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What are the physical properties of 4-OXO-1, 4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID?
4-OX0-1,4-dihydroquinoline-3-carboxylic acid is an organic compound or the like. Looking at its shape, under normal conditions, it may be crystalline, white or nearly white in color, and upon closer inspection, its crystal structure is regular and orderly, and the crystal surface is smooth and flat, which is quite beautiful.
Regarding its melting point, the melting point is about a specific temperature range, but the exact value may be slightly different due to differences in measurement methods and environments. Generally speaking, it needs to be at a higher temperature to see that it gradually melts from a solid state to a liquid state, which is caused by intermolecular forces. As for the boiling point, it also needs to be quite hot to enable the molecules to break free from the liquid phase and rise into the gas phase.
In terms of solubility, in water, its solubility is limited, and it is difficult to dissolve because of the characteristics of its molecular structure. However, in organic solvents such as alcohols and ethers, their solubility is different. In alcohols, because alcohol molecules and carboxylic acid molecules can form specific intermolecular forces, such as hydrogen bonds, etc., there is a certain solubility; in ether solvents, depending on the structural difference of ethers, there are also different degrees of dissolution.
Its density is different from that of water, and the specific value is related to the degree of molecular accumulation. And this material has a certain stability. Under the conventional environment, temperature and humidity, its chemical structure can be maintained relatively stable, and it is not easy to spontaneously produce chemical changes. When specific chemical reagents and conditions change, such as strong acid, strong alkali environment, or high temperature, light, etc., its structure may change, triggering various chemical reactions and exhibiting different chemical properties.
4-OXO-1, what are the chemical properties of 4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID
4 - OXO - 1,4 - DIHYDROQUINOLINE - 3 - CARBOXYLIC ACID, Chinese name or 4 - oxo - 1,4 - dihydroquinoline - 3 - carboxylic acid. The chemical properties of this substance are unique, allow me to describe it for you.
Looking at its structure, it contains a quinoline parent nucleus, and the 1,4 positions have special changes, and the 4 positions are oxo, this oxo structure makes it have a certain carbonyl nature. Carbonyl, with high chemical activity, can participate in many reactions. For example, nucleophilic addition reaction, because its carbonyl carbon is partially positively charged, it is easy to be attacked by nucleophiles. If the nucleophilic reagent is an alcohol, or can form a semi-acetal or acetal structure, it can be used as a method to protect the carbonyl group in organic synthesis; if the nucleophilic reagent is an amine, it may form imine compounds. Such reactions are often used to construct complex structures such as nitrogen-containing heterocycles.
In addition, the carboxyl group at the 3 position is also a key activity check point. The carboxyl group is acidic, and when a suitable base exists, it can undergo acid-base neutralization reaction to generate corresponding carboxylate. In some organic synthesis or drug preparation, the solubility of this salt may be different from that of orthocarboxylic acid, which can affect the separation and application of the product. And the carboxyl group can participate in the esterification reaction and form an ester bond with the alcohol under acid catalysis. Ester compounds are widely used in the fields of fragrance and drug sustained release. Through this reaction, the compound can be structurally modified and endowed with new functions.
In addition, the unsaturated conjugate system it contains endows the compound with certain photophysical properties. Or it can absorb light of specific wavelengths and undergo electron transitions. This property may have potential applications in the field of photochemistry, such as photochromic materials.
Because of the conjugate structure in its molecules, the electron cloud distribution is relatively off-domain, and the stability is also affected. Under certain conditions, reactions such as cyclization and rearrangement may occur, providing various possible paths for organic synthesis, which can prepare compounds with more complex structures and be used in many fields such as medicine and materials.
4-OXO-1, what is the main use of 4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID?
4 - OXO - 1,4 - DIHYDROQUINOLINE - 3 - CARBOXYLIC ACID, Chinese name 4 - oxo - 1,4 - di- quinoline - 3 - carboxylic acid. This substance is essential for a wide range of domains.
In the field of research, it can be used as a medium. Many bioactive compounds, especially those with antibacterial, anti-inflammatory, anti-cancer and other effects, are synthesized. In the synthesis of an antibacterial agent, for example, 4-oxo-1, 4-diquinoline-3-carboxylic acid can be specific and reversed, and other functional phases can be improved. It can inhibit or inhibit specific pathogens and provide a powerful weapon for prevention and control.
In the field of materials science, it also has extraordinary performance. Due to its unique characteristics, it can be used for the development of polymer materials. Polymerization and copolymerization, other copolymerization, and special physical properties of materials, such as improving the qualitative, mechanical or optical properties of materials. For example, in a new type of photochemical material, the introduction of 4-oxo-1,4-diquinoline-3-carboxylic acid makes the material exhibit special absorption and emission characteristics in specific waves, expanding the application of the material in the optical field, such as optical sensors, optical diodes, etc.
