insomnia, long nights, tossing and turning, and difficulty falling asleep. This is the reason why the drug interferes with the normal function of the nervous system.

In addition, it may also have side effects on the skin. During the medication, the skin or skin rash, red spots appear on the body, itching is intolerable, scratching, or skin damage; or itching, the whole body or local skin itching is not only, making people restless, this is the manifestation of skin allergic reaction caused by the drug.

In addition, it may affect liver function. Long-term or heavy use may increase the burden on the liver and cause abnormal liver function indicators. Although the symptoms may not be obvious, it is necessary to regularly check liver function to ensure liver health.

The above are all possible side effects of (4α S-cis) -1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7- (octahydro-6H-pyrrolido [3,4-b] pyridine-6-yl) -4-oxo-3-quinoline carboxylic acid. When taking medication, be cautious and pay close attention to physical changes.

What is the preparation method of (4α S-cis) -1-Cydopropyl-6-fluoro-1, 4-dihydro-8-methoxy-7- (octahydro-6H-pyrrolo [3,4-b] pyridin-6-y1) -4-oxo-3-quinolinecarboxylic acid

(4α S-cis) -1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7- (octahydro-6H-pyrrolido [3,4-b] pyridine-6-yl) -4-oxo-3-quinoline carboxylic acid, the method of preparation of this substance has been used in ancient times, but the methods are also different.

Prepared in the past, or followed by chemical synthesis. First, suitable starting materials, such as compounds containing quinoline structure, and reagents with specific substituents, under suitable reaction conditions, make them interact. Taking the cyclopropylation reaction as an example, a suitable cyclopropylation reagent, such as cyclopropyl halide, needs to be selected. Under the catalysis of a base, a nucleophilic substitution reaction occurs with the quinoline precursor containing the active check point to introduce the cyclopropyl group.

As for the introduction of fluorine atoms, the method of nucleophilic substitution or electrophilic fluorination is often used. In the case of nucleophilic substitution, a fluorine-containing nucleophilic reagent is used to replace the corresponding leaving group under specific conditions; in the case of electrofluorophilic fluorination, fluorine atoms are introduced at the appropriate check point of the substrate.

The addition of methoxy groups is achieved, or by the synthesis reaction of haloalkanes and Williamson ethers of phenols A suitable halogenated methane is selected to react with a quinoline derivative with phenolic hydroxyl group in the presence of a base to obtain a methoxy-containing product.

And octahydro-6H-pyrrolido [3,4-b] pyridine-6-yl access, or through multi-step reactions, the parent nucleus of pyrrolido-pyridine is first constructed, and then it is connected to the quinoline position 7 through reduction and substitution.

During the preparation process, the control of reaction conditions is crucial. Temperature, reaction time, and the proportion of reactants are all related to the yield and purity of the product. After each step of the reaction, it is often necessary to separate and purify the product by means of recrystallization, column chromatography, etc., in order to obtain high purity (4α S-cis) -1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7- (octahydro-6H-pyrrolido [3,4-b] pyridine-6-yl) -4-oxo-3-quinoline carboxylic acid. Although the preparation method is complicated, it will be possible to study the details of each step carefully and follow the scientific method.