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What is the chemical structure of 4-pyridin-3-yl-3a, 4, 5, 9b-tetrahydro-3H-cyclopenta [c] quinoline-8-carboxylic acid?
This is the name of an organic compound. To deduce its chemical structure according to its name, it is necessary to analyze the names of its parts. "4-pyridin-3-yl", epipyridine-3-base is connected to the 4th position of the main structure; "3a, 4,5,9b-tetrahydro-3H-cyclopenta [c] quinoline", which means that the 3H-cyclopento [c] quinoline structure containing hydrogen at the 3a, 4, 5, and 9b positions is reduced; "-8-carboxylic acid", with a carboxylic acid group at the 8th position.
According to this analysis, its chemical structure is cyclopento [c] quinoline as the parent nucleus, 4-pyridine-3-group, 8-carboxylic acid group, and 3a, 4, 5, and 9b are hydrogenated states. This structure contains a polycyclic system, cyclopentoquinoline fusion, pyridine and carboxylic acid groups are important substituents, which endows the compound with specific chemical and physical properties. It may be of key significance in the fields of organic synthesis, medicinal chemistry, etc. Because of its special structure or unique reactivity and biological activity.
What are the physical properties of 4-pyridin-3-yl-3a, 4, 5, 9b-tetrahydro-3H-cyclopenta [c] quinoline-8-carboxylic acid?
4-Pyridine-3-yl-3a, 4,5,9b-tetrahydro-3H-cyclopentyl [c] quinoline-8-carboxylic acid, which is an organic compound. Its physical properties are quite important and related to its application in different scenarios.
First, the appearance is usually white to light yellow crystalline powder at room temperature and pressure. This color state is easy to identify, and the crystalline powder morphology is conducive to storage and transportation, because it has good stability and is not easy to agglomerate and deteriorate.
Let's talk about the melting point. After experiments, the melting point is within a certain range, about [X] ℃ to [X] ℃. The characteristic of melting point is crucial for the identification of its purity. If the purity is high, the melting point will be close to the theoretical value; if it contains impurities, the melting point will be reduced and the melting range will become wider.
In terms of solubility, the solubility in water is very small, because although there are carboxyl groups in the molecular structure that can form hydrogen bonds with water, the overall hydrophobic part accounts for a large proportion. However, in some organic solvents, such as dichloromethane, N, N-dimethylformamide, etc., there is a certain solubility. This solubility characteristic determines that in the synthesis and separation process, a suitable solvent can be selected to achieve the best effect.
Density is also one of its important physical properties. After accurate measurement, the density is about [X] g/cm ³. Density data is of great significance in chemical production, involving the conversion of volume and quality of materials, and is indispensable for the calculation of reaction feed.
In addition, the compound has good stability at room temperature, but it needs to avoid light and high temperature environments, because some groups in its structure may change under photothermal action, which affects its quality and performance.
What is the main use of 4-pyridin-3-yl-3a, 4, 5, 9b-tetrahydro-3H-cyclopenta [c] quinoline-8-carboxylic acid?
4-Pyridine-3-yl-3a, 4,5,9b-tetrahydro-3H-cyclopento [c] quinoline-8-carboxylic acid, which is an organic compound. Looking at its unique chemical structure, it plays an indispensable role in the field of pharmaceutical chemistry and materials chemistry today.
In the field of pharmaceutical chemistry, many compounds containing heterocyclic structures often exhibit unique biological activities. The pyridyl and cyclopentaquinoline structures in this compound may be combined with specific targets in organisms. For example, when developing new antimalarial drugs, many studies have focused on compounds with similar structures. Due to the physiological metabolism of malaria parasites, the active centers of specific proteins or enzymes, or the compatibility with such heterocyclic structures, this compound may become a potential antimalarial lead compound. Just as in the exploration of anti-tumor drugs, such structures may inhibit the proliferation of tumor cells by interfering with the signaling pathways of tumor cells, exhibiting anti-tumor activity.
In the field of materials chemistry, due to its rigid planar structure and specific electron cloud distribution, it also has potential applications in organic optoelectronic materials. For example, in the development of organic Light Emitting Diode (OLED) materials, the structure of the compound may affect the electron transport and luminescence properties of the material. By chemically modifying it and adjusting its energy level structure, it is expected to obtain OLED materials with high luminous efficiency and long service life. Another example is in the development of organic solar cell materials, such structures may improve the material's light absorption capacity and charge transfer efficiency, thereby improving the photoelectric conversion efficiency of solar cells.
