4-oxo-1,4-dihydroquinoline-3-carbaldehyde

4-Oxo-1,4-dihydroquinoline-3-carbalaldehyde, Chinese name 4-oxo-1,4-dihydroquinoline-3-formaldehyde, is widely used. In the field of medicinal chemistry, it is often used as a key intermediate to help synthesize many bioactive compounds. For example, in the creation process of some new antibacterial drugs, the specific chemical structure it participates in building plays a crucial role in enhancing the binding force between the drug and the bacterial target, thereby enhancing the antibacterial effect. In the field of organic synthesis, with its unique structure, it can be cleverly spliced with other organic molecules through a series of chemical reactions, such as the condensation reaction of aldehyde groups, nucleophilic addition reaction, etc., to construct complex and diverse organic compounds, providing an important raw material choice for organic synthesis chemists to expand their compound library. At the same time, in the field of materials science, some conjugated organic materials synthesized with it as a starting material exhibit unique optical and electrical properties, which are expected to be applied to the research and development of new photoelectric materials, such as organic Light Emitting Diode (OLED), solar cells, etc., to contribute to the optimization and innovation of material properties.

4-Oxo-1,4-dihydroquinoline-3-carbalaldehyde is an important compound in the field of organic synthesis. There are many synthesis methods, each with thousands of years, and the following is described in detail by you.
First, the method of using quinoline as the starting material. First modify the specific position of quinoline, introduce a suitable substituent, and then oxidize to construct a carbonyl group at the 4 position, and then introduce an aldehyde group at the 3 position through specific reaction conditions. In this process, the oxidation step is very critical, and the oxidizer and reaction conditions need to be carefully selected to ensure that the reaction occurs precisely at the 4 position without affecting other parts. Commonly used oxidants, such as certain high-valent metal salts, can achieve this conversion under appropriate solvents and temperatures.
Second, the synthesis path using aniline derivatives and β-ketoate as starting materials. The two first undergo a condensation reaction to form a quinoline ring precursor structure. This reaction requires a suitable catalyst to facilitate its smooth progress. Subsequently, the precursor structure is oxidized and functional group transformed to generate carbonyl at 4 positions and aldehyde at 3 positions. The advantage of this route is that the starting material is relatively common, easy to obtain, and the condensation reaction conditions are relatively mild, but the subsequent oxidation and functional group conversion steps still need to be carefully regulated.
Third, the method of transition metal catalysis is used. The halogenated aromatics and enamines containing suitable substituents are used as raw materials, and the quinoline ring is constructed by cyclization under the action of transition metal catalysts. After that, the target product is obtained by selective oxidation and aldehyde reaction. This method relies on the high-efficiency catalytic performance of transition metal catalysts, which can achieve more complex structure construction, but the choice and dosage of catalysts have a great impact on the yield and selectivity of the reaction. < Br >
Synthesis of 4 - oxo - 1, 4 - dihydroquinoline - 3 - carbalaldehyde method, each has its advantages and disadvantages, the practical application, according to the specific experimental conditions, the availability of raw materials and the purity requirements of the target product, etc., carefully choose.

4-Oxo-1,4-dihydroquinoline-3-carbalaldehyde is an organic compound with specific physical properties. In terms of its color state, it is mostly solid at room temperature and pressure, but it varies depending on the purity and crystallization status, or it is white to light yellow crystalline powder, just like the ancient books say that the morphology of the substance is changeable, and it varies depending on the environment and preparation process.
The melting point is very critical for the identification of this compound. After many experiments, its melting point is about a certain range (the specific value varies slightly due to experimental conditions), just like the ancient alchemists' accurate grasp of the characteristics of medicinal pills. This melting point characteristic can help to distinguish the substance and determine the purity.
Solubility is also an important property, and the solubility of this compound in organic solvents varies. In common organic solvents such as ethanol and dichloromethane, it has a certain solubility, just like ancient pharmaceuticals are integrated into different medicinal introductions; but it has poor solubility in water. Due to the limited hydrophilic groups in the molecular structure and the dominance of hydrophobicity, it is difficult to dissolve in water. This property is similar to that of many organic compounds, and it needs to be carefully considered when separating, purifying and selecting the reaction medium.
In addition, the compound has a certain volatility. Under specific temperatures and environments, it will evaporate slowly and emit a special smell, just like ancient fragrances emit a unique smell. This volatility should also be paid attention to when storing and using, and should be properly preserved to prevent material loss and impact on the environment.

4-Oxo-1,4-dihydroquinoline-3-carbalaldehyde is an organic compound with many unique chemical properties.
This substance contains an aldehyde group (-CHO) and a 4-oxo-1,4-dihydroquinoline structure. The aldehyde group is active and can undergo a variety of reactions. First, it can participate in the oxidation reaction. Under the action of a suitable oxidant, the aldehyde group can be oxidized to a carboxyl group (-COOH) to obtain the corresponding carboxylic acid derivatives. This process is often an important step in organic synthesis, whereby carboxyl functional groups can be introduced to prepare compounds with different properties. < Br >
Second, the aldehyde group can be condensed with compounds containing active hydrogen, such as alcohols. When reacted with alcohols, acetals can be formed. This reaction is often used in organic synthesis to protect the aldehyde group from being affected in subsequent reactions. The aldehyde group is restored by a specific step of dissociation protection at a specific stage.
Furthermore, due to the conjugate structure in the molecule, the 4-oxo-1,4-dihydroquinoline part gives the compound a certain stability and special electron cloud distribution. The conjugate system affects its spectral properties, and there are specific absorption peaks in the ultraviolet-visible spectrum, which can be used for qualitative and quantitative analysis.
At the same time, such structures also make the molecule have a certain acidity and alkalinity. Although it is not a typical strong acid or base, it can exhibit weak acidity or alkalinity under specific conditions due to the influence of conjugation and functional groups. It can participate in some acid-base related reactions, and undergo proton transfer with acids or bases, which in turn affects its reactivity and product structure. In short, 4-oxo-1,4-dihydroquinoline-3-carbalaldehyde has rich chemical properties and has important research and application value in organic synthesis, pharmaceutical chemistry and other fields.

Today there are 4-oxo-1,4-dihydroquinoline-3-carbalaldehyde, and I don't know for sure what the price is in the market. However, although "Tiangong Kaiwu" is an ancient strange book, it contains many crafts and agricultural and mulberry things, and does not involve the price of this thing.
This 4-oxo-1,4-dihydroquinoline-3-carbalaldehyde, or a new chemical made in modern times, its price may change for a variety of reasons. If the source of its raw materials, the rarity or ease of availability of raw materials is related to the cost, and the cost will affect its price. Another example is the difficulty of preparation. If the process is complicated and time-consuming, the price will not be cheap; if the preparation is easy and requires less manpower and material resources, the price may be slightly lower.
Furthermore, the supply and demand of the city is also the main reason. If there are many people who want it, the supply will be few, and the price will rise; if the supply exceeds the demand, the price will drop. And its use also has an impact. If it is indispensable in urgent fields such as medicine and chemical industry, its price may be high. Sadly, it is difficult to find clues about its price in the ancient book "Tiangong Kaiwu". If you want to know the exact price in the market, or you should consult today's chemical merchants, industry experts, or check the information platform of chemical product trading, you can get it.