4-Isoquinolinecarboxaldehyde

4-Isoquinoline formaldehyde is a class of organic compounds. It has unique chemical properties and has important uses in many fields.
From a structural point of view, this molecule contains an isoquinoline ring and an aldehyde group. The isoquinoline ring is aromatic, giving the compound a certain stability and a special electron cloud distribution. The presence of aldehyde groups adds many changes to its chemical reactivity.
In terms of chemical properties, aldehyde groups are extremely active. The classic oxidation reaction can occur. In case of strong oxidants, it can be oxidized to 4-isoquinolinecarboxylic acid; in case of weak oxidants, such as Torun reagent or Feilin reagent, silver mirror reaction or brick red precipitation can occur. This property is often used as a qualitative test for aldehyde groups.
It can also undergo reduction reactions. Under the action of suitable reducing agents, aldehyde groups can be reduced to 4-isoquinoline methanol. In addition, the carbon-oxygen double bonds of aldehyde groups can undergo nucleophilic addition reactions, such as reactions with alcohols, which can generate acetals; when reacted with Grignard reagents, new carbon-carbon bonds can be formed, which is an important means for building complex structures in organic synthesis. < Br >
The aromatic properties of the isoquinoline ring enable 4-isoquinoline formaldehyde to participate in electrophilic substitution reactions. Although the reactivity is different from that of the benzene ring, substitutes can be introduced at specific positions of the isoquinoline ring under appropriate conditions to expand the types of derivatives.
Because of its unique structure and properties, 4-isoquinoline formaldehyde is often used as a key intermediate in the field of medicinal chemistry for the synthesis of biologically active drug molecules; in materials science, functional materials with special properties can be prepared through specific reactions.

There are several common synthesis methods for 4-isoquinoline formaldehyde. One is to use isoquinoline as the starting material and obtain it by oxidation reaction. First, take an appropriate amount of isoquinoline, place it in a reactor, add a specific oxidant, such as a mixed system of manganese dioxide and sulfuric acid, heat and stir to oxidize isoquinoline. Under specific conditions, its side chain is oxidized to an aldehyde group, and then 4-isoquinoline formaldehyde is obtained.
Furthermore, it can be prepared by the reaction of halogenated isoquinoline with metal salts. The isoquinoline is first halogenated to obtain halogenated isoquinoline, and then reacted with metal cyanides, such as cuprous cyanide, in an appropriate solvent to form nitrile intermediates, and then hydrolyzed to convert the nitrile group into an aldehyde group. This is also one way to prepare 4-isoquinoline formaldehyde.
There are also benzene ring derivatives containing aldehyde groups and nitrogen-containing heterocyclic compounds through condensation reaction. The benzene derivative with aldehyde groups and suitable nitrogen-containing five or six-membered heterocyclic rings are condensed under the catalysis of acids or bases to construct isoquinoline rings, while retaining the aldehyde groups, and finally 4-isoquinoline formaldehyde is obtained.
All synthetic methods have their own advantages and disadvantages, and it is necessary to consider factors such as raw material cost, reaction conditions, yield and purity according to actual needs, and choose the appropriate one.

4-Isoquinoline formaldehyde is useful in many fields. In the field of medicine, it is a key traditional Chinese medicine. It can be used as a starting material for the synthesis of a variety of drugs. With its unique chemical structure, it can participate in the construction of molecules with specific pharmacological activities. For example, in the creation of anti-tumor drugs, or by its interaction with specific targets of tumor cells, new anti-cancer drugs with high selectivity and low toxicity and side effects can be developed.
In the field of material chemistry, 4-isoquinoline formaldehyde also exhibits its properties. Using it as a raw material and through specific reactions, materials with specific optical and electrical properties can be prepared. For example, it can be used in organic Light Emitting Diode (OLED), or it can improve its luminous efficiency and stability, and improve the quality of display technology.
In the path of scientific research and exploration, it is a commonly used reagent in organic synthesis chemistry. Chemists can take advantage of its aldehyde activity to react with various nucleophiles to expand the structural diversity of molecules and open up a path for the synthesis of new compounds. In the field of catalysis, the structure of 4-isoquinoline formaldehyde can be modified to prepare a catalyst with high catalytic activity to accelerate the chemical reaction process and improve the reaction yield.
Furthermore, in the dye industry, 4-isoquinoline formaldehyde may provide the possibility for the synthesis of new dyes. By ingeniously designing its structure, dyes with bright color and excellent fastness can be obtained, which are used in textile, printing and dyeing industries to meet people's diverse needs for color. In conclusion, 4-isoquinoline formaldehyde has great application potential and value in many aspects such as medicine, materials, scientific research, dyes, etc.

4-Isoquinoline formaldehyde, the color is light yellow to white, and it is a crystalline powder at room temperature. Its melting point is quite important, between 133-137 ° C. This property is very useful for identification and purification.
Solubility is also a key physical property. It has good solubility in organic solvents such as dichloromethane, chloroform, and ethanol, but it has little solubility in water. This difference in solubility facilitates separation and reaction operations. For example, in organic synthesis reactions, suitable solvents can be selected according to this characteristic to promote the smooth progress of the reaction.
4-Isoquinoline formaldehyde has a low vapor pressure, indicating that its tendency to volatilize at room temperature is small and its chemical properties are relatively stable. However, under heating or under specific conditions, it can exhibit the typical chemical activity of aldehyde groups.
Although its density does not have an exact commonly stated value, as an organic compound, the density is similar to that of common aromatic alarms. Although this physical property is not a key consideration, it may have some impact in specific application scenarios, such as those involving density-dependent separation or mixing processes.
In addition, 4-isoquinoline formaldehyde has a weak odor and a special aromatic aroma. This sensory property may need to be considered in specific product applications, such as fragrance blending or in environments with strict odor requirements.

The price of 4-isoquinoline formaldehyde in the market is difficult to break. The price of this compound often changes due to many factors.
The simplicity of its production is the key to the price. If the production requires complex methods and thinner materials, the price will be high. Due to the difficult reactions in the preparation or the rare reagents, the cost will increase greatly, and the price will also rise.
Furthermore, the supply and demand of the market also affect the price. If there are many people who want it, but the supply is limited, the price will rise; if the supply exceeds the demand, the price will drop. Changes in the industry and the expansion of new uses can make the supply and demand easier.
The difference in quality also makes the price different. < Br >
In addition, the purchase quantity also has an impact. Buyers who buy in bulk often get the best price due to large quantities; if they buy in small quantities, the price may be higher.
And different sources of goods, the price varies. Well-known record labels, with excellent management and strict inspection, the price may be slightly higher; while products from small factories or new enterprises, the price may be cheaper.
The price of 4-isoquinoline formaldehyde in the market varies from a few yuan to hundreds of yuan per gram, or even higher, depending on the above reasons. If you want to know the exact price, you should consult the chemical supplier or check the latest price information of the chemical product trading platform.