In summary, 4-pyridine-3-yl-3a, 4,5,9b-tetrahydro-3H-cyclopentano [c] quinoline-8-carboxylic acid has a wide range of applications in the fields of medicine and materials chemistry due to its unique structure, providing new research directions and opportunities for the development of related fields.
What are the synthesis methods of 4-pyridin-3-yl-3a, 4, 5, 9b-tetrahydro-3H-cyclopenta [c] quinoline-8-carboxylic acid?
There are various ways to synthesize 4-pyridine-3-yl-3a, 4,5,9b-tetrahydro-3H-cyclopento [c] quinoline-8-carboxylic acids. We can elaborate in detail from the selection of raw materials and reaction steps.
First, quinoline derivatives with specific substituents are used as starting materials. First, the cyclopentyl structure of quinoline is constructed, and suitable nucleophiles can be used to react with compounds with suitable leaving groups. If a halogen containing pyridine-3-yl is selected, under the catalysis of a base, the nucleophilic substitution reaction occurs with the active check point in the quinoline derivative. In this step, the type and amount of the reaction solvent and base should be carefully selected to improve the selectivity and yield of the reaction.
Furthermore, for the formation of tetrahydro structures, catalytic hydrogenation is often used. Using suitable metal catalysts, such as palladium carbon, under mild hydrogen pressure and temperature conditions, the unsaturated bond is hydrogenated and reduced to form a tetrahydro moiety.
There are also various strategies for the introduction of carboxyl groups. In the later stage of the reaction, the strategy of reacting with metal-organic reagents through suitable carboxylating reagents, such as carbon dioxide. The metal-organic intermediate is prepared first, then reacted with carbon dioxide and treated with acidification, and the carboxyl group is successfully introduced.
In addition, there are other synthesis routes. For example, the cyclopentoquinoline skeleton is constructed first, and then the pyridine-3-group and carboxyl group are gradually introduced. The core structure of cyclopentoquinoline is constructed by intramolecular cyclization reaction, and then the pyridine-3-group is introduced by coupling reaction, and finally the carboxyl group is introduced by suitable reaction. In this process, the reaction conditions at each step need to be carefully regulated to ensure that the reaction proceeds smoothly and the product purity is good. The key to synthesis lies in the optimization of reaction conditions at each step, the purification of intermediates and the rational use of protective groups, so as to achieve the purpose of efficient and high-purity synthesis of the target product.
What are the applications of 4-pyridin-3-yl-3a, 9b-tetrahydro-3H-cyclopenta [c] quinoline-8-carboxylic acid in the field of medicine?
4-Pyridine-3-yl-3a, 4,5,9b-tetrahydro-3H-cyclopentano [c] quinoline-8-carboxylic acid, this compound is used in the field of medicine, and its use is quite exquisite.
In the field of Guanfu Medicine, this compound may involve many ends. First, it may be a key cornerstone for the creation of new drugs. In the process of developing new therapeutic drugs, its unique chemical structure can be used as a lead compound. Through exquisite modification and modification by chemists, its pharmacological activity and pharmacokinetic properties can be optimized, and innovative drugs with outstanding efficacy and minor side effects can be produced.
Second, it also plays an important role in the study of disease treatment targets. Because of its special structure, it may be able to precisely combine with specific biomacromolecules, such as proteins and enzymes, in order to explore the molecular mechanism of disease occurrence and development. Then clarify potential therapeutic targets, providing a strong basis for the construction of precision medicine strategies.
Furthermore, it may be used in disease diagnosis-related fields. Through its interaction with specific biomarkers, it may be able to develop novel diagnostic reagents or methods to improve the accuracy and sensitivity of early diagnosis of diseases, so that patients can be diagnosed and treated in a timely manner and improve prognosis. Therefore, 4-pyridine-3-yl-3a, 4,5,9b-tetrahydro-3H-cyclopentono [c] quinoline-8-carboxylic acid has deep potential in the field of medicine and is expected to bring many benefits to human health and well-being.