4-HYDROXYQUINOLINE-3-CARBOXYLICACID

4-Hydroxyquinoline-3-carboxylic acid, an organic compound, has multiple unique chemical properties and is widely used in many fields.
In terms of its physical properties, it may be a solid under normal conditions, and the specific properties are affected by factors such as crystallization conditions. Parameters such as melting point and boiling point are of great significance for the identification and purification of this substance, but the exact values vary depending on the precise determination conditions.
Chemically, carboxylic groups are acidic and can neutralize with bases to form corresponding carboxylate salts. For example, by reacting with sodium hydroxide, 4-hydroxyquinoline-3-carboxylate sodium and water are formed. This acidic property can be used to construct compounds with specific structures in organic synthesis, and can also be used to adjust the pH of the reaction system.
Hydroxyl groups are also active and easily participate in substitution reactions. Under suitable conditions, hydroxyl hydrogen atoms can be replaced by other atoms or groups, such as reacting with halogenated hydrocarbons to form ether derivatives. This substitution reaction can expand the structural diversity of compounds and lay the foundation for the creation of new functional materials or drugs.
In 4-hydroxyquinoline-3-carboxylic acids, the quinoline ring provides a unique electronic environment, endowing the molecule with a conjugated system, so that the substance has certain photophysical properties. It may absorb light of specific wavelengths and undergo electron transitions. This property may have applications in the field of fluorescent materials or photocatalysis.
Furthermore, the compound can undergo esterification reaction. Under the action of catalysts, carboxyl groups and alcohols form corresponding ester compounds. This reaction provides a way for organic synthesis to prepare ester products. The synthesized esters may have different physical and chemical properties to meet different industrial and scientific research needs.
4-hydroxyquinoline-3-carboxylic acid has received extensive attention in the fields of medicinal chemistry and materials science due to the existence of various activity check points in its structure. In drug development, its structure can be modified and optimized to obtain specific bioactive compounds; in the field of materials, its photophysical properties and reactivity may be used to prepare new optical materials or functional polymer materials.

4-Hydroxyquinoline-3-carboxylic acid, which has important applications in many fields such as medicine and chemical industry.
In the field of medicine, it can be used as a key intermediate to create a variety of drugs. Such as antibacterial drugs, the structural characteristics of 4-hydroxyquinoline-3-carboxylic acid can help it combine with specific bacterial targets, interfere with normal physiological activities of bacteria, and achieve antibacterial effect. In the development of anti-tumor drugs, it also has potential value, or can inhibit the growth and spread of tumor cells by regulating the signaling pathway of tumor cells.
In the chemical industry, it can be used as a raw material for organic synthesis. With its unique chemical properties, it participates in the synthesis of many complex organic compounds and prepares materials with special properties. For example, in the synthesis of polymer materials, the introduction of 4-hydroxyquinoline-3-carboxylic acid structural units can endow materials with unique optical and electrical properties, which can be used in optoelectronic materials.
Furthermore, in scientific research experiments, it is often used as a chemical reagent, providing strong support for the study of various chemical reaction mechanisms and the exploration of new synthesis methods. Due to its special structure and reactivity, it can trigger a variety of chemical reactions, opening up a broad space for researchers to explore the mysteries of chemistry. In short, 4-hydroxyquinoline-3-carboxylic acids play an important role in many fields and promote the development and progress of related industries.

The preparation method of 4-hydroxyquinoline-3-carboxylic acid is an important matter for chemical preparation. To prepare this substance, a common method is to use suitable starting materials and obtain it through several steps of reaction.
One method is to take a compound containing quinoline structure first, and this compound has a group that can be modified at a suitable position. Take a substance containing a quinoline ring and a halogen atom at a specific position as an example, and first react it with a nucleophilic reagent. This nucleophilic reagent needs to be able to introduce a carboxyl precursor. If potassium cyanide reacts with it, the halogen atom is replaced by a cyanide group to form a quinoline derivative containing a cyanide group. This step of the reaction needs to be carried out in a suitable solvent, such as a polar aprotic solvent, such as dimethylsulfoxide, in order to facilitate the smooth occurrence of the reaction.
Then, the generated cyanyl derivative is hydrolyzed. When hydrolyzing, an acid or base can be used as a catalyst. If catalyzed by an acid, such as a dilute solution of sulfuric acid, heated to reflux, the cyanyl group can be gradually converted into a carboxyl group to obtain a quinoline compound containing a carboxyl group.
If you want to introduce a hydroxyl group, you can follow the principle of hydroxylation reaction. For example, using a similar idea of hydroxylation of phenolic compounds, under the action of a suitable oxidant and catalyst, a hydroxyl group is introduced at a suitable position in the quinoline If a peroxide is used as an oxidizing agent and a specific metal salt is used as a catalyst, the reaction temperature and time are controlled to form the hydroxyl group at the target position, and the final product is 4-hydroxyquinoline-3-carboxylic acid.
During the preparation process, each step of the reaction requires fine control of the reaction conditions, such as temperature, reaction time, and the proportion of reactants, etc., to ensure that the reaction proceeds in the desired direction and improve the purity and yield of the product. In this way, the desired 4-hydroxyquinoline-3-carboxylic acid can be obtained.

4-Hydroxyquinoline-3-carboxylic acid, the price of this substance in the market is difficult to determine. Prices in the market often change due to various reasons, such as wide and narrow production sources, difficulty in preparation, and the number of purchases, all of which are related.
Looking at the past, if the production source is abundant, the preparation method is simple and mature, and there are few buyers, the price may be cheap. At that time, its price may be between a few yuan and tens of yuan per gram. Due to the easy availability of raw materials, stable processes, and competition from manufacturers, the price is low.
However, if the source is scarce, the preparation technique is complicated, and exquisite equipment and exquisite skills are required, and there are many buyers, the price will be high. At this time, the price per gram may reach hundreds of yuan, or even more than a thousand. Due to the scarcity, the preparation cost has increased greatly, and the demand is hot, and merchants take advantage of the trend to raise prices.
And the market fluctuates, sometimes the supply exceeds the demand, and the price drops; sometimes the supply exceeds the demand, and the price rises. In order to know the exact price, when consulting chemical material suppliers and chemical trading platforms, and carefully examining the price of recent transactions, a more accurate figure can be obtained.

4-Hydroxyquinoline-3-carboxylic acid, this is an organic compound. Regarding its safety and toxicity, although the book "Tiangong Kaiwu" does not directly mention it, it can be briefly inferred according to today's chemical knowledge and research.
The safety of this compound is first mentioned. This compound is usually more stable if it is stored in a dry, well-ventilated place under normal temperature and pressure, and protected from open flames and hot topics. However, when operating in the laboratory, because it has certain chemical activity, the operation needs to be rigorous. For example, when using clean utensils, avoid mixing them with other impurities to prevent the reaction from changing. And because some organic compounds may undergo photochemical reactions under light, it is also advisable to store them away from strong light.
As for toxicity, current studies have shown that 4-hydroxyquinoline-3-carboxylic acid has different degrees of effects on organisms. In animal experiments, if ingested in excess, it may cause digestive system disorders, such as gastrointestinal discomfort, loss of appetite, etc. At the cellular level, it may interfere with the normal metabolism and physiological functions of cells. Inhalation of its dust, or irritate the respiratory tract, causing cough, asthma and other symptoms. Skin contact may also cause allergies, redness and swelling.
In summary, although it is not detailed in Tiangong Kaiwu, according to scientific understanding, when operating and using 4-hydroxyquinoline-3-carboxylic acid, it is necessary to follow safety procedures and take protective measures to avoid possible hazards.