4-Quinolinecarboxylic acid, 2-(trifluoromethyl)-, ethyl ester

This di- (triethyl) -4 -p-methoxyphenylacetate ethyl ester is an important compound in the field of organic synthesis. Its main uses are many, and in the field of medicinal chemistry, it can be used as a key intermediate to synthesize drugs with specific physiological activities. Due to the structural properties of this compound, it can introduce unique functional groups and spatial configurations to drug molecules, thereby endowing drugs with specific pharmacological effects and pharmacokinetic properties.
In the field of fragrance chemistry, this compound may be able to derive substances with unique flavors and aromas due to its unique chemical structure, so it can be used to prepare fragrances of specific fragrances, adding layers and uniqueness of aroma.
Furthermore, in the field of materials science, this compound can be used as a raw material through specific chemical reactions and processes, or materials with special properties can be prepared. For example, by polymerizing with other monomers, the material may be endowed with unique solubility, thermal stability and mechanical properties.
Because of the specific functional groups in its structure, it can be used as a check point in organic synthesis reactions, participating in various classical organic reactions, such as esterification reactions, nucleophilic substitution reactions, etc., providing a basis for the construction of more complex organic molecular structures, and then expanding its application range in many fields, from the preparation of fine chemicals to the total synthesis of complex natural products, It can be seen and plays an indispensable role.

To prepare ethyl 2 - (triethyl) - 4 - p-methoxybenzoate, the following methods can be followed.
First, p-methoxybenzoic acid is used as the starting material. First, it is esterified with ethanol under the catalysis of concentrated sulfuric acid. This process requires careful temperature control, usually in the state of heating and reflux. After a few hours, ethyl p-methoxybenzoate can be obtained. Then, the product is combined with a halogenated hydrocarbon containing triethyl methyl, in the presence of a strong base such as sodium hydride, in a suitable organic solvent such as tetrahydrofuran, and nucleophilic substitution is performed. In the meantime, it is necessary to pay attention to the anhydrous and anoxic reaction environment. After the reaction is completed, the target product can be obtained after a series of post-treatments, such as extraction, washing, drying, distillation, etc.
Second, p-methoxybenzaldehyde can also be used as the starting material. First, through the Wittig reaction, it interacts with the phosphorus-containing Ylide reagent to introduce a specific carbon chain structure to generate the corresponding olefin derivative. Then the olefin derivative is moderately oxidized and converted into a carboxylic acid, and then esterified with ethanol as in the first step above, and ethyl p-methoxybenzoate can also be obtained. The next step is to react with the halogenated hydrocarbon containing triethyl methyl with the previous method to finally obtain the target compound.
Third, p-methoxyphenol is used as the starting material. First, it is reacted with ethyl haloacetate under alkaline conditions to form ethyl p-methoxyphenoxyacetate. Then triethyl is introduced through Fu-g alkylation reaction. This reaction requires the use of a suitable catalyst such as aluminum trichloride in a suitable reaction solvent such as dichloromethane. After the reaction, after purification, 2- (triethyl) -4 - ethyl p-methoxybenzoate can also be obtained.
The above methods have advantages and disadvantages. In actual preparation, the appropriate method should be carefully selected according to the availability of raw materials, cost, difficulty of reaction conditions and many other factors.

"Tiangong Kaiwu" cloud: di- (triethyl) - 4 - ethyl p-methoxyphenylacetate, this is an organic compound. Its physical and chemical properties are unique, let me come one by one.
Looking at its physical properties, under normal conditions, di- (triethyl) - 4 - ethyl p-methoxyphenylacetate is mostly a colorless to light yellow oily liquid with uniform texture and fluidity. Under light, it can be seen that its luster is soft. Close to the smell, slightly special smell, non-pungent and unpleasant smell, but also has a unique smell, this smell may be related to the molecular structure.
Talking about the boiling point, the boiling point of this compound is quite high, and specific temperature conditions are required to convert from liquid to gaseous state. This is caused by intermolecular forces, such as van der Waals forces, hydrogen bonds, etc., which make the molecules closely connected, requiring more energy to overcome attractive forces and achieve gas-liquid conversion.
As for solubility, di- (triethyl) - 4 - ethyl p-methoxyphenylacetate has good solubility in organic solvents, such as ethanol, ether, etc. Due to the principle of similarity and miscibility, its molecular structure is similar to that of organic solvent molecules, so it can be miscible with each other. However, in water, its solubility is very small, because its molecular polarity is quite different from that of water molecules, it is difficult to form effective interactions with water molecules.
In terms of chemical properties, the ester group of di- (triethyl) -4-p-methoxyphenylacetate is an active functional group. Under basic conditions, hydrolysis is prone to occur, and the ester group is broken to form corresponding carboxylic salts and alcohols. In acidic environments, although the hydrolysis reaction rate is slightly slower, it can be carried out gradually. And because of the presence of benzene rings, typical reactions of aromatic hydrocarbons can occur, such as halogenation reactions, nitrification reactions, etc. The hydrogen atoms on the benzene ring can be replaced to form various derivatives. This is a common reaction path in organic synthesis, whereby many valuable compounds can be prepared.

Today, there is di- (triethyl) -4-p-hydroxybenzoate ethyl ester, what is the market price?
Taste the business affairs, the price varies with time, land, quality and quantity, and it is difficult to determine the number. This di- (triethyl) -4-p-hydroxybenzoate ethyl ester, at the market price, if its quality and purity are wide, and the supply and demand are peaceful at times, its price may be stable in a certain area.
If the raw materials are abundant and the supply exceeds the demand, the price will drop. On the contrary, the raw materials are rare, and those who want them will increase the price. And the distance of the place is also related to the freight. In remote places, the price may be high.
However, if you want to know the price, you should consult the pharmacy, chemical manufacturer, or the market where you trade, and the price list, before you can get the actual price. Although it is difficult to give the exact price, it is probably in the market. Due to the difference in quality and batch, the price ranges from a few gold to tens of gold per unit, or there are special reasons for the price difference. This estimate is not enough to be accurate.

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First, it is necessary to place it in a cool and dry place to avoid direct sunlight. The intensity of sunlight can cause its properties to mutate and its medicinal power to be reduced. Because of 2 - (triethyl) - 4 - square light ethyl carboxylate, sex or fear of light and heat, exposed to the sun, fear chemical changes and lose its original efficacy.
Second, it is better to keep a dry environment and prevent moisture from invading. Moisture is dense, and it is easy to make this thing damp. Tide may cause it to dissolve, mildew, and damage its quality. If you are in a humid place in the south, you should supplement it with dry substances such as lime and charcoal to absorb the surrounding moisture and protect it from moisture.
Furthermore, the storage place should be well ventilated. Turbid gas is stagnant, the air is not smooth, and it is also harmful to 2- (triethyl) -4-square light ethyl carboxylate. The circulating air can dissipate the harmful gases that may be generated, so as to prevent it from accumulating and causing material deterioration.
In addition, it should be isolated from other substances, especially avoid being placed in a place with strong oxidants, strong acids, strong bases, etc. These substances are highly chemical, and when they are encountered, they are prone to violent reactions, or burn or explode, endangering safety. It must be stored independently with a special device and marked with a clear mark to make it easy to identify and prevent accidental touch and misuse.
The last one, the temperature is also important. Overheating can cause molecular movement and decomposition; undercooling can change the state of matter and affect its properties. Therefore, it is better to control the temperature within a suitable range, depending on its physical properties, or between 10 and 25 degrees Celsius.
Keep this number to keep 2 - (triethyl) - 4 - square light ethyl carboxylate, and keep its quality and purity.