4-Hydroxyquinoline,(4-Quinolinol)

4-Hydroxyquinoline, (4-quinolinol), has a wide range of uses. It can be used as a raw material for the synthesis of drugs in the field of medicine. Because of its unique structure and biological activity, it can contribute to the creation of anti-malarial, antibacterial and anti-tumor drugs. If physicians in the past sought a cure for diseases, today's scientists borrow 4-hydroxyquinoline to explore the way to create new drugs and solve the difficulties of diseases.
In the field of materials, it can also be used. It can be used to prepare optoelectronic materials. Due to its special molecular configuration, the materials can have unique optical and electrical properties. Just like the ancient craftsmen who chose good materials to make utensils, today they use 4-hydroxyquinoline as the basis to make new photoelectric materials, which are used in display screens, sensors, etc., to help the progress of science and technology.
In organic synthesis, 4-hydroxyquinoline is a key intermediate, which can be derived from a variety of organic compounds. Like the cornerstone of building a house, organic synthesis relies on this to expand the molecular structure and enrich the variety of compounds. It is useful in fine chemicals, materials science, etc., and the industry is prosperous, promoting the progress of chemical technology.

4-Hydroxyquinoline, also known as 4-quinolinol, is one of the unique characteristics of organic compounds. Its physical properties are crucial and have a profound impact on its application in many fields.
The first to bear the brunt, looking at its appearance, 4-hydroxyquinoline is usually a light yellow to brown crystalline powder. This morphological feature is easy to identify and process, and in practice, it can be quickly identified by virtue of its unique appearance.
As for the melting point, the melting point of 4-hydroxyquinoline is between 267-270 ° C. The melting point is an important consideration in the purification, identification and reaction study of substances under specific temperature conditions. The high melting point indicates that the intermolecular force is strong and the structure is relatively stable.
Furthermore, solubility is also one of the key properties. 4-hydroxyquinoline is slightly soluble in water, but soluble in organic solvents such as ethanol, ether, chloroform, etc. This difference in solubility makes it possible to reasonably select solvents according to their characteristics during chemical reactions, separation and purification of different solvent systems. Good solubility in organic solvents facilitates many organic synthesis reactions, and can be used as reactants or intermediates to play an important role in the field of organic synthesis.
In addition, 4-hydroxyquinoline has certain sublimation properties. Although the sublimation conditions are more demanding, this property can be used in specific separation and purification processes to obtain high-purity products.
Its physical properties such as density and stability also affect its practical application. The appropriate density determines its distribution and behavior in different media, while the relatively stable chemical structure makes 4-hydroxyquinoline maintain its own structure and properties at room temperature and pressure, which is conducive to storage and transportation.
The physical properties of 4-hydroxyquinoline are diverse and unique. These properties lay the foundation for its wide application in medicine, chemical industry, materials and many other fields. In scientific research and industrial production, these properties need to be fully considered and rationally utilized.

The chemical properties of 4-hydroxyquinoline (4-quinoline alcohol) are still stable under normal temperature and pressure. However, under specific conditions, it also exhibits different reaction characteristics.
Looking at its structure, it contains hydroxyl groups and quinoline rings, which give it unique chemical activity. The presence of hydroxyl groups allows the molecule to participate in many nucleophilic substitution reactions. In the case of strong electrophilic reagents, the lone pair electrons on the hydroxyl oxygen atom can attack the electrophilic reagents, thereby triggering substitution and generating other derivatives.
The conjugated system of the quinoline ring endows the molecule with certain stability, but also makes the electron cloud density distribution on the ring uneven. Under appropriate conditions, the electrophilic substitution reaction can occur, and the position with high electron cloud density on the ring is the reaction check point.
As for its stability, it is difficult to maintain the stability of 4-hydroxyquinoline when exposed to high temperature, open flame or strong oxidant. High temperature can cause the vibration of the chemical bond in the molecule to intensify, and to a certain extent, the chemical bond will break and initiate a decomposition reaction. Strong oxidants can seize its electrons, causing oxidation reactions to occur and changing the molecular structure.
And 4-hydroxyquinoline behaves differently in acid-base environments. In acidic media, hydroxyl groups can be protonated to enhance their nucleophilicity; in alkaline environments, hydroxyl hydrogen can be captured to form corresponding salts, which in turn affects its chemical activity and stability.
In summary, the chemical properties of 4-hydroxyquinoline are relatively stable under conventional conditions, but in special conditions such as high temperature, strong oxidation, and specific acid-base environments, its stability will be challenged, showing a variety of chemical reactivity.

The synthesis method of 4-hydroxyquinoline (4-quinolinol) has been known for a long time. In the past, he was a wise man and studied in the field of chemistry for many years, and gradually obtained many methods.
First, quinoline is used as the starting material and can be obtained by oxidation. This method requires the selection of a suitable oxidant, such as potassium permanganate. Under specific reaction conditions, quinoline is oxidized, and its specific position is affected by an oxidant, and the hydroxyl group replaces the corresponding hydrogen atom to form 4-hydroxyquinoline. However, this process requires fine control of the reaction temperature, time and amount of oxidant. If there is a slight difference, the product will be impure or the yield will be poor.
Second, with the help of a variant of the Skraup synthesis method. The Skraup synthesis method is a classic for the synthesis of quinoline compounds. On this basis, the reactants and reaction conditions are skillfully adjusted. The aniline derivative of a specific substituent and a suitable unsaturated aldehyde or ketone are selected. Under the catalysis of strong acids such as sulfuric acid, the quinoline derivative is first synthesized by a series of reactions such as condensation and cyclization. After subsequent modification, the hydroxyl group is introduced at the 4 position to obtain 4-hydroxyquinoline. Although the steps in this way are slightly complicated, it can be flexibly adjusted to obtain products with different substitution modes, which is quite advantageous.
Third, the coupling reaction catalyzed by transition metals is used. Modern chemistry, transition metal catalysis is widely used. A suitable halogenated quinoline derivative is selected, and hydroxyl source reagents, such as phenolic derivatives, are used to realize the coupling of carbon-oxygen bonds under the action of transition metal catalysts and ligands such as palladium and copper, and the hydroxyl group is introduced into the quinoline position 4. This method is relatively mild in conditions, has good selectivity, and is more environmentally friendly, and has been favored in recent years. However, the catalyst price is expensive, and cost control is the key to be considered.

4-Hydroxyquinoline (4-quinoline alcohol) is in the market, and its price range is difficult to determine. The price of this product often changes for many reasons, such as its quality, the amount of purchase, the supply and demand of the city, and even the place where it is produced and the merchants who sell it.
If its quality is excellent, it is a high-purity product, suitable for fine experiments or high-end manufacturing, its price will be high. And if the quality is slightly inferior, the price may be slightly reduced. And if the purchase quantity is quite large, the merchant may give a discount to promote the sale, and the price will also drop. The supply and demand situation of the city is also the main reason. If there are many people who ask for it, but the supply is small, the price will rise; on the contrary, if the supply exceeds the demand, the price will fall.
Furthermore, the origin is different, and the price is also different. From the place of high production, the craftsmanship is skilled, the cost may be high, and the price follows. And the business's business strategy is different, and its pricing is also different. Or there are small profits but quick turnover, the price is slightly close to the people; or the quality is good and the profit is thick, but the price is high.
It is difficult to specify the range of its price now. Roughly speaking, its price may range from tens of gold per gram to hundreds of gold per gram. In order to obtain an accurate price, you must consult the supplier of chemical materials in person, or visit a company that specializes in such reagents, and observe the situation in detail before you can know the exact price.