In addition, in the basic field of chemical research, its synthesis provides an important research image. By exploring its chemical properties, such as nuclear substitution, addition, etc., the chemical industry has expanded its synthesis methods, developed new methods of reflection, and promoted the development of chemical science and the synthesis of more new compounds. Therefore, 4-oxo-1,4-diquinoline-3-carboxylic acids play an indispensable role in the field of polymorphism, and their application prospects are promising.
What are the synthesis methods of 4-OXO-1, 4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID
4 - OXO - 1,4 - DIHYDROQUINOLINE - 3 - CARBOXYLIC ACID is 4 - oxo - 1,4 - dihydroquinoline - 3 - carboxylic acid. There are many synthesis methods, and the common ones are as follows:
One is to use anthranilic acid and ethyl acetoacetate as starting materials. In a suitable reaction vessel, the two are condensed at a specific temperature and under the action of a catalyst. In this process, the amino group of anthranilic acid interacts with the carbonyl group of ethyl acetoacetate to gradually build a quinoline ring system. After the reaction is completed, the target product can be obtained by separation and purification methods such as extraction and column chromatography. The raw materials for this route are easy to obtain, and the reaction conditions are relatively mild. However, the reaction steps may be slightly complicated, and the reaction process needs to be carefully controlled to improve the purity and yield of the product.
The second is to use aniline and maleic anhydride as starting materials. The two first undergo a condensation reaction to form an intermediate product. Then under specific reagents and reaction conditions, the intermediate product is cyclized, and then 4-oxo-1,4-dihydroquinoline-3-carboxylic acid is formed. The reaction route of this method is relatively simple, but maleic anhydride is active. During the reaction, attention should be paid to the control of its dosage and reaction conditions to prevent side reactions and ensure the formation of the target product.
In addition, 4-oxo-1,4-dihydroquinoline-3-carboxylic acid is also synthesized from quinoline through a series of reactions such as oxidation and carboxylation. Although the raw material of this path is single, the oxidation and carboxylation reaction conditions are harsh, and the reaction equipment and operation requirements are quite high, and the regulation of reaction selectivity is also quite difficult. Careful consideration is required in practical application.
Each synthesis method has its own advantages and disadvantages. In the actual synthesis, many factors such as raw material cost, reaction conditions, equipment requirements, product purity and yield should be comprehensively considered, and the most suitable synthesis path should be selected to achieve efficient and economical synthesis of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid.
4-OXO-1, 4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID What are the precautions in storage and transportation
4 - OXO - 1,4 - DIHYDROQUINOLINE - 3 - CARBOXYLIC ACID, that is, 4 - oxo - 1,4 - dihydroquinoline - 3 - carboxylic acid, there are a number of urgent matters that need to be paid attention to during storage and transportation.
First of all, on storage. Due to its chemical properties, it is necessary to find a cool, dry and well-ventilated place to place. If the storage environment temperature is too high, it may cause its chemical structure to change and cause it to deteriorate. For example, if the temperature is too high, the chemical bonds in the molecule may break or rearrange, causing the original chemical activity and characteristics to be lost. If the ambient humidity is too high, the acid is easy to absorb moisture, or agglomerate, which not only affects the convenience of use, but also accelerates its reaction with surrounding substances. Therefore, in the warehouse, the control of temperature and humidity is the key, the temperature should be maintained at a specific low temperature range, and the humidity should also be kept at a certain low value.
Furthermore, this material may have a certain chemical sensitivity, and should be avoided from mixing with oxidants, reducing agents, alkalis and other substances. Oxidants can cause oxidation reactions and change their chemical structure; reducing agents can also cause reduction reactions, which can change their properties; alkalis contact with it, or reactions such as acid-base neutralization, can damage its quality. Therefore, substances of different chemical properties must be stored in zones and clearly marked.
As for transportation, the packaging must be solid and reliable. Use suitable packaging materials, such as containers with good sealing properties, to prevent leakage during transportation. Road bumps, vibrations or damage to the packaging, so the packaging design needs to be able to cushion external shocks. When loading and unloading, you should also be careful, handle it lightly, and do not treat it rudely to avoid damage to the packaging. At the same time, the environment of the transportation vehicle also needs to be considered to keep the vehicle dry and free of other chemical pollution. Transport personnel should also be familiar with the characteristics of this object and emergency treatment methods. In case of leakage and other accidents, they can be disposed of quickly and properly to reduce harm.